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Aliases for MIR4450 Gene

Subcategory (RNA class) for MIR4450 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4450 Gene

  • MicroRNA 4450 2 3 5
  • Hsa-Mir-4450 3
  • Mir-4450 3

External Ids for MIR4450 Gene

Previous GeneCards Identifiers for MIR4450 Gene

  • GC04U901504
  • GC04P077498

Summaries for MIR4450 Gene

Entrez Gene Summary for MIR4450 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4450 Gene

MIR4450 (MicroRNA 4450) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4450 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4450 Gene

Genomics for MIR4450 Gene

GeneHancer (GH) Regulatory Elements for MIR4450 Gene

Promoters and enhancers for MIR4450 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I076569 Enhancer 1.3 Ensembl ENCODE dbSUPER 0.8 -3.2 -3214 2.3 PKNOX1 FOXA2 ARID4B ETS1 YY1 ATF7 FOS RXRA REST PPARG RNU6-145P SHROOM3 ENSG00000231335 MIR4450 GC04M076533
GH04I076561 Enhancer 1.1 Ensembl ENCODE dbSUPER 0.4 -10.4 -10374 3.6 NCOA3 CTCF MAX RAD21 YY1 ZFHX2 CTBP1 GATA3 HNF4G TCF7L2 RNU6-145P ENSG00000233860 NAAA CXCL9 MIR4450 GC04M076533 SHROOM3
GH04I076545 Enhancer 0.8 Ensembl ENCODE 0.3 -26.5 -26507 2.4 SRF PKNOX1 ZNF189 JUN ZNF335 POLR2A FOXP2 FOS HNF4A SHROOM3 RNU6-1000P FAM47E STBD1 GC04M076533 RNU6-145P MIR4450
GH04I076566 Enhancer 0.4 dbSUPER 0.4 -6.7 -6650 1 RFX1 ATF7 ATF2 RNU6-145P ENSG00000233860 MIR4450 GC04M076533 SHROOM3
GH04I076558 Enhancer 0.4 ENCODE 0.4 -14.6 -14585 0.2 POLR2A POU5F1 RNU6-145P SHROOM3 MIR4450 GC04M076533
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR4450 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4450 Gene

Genomic Locations for MIR4450 Gene
chr4:76,573,568-76,573,632
(GRCh38/hg38)
Size:
65 bases
Orientation:
Plus strand
chr4:77,494,721-77,494,785
(GRCh37/hg19)

Genomic View for MIR4450 Gene

Genes around MIR4450 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4450 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4450 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4450 Gene

Proteins for MIR4450 Gene

Post-translational modifications for MIR4450 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4450 Gene

Domains & Families for MIR4450 Gene

Gene Families for MIR4450 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4450: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4450 Gene

Function for MIR4450 Gene

Phenotypes From GWAS Catalog for MIR4450 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4450 Gene

Localization for MIR4450 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4450 Gene

Pathways & Interactions for MIR4450 Gene

SuperPathways for MIR4450 Gene

No Data Available

Interacting Proteins for MIR4450 Gene

Gene Ontology (GO) - Biological Process for MIR4450 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4450 Gene

Drugs & Compounds for MIR4450 Gene

No Compound Related Data Available

Transcripts for MIR4450 Gene

mRNA/cDNA for MIR4450 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4450 Gene

No ASD Table

Relevant External Links for MIR4450 Gene

GeneLoc Exon Structure for
MIR4450
ECgene alternative splicing isoforms for
MIR4450

Expression for MIR4450 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4450 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4450 Gene:

MIR4450
genes like me logo Genes that share expression patterns with MIR4450: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4450 Gene

Orthologs for MIR4450 Gene

Evolution for MIR4450 Gene

ENSEMBL:
Gene Tree for MIR4450 (if available)
TreeFam:
Gene Tree for MIR4450 (if available)

No data available for Orthologs for MIR4450 Gene

Paralogs for MIR4450 Gene

No data available for Paralogs for MIR4450 Gene

Variants for MIR4450 Gene

Sequence variations from dbSNP and Humsavar for MIR4450 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1001554848 -- 76,571,664(+) C/A upstream_transcript_variant
rs1002335995 -- 76,572,416(+) G/A upstream_transcript_variant
rs1002860707 -- 76,572,805(+) G/A upstream_transcript_variant
rs1005592619 -- 76,571,654(+) C/ upstream_transcript_variant
rs1005955521 -- 76,572,833(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4450 Gene

Variant ID Type Subtype PubMed ID
nsv594696 CNV gain 21841781
nsv7363 OTHER inversion 18451855

Additional Variant Information for MIR4450 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4450

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4450 Gene

Disorders for MIR4450 Gene

Additional Disease Information for MIR4450

No disorders were found for MIR4450 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4450 Gene

Publications for MIR4450 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 58
  2. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3 58
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR4450 Gene

Sources for MIR4450 Gene

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