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Aliases for MIR4451 Gene

Subcategory (RNA class) for MIR4451 Gene


Quality Score for this RNA gene is


Aliases for MIR4451 Gene

  • MicroRNA 4451 2 3 5
  • Hsa-Mir-4451 3
  • Mir-4451 3

External Ids for MIR4451 Gene

Previous GeneCards Identifiers for MIR4451 Gene

  • GC04U901501
  • GC04P086645

Summaries for MIR4451 Gene

Entrez Gene Summary for MIR4451 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4451 Gene

MIR4451 (MicroRNA 4451) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4451 Gene

Genomics for MIR4451 Gene

Regulatory Elements for MIR4451 Gene

Enhancers for MIR4451 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F085724 1.4 FANTOM5 Ensembl ENCODE 0.8 +3.2 3233 3.0 HDAC1 GATA2 ETV6 CREM JUNB TBX21 NR2F2 MBD2 SMARCA4 IKZF1 MIR4451 GC04P085763
GH04F085720 0.6 ENCODE 0.8 -1.5 -1502 1.1 JUND MTA2 NBN FOS TBX21 ZBTB40 MIR4451 LOC105377319
GH04F085740 1.5 FANTOM5 Ensembl ENCODE 0.3 +20.3 20252 5.0 PKNOX1 ARNT GATA2 FOS CREM CEBPB JUNB MAFF SMARCA4 PBX2 ARHGAP24 GC04P085763 MIR4451
GH04F085759 1.4 FANTOM5 Ensembl ENCODE 0.3 +39.7 39679 4.7 PKNOX1 JUN FEZF1 CEBPG ZNF121 CTBP1 GATA3 ZNF366 POLR2A SCRT2 ARHGAP24 ENSG00000273389 GC04P085763 MIR4451
GH04F085733 1 Ensembl ENCODE 0.4 +11.9 11933 2.0 HDAC1 JUN PYGO2 ZEB1 CCNT2 ELK1 GATA2 NFE2 FOS TCF7L2 ARHGAP24 MIR4451 GC04P085763
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4451 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4451 Gene

85,722,468 bp from pter
85,722,533 bp from pter
66 bases
Plus strand

Genomic View for MIR4451 Gene

Genes around MIR4451 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4451 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4451 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4451 Gene

Proteins for MIR4451 Gene

Post-translational modifications for MIR4451 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4451 Gene

Domains & Families for MIR4451 Gene

Gene Families for MIR4451 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4451: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4451 Gene

Function for MIR4451 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4451 Gene

Localization for MIR4451 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4451 Gene

Pathways & Interactions for MIR4451 Gene

SuperPathways for MIR4451 Gene

No Data Available

Interacting Proteins for MIR4451 Gene

Gene Ontology (GO) - Biological Process for MIR4451 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR4451 Gene

Transcripts for MIR4451 Gene

mRNA/cDNA for MIR4451 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4451 Gene

No ASD Table

Relevant External Links for MIR4451 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR4451 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4451 Gene:

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4451 Gene

Orthologs for MIR4451 Gene

Evolution for MIR4451 Gene

Gene Tree for MIR4451 (if available)
Gene Tree for MIR4451 (if available)

No data available for Orthologs for MIR4451 Gene

Paralogs for MIR4451 Gene

No data available for Paralogs for MIR4451 Gene

Variants for MIR4451 Gene

Sequence variations from dbSNP and Humsavar for MIR4451 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs112808354 -- 85,722,300(+) ACAAG(C/G)GGTTA intron-variant, upstream-variant-2KB
rs113214656 -- 85,721,536(+) AAAGA(A/C)TATCT intron-variant, upstream-variant-2KB
rs113884224 -- 85,720,797(+) AGAAA(A/C)CAAAG intron-variant, upstream-variant-2KB
rs11409263 -- 85,721,406(+) AAAAA(-/A)GAAAA intron-variant, upstream-variant-2KB
rs114538919 -- 85,722,313(+) GGTTG(A/G)ATGCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4451 Gene

Variant ID Type Subtype PubMed ID
nsv461566 CNV gain 19166990
nsv470048 CNV gain 18288195
nsv594747 CNV gain 21841781
nsv829999 CNV gain 17160897

Relevant External Links for MIR4451 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4451 Gene

Disorders for MIR4451 Gene

Relevant External Links for MIR4451

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR4451 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4451 Gene

Publications for MIR4451 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  2. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima D.D. … Dave S.S. (Blood 2010) 3 64
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4451 Gene

Sources for MIR4451 Gene

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