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Aliases for MIR4457 Gene

Subcategory (RNA class) for MIR4457 Gene


Quality Score for this RNA gene is


Aliases for MIR4457 Gene

  • MicroRNA 4457 2 3 5
  • Hsa-Mir-4457 3
  • Mir-4457 3

External Ids for MIR4457 Gene

Previous GeneCards Identifiers for MIR4457 Gene

  • GC05U901568

Summaries for MIR4457 Gene

Entrez Gene Summary for MIR4457 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4457 Gene

MIR4457 (MicroRNA 4457) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4457 Gene

Genomics for MIR4457 Gene

Regulatory Elements for MIR4457 Gene

Enhancers for MIR4457 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MIR4457 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4457 Gene

1,309,310 bp from pter
1,309,377 bp from pter
68 bases
Minus strand

Genomic View for MIR4457 Gene

Genes around MIR4457 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4457 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4457 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4457 Gene

Proteins for MIR4457 Gene

Post-translational modifications for MIR4457 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4457 Gene

Domains & Families for MIR4457 Gene

Gene Families for MIR4457 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4457: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4457 Gene

Function for MIR4457 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4457 Gene

Localization for MIR4457 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4457 Gene

Pathways & Interactions for MIR4457 Gene

SuperPathways for MIR4457 Gene

No Data Available

Interacting Proteins for MIR4457 Gene

Gene Ontology (GO) - Biological Process for MIR4457 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR4457 Gene

Drugs & Compounds for MIR4457 Gene

No Compound Related Data Available

Transcripts for MIR4457 Gene

mRNA/cDNA for MIR4457 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4457 Gene

No ASD Table

Relevant External Links for MIR4457 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR4457 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR4457 Gene

Orthologs for MIR4457 Gene

Evolution for MIR4457 Gene

Gene Tree for MIR4457 (if available)
Gene Tree for MIR4457 (if available)

No data available for Orthologs for MIR4457 Gene

Paralogs for MIR4457 Gene

No data available for Paralogs for MIR4457 Gene

Variants for MIR4457 Gene

Sequence variations from dbSNP and Humsavar for MIR4457 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs76597939 -- 1,309,641(+) GCTGC(A/G)GTAAG upstream-variant-2KB
rs6554758 -- 1,310,037(+) caaac(A/G)aacaa upstream-variant-2KB
rs34947319 -- 1,308,964(-) TTCCG(C/T)GTGTT downstream-variant-500B
rs60622800 -- 1,309,789(+) TGGGA(A/G)GCTGA upstream-variant-2KB
rs115769169 -- 1,309,319(+) TACGC(C/T)AGTCA nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4457 Gene

Variant ID Type Subtype PubMed ID
nsv881117 CNV Loss 21882294
nsv510895 CNV Complex 20534489
nsv880847 CNV Loss 21882294
nsv822959 CNV Loss 20364138
nsv509045 CNV Insertion 20534489
nsv880418 CNV Loss 21882294
nsv881444 CNV Loss 21882294

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for MIR4457 Gene

Disorders for MIR4457 Gene

Relevant External Links for MIR4457

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR4457 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4457 Gene

Publications for MIR4457 Gene

  1. Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. (PMID: 25086665) Wolpin B.M. … Amundadottir L.T. (Nat. Genet. 2014) 3 67
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3
  3. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima D.D. … Dave S.S. (Blood 2010) 3
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3

Products for MIR4457 Gene

Sources for MIR4457 Gene