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Aliases for MIR4453 Gene

Subcategory (RNA class) for MIR4453 Gene


Quality Score for this RNA gene is


Aliases for MIR4453 Gene

  • MicroRNA 4453 2 3 5
  • Hsa-Mir-4453 3

External Ids for MIR4453 Gene

ORGUL Members for MIR4453 Gene

Previous GeneCards Identifiers for MIR4453 Gene

  • GC04U901506
  • GC04P153458

Summaries for MIR4453 Gene

Entrez Gene Summary for MIR4453 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4453 Gene

MIR4453 (MicroRNA 4453) is an RNA Gene, and is affiliated with the antisense RNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4453 Gene

Genomics for MIR4453 Gene

Regulatory Elements for MIR4453 Gene

Enhancers for MIR4453 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F153151 0.6 ENCODE 17.9 +616.9 616943 3.1 TBP FEZF1 GLI4 GLIS2 FOS EGR2 SP3 USF2 CEBPB RAD51 MIR4453 MND1 ENSG00000201786 RNU6-1196P TRIM2 GC04M153152
GH04F151886 0.2 Ensembl 17.3 -648.4 -648440 2.0 PKNOX1 WRNIP1 ZNF140 BMI1 ZNF644 RELA POLR2A EED ETV6 CREM MIR4453 ENSG00000249818 ENSG00000249708 ENSG00000249184
GH04F152090 0.8 Ensembl ENCODE 15.4 -445.6 -445564 0.6 ZNF585B HMBOX1 MIR4453 LOC100996286 GC04P152041
GH04F153114 1.4 FANTOM5 Ensembl ENCODE 15.4 +579.8 579806 3.7 JUN JUND ZNF585B HMBOX1 FOS MAFK TCF7L2 SPI1 TRIM2 MIR4453 KIAA0922 TIGD4 GC04P153070 GC04P153071
GH04F152945 0.2 ENCODE 15.4 +410.3 410291 1.8 ZNF707 SMARCA4 ZNF585B POLR2A IKZF1 SPI1 MIR4453 GC04P152944 PIR52121
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR4453 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4453 Gene

152,536,264 bp from pter
152,539,263 bp from pter
3,000 bases
Plus strand

Genomic View for MIR4453 Gene

Genes around MIR4453 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4453 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4453 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4453 Gene

Proteins for MIR4453 Gene

Post-translational modifications for MIR4453 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4453 Gene

Domains & Families for MIR4453 Gene

Gene Families for MIR4453 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4453: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4453 Gene

Function for MIR4453 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4453 Gene

Localization for MIR4453 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4453 Gene

Pathways & Interactions for MIR4453 Gene

SuperPathways for MIR4453 Gene

No Data Available

Interacting Proteins for MIR4453 Gene

Gene Ontology (GO) - Biological Process for MIR4453 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR4453 Gene

Transcripts for MIR4453 Gene

mRNA/cDNA for MIR4453 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4453 Gene

No ASD Table

Relevant External Links for MIR4453 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR4453 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4453 Gene:

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4453 Gene

Orthologs for MIR4453 Gene

Evolution for MIR4453 Gene

Gene Tree for MIR4453 (if available)
Gene Tree for MIR4453 (if available)

No data available for Orthologs for MIR4453 Gene

Paralogs for MIR4453 Gene

No data available for Paralogs for MIR4453 Gene

Variants for MIR4453 Gene

Sequence variations from dbSNP and Humsavar for MIR4453 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs111337137 -- 152,536,109(+) GAGAG(A/C)GGCGC upstream-variant-2KB
rs112987232 -- 152,535,266(+) CGGCC(C/T)CCCGG upstream-variant-2KB, utr-variant-5-prime
rs113998395 -- 152,536,010(+) GCGGC(A/G)GCGGC upstream-variant-2KB, utr-variant-5-prime
rs1351903 -- 152,534,950(+) TTAGA(A/G)AAGAG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs138892570 -- 152,534,807(+) TCCCC(A/C/G)CTCCG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4453 Gene

Variant ID Type Subtype PubMed ID
nsv830116 CNV gain 17160897

Relevant External Links for MIR4453 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4453 Gene

Disorders for MIR4453 Gene

Relevant External Links for MIR4453

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR4453 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4453 Gene

Publications for MIR4453 Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima D.D. … Dave S.S. (Blood 2010) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4453 Gene

Sources for MIR4453 Gene

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