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Aliases for MIR4458 Gene

Subcategory (RNA class) for MIR4458 Gene


Quality Score for this RNA gene is


Aliases for MIR4458 Gene

  • MicroRNA 4458 2 3 5
  • Hsa-Mir-4458 3
  • Mir-4458 3

External Ids for MIR4458 Gene

Previous GeneCards Identifiers for MIR4458 Gene

  • GC05U901570
  • GC05P008461
  • GC05P008451

Summaries for MIR4458 Gene

Entrez Gene Summary for MIR4458 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4458 Gene

MIR4458 (MicroRNA 4458) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4458 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4458 Gene

Genomics for MIR4458 Gene

GeneHancer (GH) Regulatory Elements for MIR4458 Gene

Promoters and enhancers for MIR4458 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I008523 Enhancer 0.2 ENCODE 0.2 +62.7 62696 1 LOC105374647 MIR4458
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR4458 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4458 Gene

Genomic Locations for MIR4458 Gene
75 bases
Plus strand

Genomic View for MIR4458 Gene

Genes around MIR4458 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4458 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4458 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4458 Gene

Proteins for MIR4458 Gene

Post-translational modifications for MIR4458 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4458 Gene

Domains & Families for MIR4458 Gene

Gene Families for MIR4458 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4458: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4458 Gene

Function for MIR4458 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4458 Gene

Localization for MIR4458 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4458 Gene

Pathways & Interactions for MIR4458 Gene

SuperPathways for MIR4458 Gene

No Data Available

Interacting Proteins for MIR4458 Gene

Gene Ontology (GO) - Biological Process for MIR4458 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR4458 Gene

Drugs & Compounds for MIR4458 Gene

No Compound Related Data Available

Transcripts for MIR4458 Gene

mRNA/cDNA for MIR4458 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4458 Gene

No ASD Table

Relevant External Links for MIR4458 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR4458 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4458 Gene:

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4458 Gene

Orthologs for MIR4458 Gene

Evolution for MIR4458 Gene

Gene Tree for MIR4458 (if available)
Gene Tree for MIR4458 (if available)

No data available for Orthologs for MIR4458 Gene

Paralogs for MIR4458 Gene

No data available for Paralogs for MIR4458 Gene

Variants for MIR4458 Gene

Sequence variations from dbSNP and Humsavar for MIR4458 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1003088766 -- 8,461,472(+) T/C downstream_transcript_variant
rs1003237085 -- 8,461,404(+) T/G downstream_transcript_variant
rs1003424670 -- 8,459,962(+) C/T upstream_transcript_variant
rs1005677076 -- 8,461,326(+) G/A downstream_transcript_variant
rs1006485967 -- 8,460,667(+) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4458 Gene

Variant ID Type Subtype PubMed ID
esv3569957 CNV loss 25503493
nsv597003 CNV gain 21841781

Additional Variant Information for MIR4458 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4458 Gene

Disorders for MIR4458 Gene

Additional Disease Information for MIR4458

No disorders were found for MIR4458 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4458 Gene

Publications for MIR4458 Gene

  1. miR-4458 suppresses glycolysis and lactate production by directly targeting hexokinase2 in colon cancer cells. (PMID: 26607110) Qin Y … Wang Y (Biochemical and biophysical research communications 2016) 3 58
  2. Burkholderia pseudomallei survival in lung epithelial cells benefits from miRNA-mediated suppression of ATG10. (PMID: 26151773) Li Q … Mao XH (Autophagy 2015) 3 58
  3. Tumor-suppressing effect of miR-4458 on human hepatocellular carcinoma. (PMID: 25833000) Tang D … Zhu L (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015) 3 58
  4. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 58
  5. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3 58

Products for MIR4458 Gene

Sources for MIR4458 Gene

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