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Aliases for MIR4467 Gene

Subcategory (RNA class) for MIR4467 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4467 Gene

  • MicroRNA 4467 2 3
  • LRWD1 4 5
  • Leucine Rich Repeats And WD Repeat Domain Containing 1 5
  • Origin Recognition Complex-Associated Protein 4
  • ORC-Associated Protein 4
  • Centromere Protein 33 4
  • Hsa-Mir-4467 3
  • CENP-33 4
  • ORCA 4

External Ids for MIR4467 Gene

Previous GeneCards Identifiers for MIR4467 Gene

  • GC07U903186
  • GC07P102116
  • GC07P102117
  • GC07P102471

Summaries for MIR4467 Gene

Entrez Gene Summary for MIR4467 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4467 Gene

MIR4467 (MicroRNA 4467) is an RNA Gene, and is affiliated with the miRNA class.

UniProtKB/Swiss-Prot for MIR4467 Gene

  • Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4467 Gene

Genomics for MIR4467 Gene

Regulatory Elements for MIR4467 Gene


Promoters for MIR4467 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIR4467 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4467 Gene

Chromosome:
7
Start:
102,464,929 bp from pter
End:
102,473,168 bp from pter
Size:
8,240 bases
Orientation:
Plus strand

Genomic View for MIR4467 Gene

Genes around MIR4467 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4467 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4467 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4467 Gene

Proteins for MIR4467 Gene

  • Protein details for MIR4467 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UFC0-LRWD1_HUMAN
    Recommended name:
    Leucine-rich repeat and WD repeat-containing protein 1
    Protein Accession:
    Q9UFC0
    Secondary Accessions:
    • A8K4K2
    • B2R9G2
    • Q8N0T9
    • Q8WV43
    • Q96GJ2

    Protein attributes for MIR4467 Gene

    Size:
    647 amino acids
    Molecular mass:
    70861 Da
    Quaternary structure:
    • Integral component of the ORC complex. Directly interacts with CDT1, GMNN and ORC2. Interacts with ORC2 only when non-ubiquitinated; this interaction prevents LRWD1 ubiquitination and degradation. Some of these interactions are regulated in a cell-cycle dependent manner. Interaction with ORC1 occurs predominantly during G1. Association with phosphorylated ORC1 during mitosis is not efficient. Interaction with CDT1 occurs during G1 phase, as well as during mitosis with phosphorylated CDT1. Interaction with GMNN occurs from G1/S to mitosis. Interaction with ORC2 is observed throughout the cell cycle. The stoichiometry of the ORCA/ORC/CDT1/GMNN complex is 1:1:1:2. Interacts with CUL4A and DDB1; this interaction may lead to ubiquitination.
    • Integral component of the ORC complex. Directly interacts with CDT1, GMNN and ORC2. Interacts with ORC2 only when non-ubiquitinated; this interaction prevents LRWD1 ubiquitination and degradation. Some of these interactions are regulated in a cell-cycle dependent manner. Interaction with ORC1 occurs predominantly during G1. Association with phosphorylated ORC1 during mitosis is not efficient. Interaction with CDT1 occurs during G1 phase, as well as during mitosis with phosphorylated CDT1. Interaction with GMNN occurs from G1/S to mitosis. Interaction with ORC2 is observed throughout the cell cycle. The stoichiometry of the ORCA/ORC/CDT1/GMNN complex is 1:1:1:2. Interacts with CUL4A and DDB1; this interaction may lead to ubiquitination.
    • Integral component of the ORC complex. Directly interacts with CDT1, GMNN and ORC2. Interacts with ORC2 only when non-ubiquitinated; this interaction prevents LRWD1 ubiquitination and degradation. Some of these interactions are regulated in a cell-cycle dependent manner. Interaction with ORC1 occurs predominantly during G1. Association with phosphorylated ORC1 during mitosis is not efficient. Interaction with CDT1 occurs during G1 phase, as well as during mitosis with phosphorylated CDT1. Interaction with GMNN occurs from G1/S to mitosis. Interaction with ORC2 is observed throughout the cell cycle. The stoichiometry of the ORCA/ORC/CDT1/GMNN complex is 1:1:1:2. Interacts with CUL4A and DDB1; this interaction may lead to ubiquitination.

neXtProt entry for MIR4467 Gene

Post-translational modifications for MIR4467 Gene

  • Ubiquitinated; undergoes Lys-48-linked polyubiquitination leading to proteasomal degradation. Ubiquitination occurs within the WD repeats at the end of the G1 phase. Ubiquitination may be catalyzed by the CUL4-DDB1 E3 ubiquitin-protein ligase complex and other E3 ligases.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MIR4467 Gene

Domains & Families for MIR4467 Gene

Gene Families for MIR4467 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UFC0

UniProtKB/Swiss-Prot:

