Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR4448 Gene

Subcategory (RNA class) for MIR4448 Gene


Quality Score for this RNA gene is


Aliases for MIR4448 Gene

  • MicroRNA 4448 2 3 5
  • Hsa-Mir-4448 3

External Ids for MIR4448 Gene

Previous GeneCards Identifiers for MIR4448 Gene

  • GC03U901791
  • GC03P183609

Summaries for MIR4448 Gene

Entrez Gene Summary for MIR4448 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4448 Gene

MIR4448 (MicroRNA 4448) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Parkinsons Disease Pathway.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4448 Gene

Genomics for MIR4448 Gene

Regulatory Elements for MIR4448 Gene

Enhancers for MIR4448 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F183904 0.6 ENCODE 0.3 +17.8 17798 0.1 CTCF ZNF366 ZNF512 SMC3 REST RAD21 THAP11 CYP2AB1P MIR4448
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR4448 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4448 Gene

183,886,800 bp from pter
183,886,885 bp from pter
86 bases
Plus strand

Genomic View for MIR4448 Gene

Genes around MIR4448 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4448 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4448 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4448 Gene

Proteins for MIR4448 Gene

Post-translational modifications for MIR4448 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4448 Gene

Domains & Families for MIR4448 Gene

Gene Families for MIR4448 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4448: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4448 Gene

Function for MIR4448 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4448 Gene

Localization for MIR4448 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4448 Gene

Pathways & Interactions for MIR4448 Gene

SuperPathways for MIR4448 Gene

SuperPathway Contained pathways
1 Parkinsons Disease Pathway
genes like me logo Genes that share pathways with MIR4448: view

Pathways by source for MIR4448 Gene

1 BioSystems pathway for MIR4448 Gene

Interacting Proteins for MIR4448 Gene

Gene Ontology (GO) - Biological Process for MIR4448 Gene


No data available for SIGNOR curated interactions for MIR4448 Gene

Transcripts for MIR4448 Gene

mRNA/cDNA for MIR4448 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4448 Gene

No ASD Table

Relevant External Links for MIR4448 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR4448 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4448 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4448 Gene:

genes like me logo Genes that share expression patterns with MIR4448: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4448 Gene

Orthologs for MIR4448 Gene

Evolution for MIR4448 Gene

Gene Tree for MIR4448 (if available)
Gene Tree for MIR4448 (if available)

No data available for Orthologs for MIR4448 Gene

Paralogs for MIR4448 Gene

No data available for Paralogs for MIR4448 Gene

Variants for MIR4448 Gene

Sequence variations from dbSNP and Humsavar for MIR4448 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs115734076 -- 183,886,033(+) ACCGT(C/T)CTCAC upstream-variant-2KB
rs11713034 -- 183,886,155(+) CATAC(C/T)GCTTT upstream-variant-2KB
rs11926967 -- 183,887,218(+) ctcct(C/T)tctct downstream-variant-500B
rs11926985 -- 183,887,061(+) taacc(A/G)tctcc downstream-variant-500B
rs13100438 -- 183,887,048(+) ttatc(C/T)ggagg downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR4448 Gene

Variant ID Type Subtype PubMed ID
esv3598933 CNV gain 21293372
nsv592656 CNV gain 21841781
nsv979908 CNV duplication 23825009

Relevant External Links for MIR4448 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4448 Gene

Disorders for MIR4448 Gene

No disorders were found for MIR4448 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for MIR4448 Gene

Publications for MIR4448 Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima D.D. … Dave S.S. (Blood 2010) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4448 Gene

Sources for MIR4448 Gene

Loading form....