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Aliases for MIR4452 Gene

Subcategory (RNA class) for MIR4452 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4452 Gene

  • MicroRNA 4452 2 3 5
  • Hsa-Mir-4452 3

External Ids for MIR4452 Gene

Previous GeneCards Identifiers for MIR4452 Gene

  • GC04U901495
  • GC04M087464

Summaries for MIR4452 Gene

Entrez Gene Summary for MIR4452 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4452 Gene

MIR4452 (MicroRNA 4452) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4452 Gene

Genomics for MIR4452 Gene

Regulatory Elements for MIR4452 Gene

Enhancers for MIR4452 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F086543 0.2 ENCODE 0.8 -1.4 -1441 1.1 ZNF362 MTA2 JUNB ZNF384 TBX21 GABPA ZFHX2 CBX5 NFYB STAT3 PTPN13 HSD17B13 MIR4452 MAPK10
GH04F086556 1.4 Ensembl ENCODE 0.3 -15.7 -15654 2.8 PKNOX1 INSM2 FEZF1 ZNF2 ZNF391 CREM ZNF362 OVOL3 JUNB ZEB2 PTPN13 MAPK10 MIR4452
GH04F086508 1.1 Ensembl ENCODE 0.3 +34.0 33996 1.0 ZNF121 ZNF366 ZNF512 ZBTB33 PRDM1 PTPN13 MAPK10 SLC10A6 HSD17B13 LOC260422 MIR4452 RN7SKP96
GH04F086582 0.6 Ensembl 0.3 -39.8 -39849 0.8 ZNF664 IKZF1 PRDM10 ZBTB17 PTPN13 MAPK10 MIR4452
GH04F086585 0.8 Ensembl ENCODE 0.2 -44.0 -44031 3.1 CTCF KLF1 PKNOX1 MTA2 ZNF664 OSR2 JUND RAD51 EED IKZF1 PTPN13 MAPK10 HSD17B13 MIR4452
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR4452 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4452 Gene

Chromosome:
4
Start:
86,542,482 bp from pter
End:
86,542,552 bp from pter
Size:
71 bases
Orientation:
Minus strand

Genomic View for MIR4452 Gene

Genes around MIR4452 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4452 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4452 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4452 Gene

Proteins for MIR4452 Gene

Post-translational modifications for MIR4452 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4452 Gene

Domains & Families for MIR4452 Gene

Gene Families for MIR4452 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4452: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4452 Gene

Function for MIR4452 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4452 Gene

Localization for MIR4452 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4452 Gene

Pathways & Interactions for MIR4452 Gene

SuperPathways for MIR4452 Gene

No Data Available

Interacting Proteins for MIR4452 Gene

Gene Ontology (GO) - Biological Process for MIR4452 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4452 Gene

Transcripts for MIR4452 Gene

mRNA/cDNA for MIR4452 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4452 Gene

No ASD Table

Relevant External Links for MIR4452 Gene

GeneLoc Exon Structure for
MIR4452
ECgene alternative splicing isoforms for
MIR4452

Expression for MIR4452 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4452 Gene:

MIR4452
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4452 Gene

Orthologs for MIR4452 Gene

Evolution for MIR4452 Gene

ENSEMBL:
Gene Tree for MIR4452 (if available)
TreeFam:
Gene Tree for MIR4452 (if available)

No data available for Orthologs for MIR4452 Gene

Paralogs for MIR4452 Gene

No data available for Paralogs for MIR4452 Gene

Variants for MIR4452 Gene

Sequence variations from dbSNP and Humsavar for MIR4452 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs111462603 -- 86,544,422(+) CCTAC(A/T)TACTA intron-variant, upstream-variant-2KB
rs113368122 -- 86,543,033(+) GGAAG(A/G/T)TTCAC intron-variant, upstream-variant-2KB
rs115430586 -- 86,542,676(+) CAGGT(C/T)CCAAC intron-variant, upstream-variant-2KB
rs116060894 -- 86,542,860(+) GAAGG(C/G)ACACT intron-variant, upstream-variant-2KB
rs116170019 -- 86,544,312(+) AACAA(A/G)AAGGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4452 Gene

Variant ID Type Subtype PubMed ID
esv2759264 CNV loss 17122850
nsv4411 CNV insertion 18451855
nsv594786 CNV gain 21841781
nsv594787 CNV gain 21841781

Relevant External Links for MIR4452 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4452

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4452 Gene

Disorders for MIR4452 Gene

Relevant External Links for MIR4452

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4452

No disorders were found for MIR4452 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4452 Gene

Publications for MIR4452 Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima D.D. … Dave S.S. (Blood 2010) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4452 Gene

Sources for MIR4452 Gene

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