LRWD1_HUMAN :
  • The entire WD repeat region is required for the interaction with ORC, CDT1 and GMNN, as well as for association with chromatin and for binding to histone H3 and H4 trimethylation marks H3K9me3 and H4K20me3.
  • Belongs to the LRWD1 family.
  • Contains 4 LRR (leucine-rich) repeats.
Domain:
  • The entire WD repeat region is required for the interaction with ORC, CDT1 and GMNN, as well as for association with chromatin and for binding to histone H3 and H4 trimethylation marks H3K9me3 and H4K20me3.
Family:
  • Belongs to the LRWD1 family.
Similarity:
  • Contains 4 LRR (leucine-rich) repeats.
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with MIR4467: view

No data available for Suggested Antigen Peptide Sequences for MIR4467 Gene

Function for MIR4467 Gene

Molecular function for MIR4467 Gene

UniProtKB/Swiss-Prot Function:
Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability.

Gene Ontology (GO) - Molecular Function for MIR4467 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI --
GO:0008327 methyl-CpG binding IDA --
GO:0035064 methylated histone binding IDA --
genes like me logo Genes that share ontologies with MIR4467: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4467 Gene

Localization for MIR4467 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR4467 Gene

Nucleus. Chromosome, centromere. Chromosome, telomere. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Note=Localizes to heterochromatin during G1 phase. Restricted to centromeres or telomeres as cells progress though S phase. When cells enter mitosis, relocalizes to centromeres. Recruitment to pericentric heterochromatin largely depends on the presence of H3K9me3.

Gene Ontology (GO) - Cellular Components for MIR4467 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005664 nuclear origin of replication recognition complex IDA --
GO:0005721 pericentric heterochromatin IDA --
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with MIR4467: view

No data available for Subcellular locations from COMPARTMENTS for MIR4467 Gene

Pathways & Interactions for MIR4467 Gene

SuperPathways for MIR4467 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4467 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006270 DNA replication initiation TAS --
GO:0006325 chromatin organization IMP --
GO:0016568 chromatin modification IEA --
GO:0071169 establishment of protein localization to chromatin IDA --
genes like me logo Genes that share ontologies with MIR4467: view

No data available for Pathways by source and SIGNOR curated interactions for MIR4467 Gene

Drugs & Compounds for MIR4467 Gene

No Compound Related Data Available

Transcripts for MIR4467 Gene

mRNA/cDNA for MIR4467 Gene

(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4467 Gene

No ASD Table

Relevant External Links for MIR4467 Gene

GeneLoc Exon Structure for
MIR4467
ECgene alternative splicing isoforms for
MIR4467

Expression for MIR4467 Gene

mRNA expression in normal human tissues for MIR4467 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4467 Gene:

MIR4467

mRNA Expression by UniProt/SwissProt for MIR4467 Gene:

Q9UFC0-LRWD1_HUMAN
Tissue specificity: Testis-specific. Drastically down-regulated in testis from patients with Sertoli cell-only syndrome (SCOS).
genes like me logo Genes that share expression patterns with MIR4467: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR4467 Gene

Orthologs for MIR4467 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR4467 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DKFZP434K1815 35
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LRWD1 35
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LRWD1 35
  • 53 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lrwd1 35
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LRWD1 35
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRWD1 35
  • 48 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii lrwd1 35
  • 35 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
OneToOne
Species where no ortholog for MIR4467 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR4467 Gene

ENSEMBL:
Gene Tree for MIR4467 (if available)
TreeFam:
Gene Tree for MIR4467 (if available)

Paralogs for MIR4467 Gene

No data available for Paralogs for MIR4467 Gene

Variants for MIR4467 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4467 Gene

Variant ID Type Subtype PubMed ID
dgv6538n100 CNV gain 25217958
nsv428182 CNV gain 18775914
nsv464664 CNV gain 19166990
nsv464665 CNV loss 19166990
nsv5879 CNV deletion 18451855
nsv607998 CNV gain+loss 21841781
nsv607999 CNV loss 21841781
nsv8192 CNV gain 18304495
nsv831083 CNV loss 17160897

Relevant External Links for MIR4467 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4467

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR4467 Gene

Disorders for MIR4467 Gene

Relevant External Links for MIR4467

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4467

No disorders were found for MIR4467 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4467 Gene

Publications for MIR4467 Gene

  1. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 65
  2. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 65
  3. Dynamic association of ORCA with prereplicative complex components regulates DNA replication initiation. (PMID: 22645314) Shen Z. … Prasanth S.G. (Mol. Cell. Biol. 2012) 4 65
  4. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 4 65
  5. Orc2 protects ORCA from ubiquitin-mediated degradation. (PMID: 22935713) Shen Z. … Prasanth S.G. (Cell Cycle 2012) 4 65

Products for MIR4467 Gene

Sources for MIR4467 Gene

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