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Aliases for MIR4456 Gene

Subcategory (RNA class) for MIR4456 Gene


Quality Score for this RNA gene is


Aliases for MIR4456 Gene

  • MicroRNA 4456 2 3 5
  • Hsa-Mir-4456 3

External Ids for MIR4456 Gene

Previous GeneCards Identifiers for MIR4456 Gene

  • GC05U901577

Summaries for MIR4456 Gene

Entrez Gene Summary for MIR4456 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4456 Gene

MIR4456 (MicroRNA 4456) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4456 Gene

Genomics for MIR4456 Gene

Regulatory Elements for MIR4456 Gene

Enhancers for MIR4456 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F000531 0.5 Ensembl 0.8 +4.6 4582 0.2 GLIS2 GLIS1 ZIC2 MIR4456 ENSG00000250385
GH05F000527 1 Ensembl ENCODE 0.4 +6.6 6607 3.5 CTCF PKNOX1 SUZ12 MAX E2F1 GATA3 ARID3A CTBP1 ZNF600 RCOR1 SLC9A3 CEP72 SLC6A3 ENSG00000250385 MIR4456
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4456 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4456 Gene

535,840 bp from pter
535,882 bp from pter
43 bases
Minus strand

Genomic View for MIR4456 Gene

Genes around MIR4456 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4456 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4456 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4456 Gene

Proteins for MIR4456 Gene

Post-translational modifications for MIR4456 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4456 Gene

Domains & Families for MIR4456 Gene

Gene Families for MIR4456 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4456: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4456 Gene

Function for MIR4456 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4456 Gene

Localization for MIR4456 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4456 Gene

Pathways & Interactions for MIR4456 Gene

SuperPathways for MIR4456 Gene

No Data Available

Interacting Proteins for MIR4456 Gene

Gene Ontology (GO) - Biological Process for MIR4456 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR4456 Gene

Transcripts for MIR4456 Gene

mRNA/cDNA for MIR4456 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4456 Gene

No ASD Table

Relevant External Links for MIR4456 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR4456 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4456 Gene:

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4456 Gene

Orthologs for MIR4456 Gene

Evolution for MIR4456 Gene

Gene Tree for MIR4456 (if available)
Gene Tree for MIR4456 (if available)

No data available for Orthologs for MIR4456 Gene

Paralogs for MIR4456 Gene

No data available for Paralogs for MIR4456 Gene

Variants for MIR4456 Gene

Sequence variations from dbSNP and Humsavar for MIR4456 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs111436063 -- 537,613(+) GGTGC(-/GGC)CAGCC upstream-variant-2KB
rs112011482 -- 536,933(+) CGTTG(A/T)GCATT upstream-variant-2KB
rs112739584 -- 536,500(+) TGAGC(A/G)TTGTG upstream-variant-2KB
rs114361576 -- 536,098(+) AGAGC(C/T)GCAGA upstream-variant-2KB
rs114381271 -- 537,222(+) GACGC(C/T)GCACA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4456 Gene

Variant ID Type Subtype PubMed ID
nsv950619 CNV deletion 24416366
nsv822926 CNV gain 20364138
nsv596629 CNV gain 21841781
nsv596628 CNV gain 21841781
nsv596626 CNV gain 21841781
nsv509042 CNV insertion 20534489
nsv461890 CNV gain 19166990
nsv461889 CNV gain 19166990
nsv1147234 OTHER inversion 26484159
nsv1133013 OTHER inversion 24896259
nsv1032584 CNV gain 25217958
nsv1019215 CNV gain 25217958
esv3894107 CNV gain 25118596
esv3603754 CNV gain 21293372
esv3603750 CNV gain 21293372
esv2759315 CNV loss 17122850
esv2752071 CNV gain 17911159
dgv9479n54 CNV gain 21841781

Relevant External Links for MIR4456 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4456 Gene

Disorders for MIR4456 Gene

Relevant External Links for MIR4456

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR4456 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4456 Gene

Publications for MIR4456 Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima D.D. … Dave S.S. (Blood 2010) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4456 Gene

Sources for MIR4456 Gene

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