Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR4457 Gene

Subcategory (RNA class) for MIR4457 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4457 Gene

  • MicroRNA 4457 2 3
  • Hsa-Mir-4457 3

External Ids for MIR4457 Gene

Summaries for MIR4457 Gene

Entrez Gene Summary for MIR4457 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4457 Gene

MIR4457 (MicroRNA 4457) is a RNA Gene, and belongs to miRNA RNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4457 Gene

Genomics for MIR4457 Gene

Genomic Location for MIR4457 Gene

Start:
1,309,310 bp from pter
End:
1,309,377 bp from pter
Size:
68 bases
Orientation:
Minus strand

Genomic View for MIR4457 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR4457 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4457 Gene

No data available for Regulatory Elements for MIR4457 Gene

Proteins for MIR4457 Gene

Post-translational modifications for MIR4457 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4457 Gene

Domains for MIR4457 Gene

Gene Families for MIR4457 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs
genes like me logo Genes that share domains with MIR4457: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for MIR4457 Gene

Function for MIR4457 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR4457 Gene

Localization for MIR4457 Gene

No data available for Gene Ontology (GO) - Cellular Components for MIR4457 Gene

Pathways for MIR4457 Gene

SuperPathways for MIR4457 Gene

No Data Available

Interacting Proteins for MIR4457 Gene

Gene Ontology (GO) - Biological Process for MIR4457 Gene

None

No data available for Pathways by source for MIR4457 Gene

Transcripts for MIR4457 Gene

mRNA/cDNA for MIR4457 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4457 Gene

No ASD Table

Relevant External Links for MIR4457 Gene

GeneLoc Exon Structure for
MIR4457
ECgene alternative splicing isoforms for
MIR4457

Expression for MIR4457 Gene

No Expression Related Data Available

Orthologs for MIR4457 Gene

Evolution for MIR4457 Gene

ENSEMBL:
Gene Tree for MIR4457 (if available)
TreeFam:
Gene Tree for MIR4457 (if available)

No data available for Orthologs for MIR4457 Gene

Paralogs for MIR4457 Gene

No data available for Paralogs for MIR4457 Gene

Variants for MIR4457 Gene

Sequence variations from dbSNP and Humsavar for MIR4457 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs6554758 -- 1,310,037(+) caaac(A/G)aacaa upstream-variant-2KB
rs12332579 -- 1,311,083(+) AGAAT(C/T)TTGGG upstream-variant-2KB
rs34947319 -- 1,308,964(-) TTCCG(C/T)GTGTT downstream-variant-500B
rs35683488 -- 1,310,284(+) GCTTT(C/T)TCAGA upstream-variant-2KB
rs56335551 -- 1,310,991(+) AAAAA(-/A)GCACA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4457 Gene

Variant ID Type Subtype PubMed ID
nsv881117 CNV Loss 21882294
nsv510895 CNV Complex 20534489
nsv880847 CNV Loss 21882294
nsv822959 CNV Loss 20364138
nsv509045 CNV Insertion 20534489
nsv880418 CNV Loss 21882294
nsv881444 CNV Loss 21882294

Relevant External Links for MIR4457 Gene

HapMap Linkage Disequilibrium report
MIR4457

Disorders for MIR4457 Gene

No disorders were found for MIR4457 Gene.

No data available for UniProtKB/Swiss-Prot for MIR4457 Gene

Publications for MIR4457 Gene

  1. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  2. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima D.D. … Dave S.S. (Blood 2010) 3

Products for MIR4457 Gene

Sources for MIR4457 Gene

Back to Top

Content