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Aliases for MIR4459 Gene

Subcategory (RNA class) for MIR4459 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4459 Gene

  • MicroRNA 4459 2 3 5
  • Hsa-Mir-4459 3

External Ids for MIR4459 Gene

Previous GeneCards Identifiers for MIR4459 Gene

  • GC05U901573
  • GC05M053372

Summaries for MIR4459 Gene

Entrez Gene Summary for MIR4459 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4459 Gene

MIR4459 (MicroRNA 4459) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4459 Gene

Genomics for MIR4459 Gene

Regulatory Elements for MIR4459 Gene

Enhancers for MIR4459 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F054061 1.5 FANTOM5 Ensembl ENCODE 0.4 +12.3 12337 2.9 ELF3 SOX13 CTCF RAD21 ZNF644 RARA SCRT2 NR2F6 HOMEZ MAFK RN7SL801P MIR4459
GH05F054086 1 Ensembl ENCODE 0.4 -12.1 -12136 2.1 BHLHE40 FOS MNT MIR4459 GC05M054128
GH05F054049 0.5 ENCODE 0.3 +25.5 25461 0.8 RN7SL801P MIR4459
GH05F054090 1 Ensembl ENCODE 0.3 -15.3 -15347 0.5 CTCF PKNOX1 JUN BACH1 RAD21 CHAMP1 ZNF316 FOXK2 NFE2 FOS MIR4459 GC05M054128
GH05F054091 0.5 Ensembl 0.3 -16.1 -16119 0.6 SMARCA4 POLR2A BACH1 ZNF600 MIR4459 GC05M054128
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR4459 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4459 Gene

Chromosome:
5
Start:
54,075,518 bp from pter
End:
54,075,583 bp from pter
Size:
66 bases
Orientation:
Minus strand

Genomic View for MIR4459 Gene

Genes around MIR4459 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4459 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4459 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4459 Gene

Proteins for MIR4459 Gene

Post-translational modifications for MIR4459 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4459 Gene

Domains & Families for MIR4459 Gene

Gene Families for MIR4459 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4459: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4459 Gene

Function for MIR4459 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4459 Gene

Localization for MIR4459 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4459 Gene

Pathways & Interactions for MIR4459 Gene

SuperPathways for MIR4459 Gene

No Data Available

Interacting Proteins for MIR4459 Gene

Gene Ontology (GO) - Biological Process for MIR4459 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4459 Gene

Transcripts for MIR4459 Gene

mRNA/cDNA for MIR4459 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4459 Gene

No ASD Table

Relevant External Links for MIR4459 Gene

GeneLoc Exon Structure for
MIR4459
ECgene alternative splicing isoforms for
MIR4459

Expression for MIR4459 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4459 Gene:

MIR4459
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4459 Gene

Orthologs for MIR4459 Gene

Evolution for MIR4459 Gene

ENSEMBL:
Gene Tree for MIR4459 (if available)
TreeFam:
Gene Tree for MIR4459 (if available)

No data available for Orthologs for MIR4459 Gene

Paralogs for MIR4459 Gene

No data available for Paralogs for MIR4459 Gene

Variants for MIR4459 Gene

Sequence variations from dbSNP and Humsavar for MIR4459 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs112587718 -- 54,077,004(+) TTCTA(C/T)GCTAC intron-variant, upstream-variant-2KB
rs113638268 -- 54,076,045(+) CACAC(A/G)CACCA intron-variant, upstream-variant-2KB
rs113817701 -- 54,076,272(+) AAAAA(A/T)TAGCT intron-variant, upstream-variant-2KB
rs116006640 -- 54,075,540(+) TGCCA(C/T)GATCT intron-variant, nc-transcript-variant
rs13162796 -- 54,077,471(+) ATGTA(A/G)AGAAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4459 Gene

Variant ID Type Subtype PubMed ID
dgv5666n100 CNV gain 25217958
dgv5668n100 CNV gain 25217958
dgv9786n54 CNV gain 21841781
esv3570146 CNV loss 25503493
nsv4829 CNV insertion 18451855
nsv830299 CNV gain 17160897

Relevant External Links for MIR4459 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4459

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4459 Gene

Disorders for MIR4459 Gene

Relevant External Links for MIR4459

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4459

No disorders were found for MIR4459 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4459 Gene

Publications for MIR4459 Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima D.D. … Dave S.S. (Blood 2010) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4459 Gene

Sources for MIR4459 Gene

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