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Aliases for MIR4454 Gene

Subcategory (RNA class) for MIR4454 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4454 Gene

  • MicroRNA 4454 2 3 5
  • Hsa-Mir-4454 3

External Ids for MIR4454 Gene

Previous GeneCards Identifiers for MIR4454 Gene

  • GC04U901515
  • GC04M164016

Summaries for MIR4454 Gene

Entrez Gene Summary for MIR4454 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4454 Gene

MIR4454 (MicroRNA 4454) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4454 Gene

Genomics for MIR4454 Gene

Regulatory Elements for MIR4454 Gene

Enhancers for MIR4454 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F163094 0.2 Ensembl 0.8 -1.1 -1073 0.2 MIR4454 LOC101928081
GH04F163063 0.4 ENCODE 0.3 +29.6 29565 0.2 GFI1B FOS LOC101928081 MIR4454 ENSG00000251123
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4454 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4454 Gene

Chromosome:
4
Start:
163,093,574 bp from pter
End:
163,093,628 bp from pter
Size:
55 bases
Orientation:
Minus strand

Genomic View for MIR4454 Gene

Genes around MIR4454 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4454 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4454 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4454 Gene

Proteins for MIR4454 Gene

Post-translational modifications for MIR4454 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4454 Gene

Domains & Families for MIR4454 Gene

Gene Families for MIR4454 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4454: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4454 Gene

Function for MIR4454 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4454 Gene

Localization for MIR4454 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4454 Gene

Pathways & Interactions for MIR4454 Gene

SuperPathways for MIR4454 Gene

No Data Available

Interacting Proteins for MIR4454 Gene

Gene Ontology (GO) - Biological Process for MIR4454 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4454 Gene

Transcripts for MIR4454 Gene

mRNA/cDNA for MIR4454 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4454 Gene

No ASD Table

Relevant External Links for MIR4454 Gene

GeneLoc Exon Structure for
MIR4454
ECgene alternative splicing isoforms for
MIR4454

Expression for MIR4454 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4454 Gene

mRNA differential expression in normal tissues according to GTEx for MIR4454 Gene

This gene is overexpressed in Breast - Mammary Tissue (x10.4), Esophagus - Mucosa (x8.5), Vagina (x5.9), Minor Salivary Gland (x5.5), and Skin - Sun Exposed (Lower leg) (x4.6).

NURSA nuclear receptor signaling pathways regulating expression of MIR4454 Gene:

MIR4454
genes like me logo Genes that share expression patterns with MIR4454: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4454 Gene

Orthologs for MIR4454 Gene

Evolution for MIR4454 Gene

ENSEMBL:
Gene Tree for MIR4454 (if available)
TreeFam:
Gene Tree for MIR4454 (if available)

No data available for Orthologs for MIR4454 Gene

Paralogs for MIR4454 Gene

No data available for Paralogs for MIR4454 Gene

Variants for MIR4454 Gene

Sequence variations from dbSNP and Humsavar for MIR4454 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs111457659 -- 163,093,286(+) ACTGA(C/T)GACAT downstream-variant-500B
rs112605388 -- 163,095,542(+) TTAGC(A/G)GCTGA upstream-variant-2KB
rs112703931 -- 163,095,612(+) TCTCA(C/G)AGTGG upstream-variant-2KB
rs139702409 -- 163,093,294(+) CATTC(C/T)ACCAT downstream-variant-500B
rs140493655 -- 163,093,523(+) CAGCC(C/T)ACCTG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR4454 Gene

Variant ID Type Subtype PubMed ID
nsv830206 CNV gain 17160897
nsv823004 CNV gain 20364138
nsv7198 OTHER inversion 18451855
nsv597160 CNV loss 21841781
nsv597159 CNV loss 21841781
nsv597158 CNV loss 21841781
nsv597157 CNV loss 21841781
nsv549299 CNV gain 21841781
nsv526392 CNV gain 19592680
nsv520673 CNV loss 19592680
nsv517486 CNV gain+loss 19592680
nsv510896 OTHER complex 20534489
nsv509053 CNV insertion 20534489
nsv4703 CNV insertion 18451855
nsv461978 CNV loss 19166990
nsv4584 CNV insertion 18451855
nsv428463 CNV loss 18775914
nsv1047309 CNV gain 25217958
nsv1042376 CNV gain 25217958
nsv1034539 CNV loss 25217958
nsv1030184 CNV loss 25217958
nsv1018954 CNV loss 25217958
nsv1015505 CNV gain 25217958
esv3894131 CNV gain 25118596
esv3894064 CNV gain 25118596
esv3606878 CNV loss 21293372
esv3604044 CNV loss 21293372
esv3602952 CNV loss 21293372
esv3602948 CNV gain 21293372
esv3576050 CNV gain 25503493
esv3569988 CNV loss 25503493
esv22341 CNV gain+loss 19812545
esv1001030 CNV gain 20482838
dgv691n27 CNV loss 19166990
dgv5571n100 CNV loss 25217958

Relevant External Links for MIR4454 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4454

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4454 Gene

Disorders for MIR4454 Gene

Relevant External Links for MIR4454

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4454

No disorders were found for MIR4454 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4454 Gene

Publications for MIR4454 Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima D.D. … Dave S.S. (Blood 2010) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4454 Gene

Sources for MIR4454 Gene

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