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Aliases for MIR4453 Gene

Subcategory (RNA class) for MIR4453 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4453 Gene

  • MicroRNA 4453 2 3 5
  • Hsa-Mir-4453 3

External Ids for MIR4453 Gene

Previous GeneCards Identifiers for MIR4453 Gene

  • GC04U901506
  • GC04P153458

Summaries for MIR4453 Gene

Entrez Gene Summary for MIR4453 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4453 Gene

MIR4453 (MicroRNA 4453) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4453 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4453 Gene

Genomics for MIR4453 Gene

GeneHancer (GH) Regulatory Elements for MIR4453 Gene

Promoters and enhancers for MIR4453 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I152533 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.2 -189 4.7 HDGF PKNOX1 CLOCK MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 FBXW7 MIR4453 MIR4453HG
GH04I152543 Enhancer 0.2 dbSUPER 0.4 +8.1 8051 1.2 MIR4453 RPS3AP18
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR4453 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4453 Gene

Genomic Locations for MIR4453 Gene
chr4:152,536,428-152,536,516
(GRCh38/hg38)
Size:
89 bases
Orientation:
Plus strand
chr4:153,457,416-153,460,415
(GRCh37/hg19)

Genomic View for MIR4453 Gene

Genes around MIR4453 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4453 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4453 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4453 Gene

Proteins for MIR4453 Gene

Post-translational modifications for MIR4453 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4453 Gene

Domains & Families for MIR4453 Gene

Gene Families for MIR4453 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4453: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4453 Gene

Function for MIR4453 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4453 Gene

Localization for MIR4453 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4453 Gene

Pathways & Interactions for MIR4453 Gene

SuperPathways for MIR4453 Gene

No Data Available

Interacting Proteins for MIR4453 Gene

Gene Ontology (GO) - Biological Process for MIR4453 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4453 Gene

Drugs & Compounds for MIR4453 Gene

No Compound Related Data Available

Transcripts for MIR4453 Gene

mRNA/cDNA for MIR4453 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4453 Gene

No ASD Table

Relevant External Links for MIR4453 Gene

GeneLoc Exon Structure for
MIR4453
ECgene alternative splicing isoforms for
MIR4453

Expression for MIR4453 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4453 Gene:

MIR4453
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4453 Gene

Orthologs for MIR4453 Gene

Evolution for MIR4453 Gene

ENSEMBL:
Gene Tree for MIR4453 (if available)
TreeFam:
Gene Tree for MIR4453 (if available)

No data available for Orthologs for MIR4453 Gene

Paralogs for MIR4453 Gene

No data available for Paralogs for MIR4453 Gene

Variants for MIR4453 Gene

Sequence variations from dbSNP and Humsavar for MIR4453 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000489493 -- 152,536,008(+) G/A upstream_transcript_variant
rs1001035776 -- 152,535,274(+) C/A/T upstream_transcript_variant
rs1001227453 -- 152,535,830(+) G/C upstream_transcript_variant
rs1002180817 -- 152,535,039(+) G/A upstream_transcript_variant
rs1002233292 -- 152,534,946(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4453 Gene

Variant ID Type Subtype PubMed ID
nsv830116 CNV gain 17160897

Additional Variant Information for MIR4453 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4453

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4453 Gene

Disorders for MIR4453 Gene

Additional Disease Information for MIR4453

No disorders were found for MIR4453 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4453 Gene

Publications for MIR4453 Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3 58
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR4453 Gene

Sources for MIR4453 Gene

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