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Aliases for MIR4449 Gene

Subcategory (RNA class) for MIR4449 Gene


Quality Score for this RNA gene is


Aliases for MIR4449 Gene

  • MicroRNA 4449 2 3 5
  • Hsa-Mir-4449 3

External Ids for MIR4449 Gene

Previous GeneCards Identifiers for MIR4449 Gene

  • GC04U901503
  • GC04P053586

Summaries for MIR4449 Gene

Entrez Gene Summary for MIR4449 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4449 Gene

MIR4449 (MicroRNA 4449) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4449 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4449 Gene

Genomics for MIR4449 Gene

Regulatory Elements for MIR4449 Gene

Promoters for MIR4449 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000168273 118 1601 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF207

Genomic Locations for MIR4449 Gene

Genomic Locations for MIR4449 Gene
66 bases
Plus strand

Genomic View for MIR4449 Gene

Genes around MIR4449 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4449 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4449 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4449 Gene

Proteins for MIR4449 Gene

Post-translational modifications for MIR4449 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4449 Gene

Domains & Families for MIR4449 Gene

Gene Families for MIR4449 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4449: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4449 Gene

Function for MIR4449 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4449 Gene

Localization for MIR4449 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4449 Gene

Pathways & Interactions for MIR4449 Gene

SuperPathways for MIR4449 Gene

No Data Available

Interacting Proteins for MIR4449 Gene

Gene Ontology (GO) - Biological Process for MIR4449 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR4449 Gene

Drugs & Compounds for MIR4449 Gene

No Compound Related Data Available

Transcripts for MIR4449 Gene

mRNA/cDNA for MIR4449 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4449 Gene

No ASD Table

Relevant External Links for MIR4449 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR4449 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4449 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4449 Gene:

genes like me logo Genes that share expression patterns with MIR4449: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4449 Gene

Orthologs for MIR4449 Gene

Evolution for MIR4449 Gene

Gene Tree for MIR4449 (if available)
Gene Tree for MIR4449 (if available)

No data available for Orthologs for MIR4449 Gene

Paralogs for MIR4449 Gene

No data available for Paralogs for MIR4449 Gene

Variants for MIR4449 Gene

Sequence variations from dbSNP and Humsavar for MIR4449 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000491116 -- 52,711,390(+) TTTAT(C/T)TTGGG upstream-variant-2KB
rs1000853794 -- 52,711,694(+) TGTTA(A/G)CAGAT downstream-variant-500B, upstream-variant-2KB
rs1001753509 -- 52,712,849(+) GCGGG(G/T)TTCGG nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB
rs1002209097 -- 52,713,132(+) GTGTT(C/T)CTAGT intron-variant, nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB
rs1002309542 -- 52,711,313(+) GCCAT(G/T)CTCAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4449 Gene

Variant ID Type Subtype PubMed ID
nsv594201 CNV loss 21841781
nsv524494 CNV loss 19592680

Relevant External Links for MIR4449 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4449 Gene

Disorders for MIR4449 Gene

Relevant External Links for MIR4449

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR4449 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4449 Gene

Publications for MIR4449 Gene

  1. Identification of a novel microRNA, miR-4449, as a potential blood based marker in multiple myeloma. (PMID: 27155004) Shen X … Ju S (Clinical chemistry and laboratory medicine 2017) 3 60
  2. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3 60
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 60

Products for MIR4449 Gene

Sources for MIR4449 Gene

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