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Aliases for MIR4459 Gene

Subcategory (RNA class) for MIR4459 Gene


Quality Score for this RNA gene is


Aliases for MIR4459 Gene

  • MicroRNA 4459 2 3 5
  • Hsa-Mir-4459 3

External Ids for MIR4459 Gene

Previous GeneCards Identifiers for MIR4459 Gene

  • GC05U901573
  • GC05M053372

Summaries for MIR4459 Gene

Entrez Gene Summary for MIR4459 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4459 Gene

MIR4459 (MicroRNA 4459) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4459 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4459 Gene

Genomics for MIR4459 Gene

Regulatory Elements for MIR4459 Gene

Enhancers for MIR4459 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H054061 1.2 FANTOM5 Ensembl ENCODE 0.4 +12.3 12337 2 CTCF JUND POLR2A SCRT2 ZBTB33 MAFK RAD21 MIR4459 RN7SL801P
GH05H054090 0.8 ENCODE 0.4 -15.3 -15323 0 CTCF PKNOX1 JUN BACH1 RAD21 CHAMP1 FOSL1 ZNF316 FOXK2 FOS MIR4459 GC05M054128
GH05H054086 0.7 Ensembl ENCODE 0.4 -12.1 -12136 2 USF2 FOS MIR4459 GC05M054128
GH05H054091 0.4 Ensembl 0.4 -15.9 -15918 0 POLR2A BACH1 MIR4459 GC05M054128
GH05H054159 0.6 Ensembl 0.2 -83.8 -83818 0 CTCF PKNOX1 ATF1 ETV1 BHLHE40 RAD21 ZNF592 FOSL1 CREM SPI1 ENSG00000272416 GC05M054128 MIR4459
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4459 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4459 Gene

54,075,518 bp from pter
54,075,583 bp from pter
66 bases
Minus strand

Genomic View for MIR4459 Gene

Genes around MIR4459 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4459 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4459 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4459 Gene

Proteins for MIR4459 Gene

Post-translational modifications for MIR4459 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4459 Gene

Domains & Families for MIR4459 Gene

Gene Families for MIR4459 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4459: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4459 Gene

Function for MIR4459 Gene

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR4459
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4459 Gene

Localization for MIR4459 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4459 Gene

Pathways & Interactions for MIR4459 Gene

SuperPathways for MIR4459 Gene

No Data Available

Interacting Proteins for MIR4459 Gene

Gene Ontology (GO) - Biological Process for MIR4459 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR4459 Gene

Drugs & Compounds for MIR4459 Gene

No Compound Related Data Available

Transcripts for MIR4459 Gene

mRNA/cDNA for MIR4459 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR4459
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4459 Gene

No ASD Table

Relevant External Links for MIR4459 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR4459 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4459 Gene:

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4459 Gene

Orthologs for MIR4459 Gene

Evolution for MIR4459 Gene

Gene Tree for MIR4459 (if available)
Gene Tree for MIR4459 (if available)

No data available for Orthologs for MIR4459 Gene

Paralogs for MIR4459 Gene

No data available for Paralogs for MIR4459 Gene

Variants for MIR4459 Gene

Sequence variations from dbSNP and Humsavar for MIR4459 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000417387 -- 54,075,486(+) ATTCC(A/T)TTTTT intron-variant, downstream-variant-500B
rs1000522009 -- 54,076,520(+) CAATA(-/T)TAAAT intron-variant, upstream-variant-2KB
rs1002159534 -- 54,077,321(+) AAGTG(C/T)CTTAC intron-variant, upstream-variant-2KB
rs1002212142 -- 54,077,129(+) ATTGT(C/T)ATTCA intron-variant, upstream-variant-2KB
rs1003303105 -- 54,076,830(+) CATCC(A/G)TGGAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4459 Gene

Variant ID Type Subtype PubMed ID
dgv5666n100 CNV gain 25217958
dgv5668n100 CNV gain 25217958
dgv9786n54 CNV gain 21841781
esv3570146 CNV loss 25503493
nsv4829 CNV insertion 18451855
nsv830299 CNV gain 17160897

Relevant External Links for MIR4459 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4459 Gene

Disorders for MIR4459 Gene

Relevant External Links for MIR4459

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR4459 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4459 Gene

Publications for MIR4459 Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3 60
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 60

Products for MIR4459 Gene

Sources for MIR4459 Gene

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