Aliases for MIR4448 Gene
Subcategory (RNA class) for MIR4448 Gene
Quality Score for this RNA gene is
External Ids for MIR4448 Gene
- HGNC: 41604
- Entrez Gene: 100616127
- Ensembl: ENSG00000263932
- miRBase: hsa-mir-4448
Previous GeneCards Identifiers for MIR4448 Gene
- GC03U901791
- GC03P183609
Summaries for MIR4448 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR4448 Gene
MIR4448 (MicroRNA 4448) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Parkinsons Disease Pathway.
Additional gene information for MIR4448 Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4448 Gene
Genomics for MIR4448 Gene
GeneHancer (GH) Regulatory Elements for MIR4448 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH03I183904 | Enhancer | 0.6 | ENCODE | 0.4 | +17.8 | 17798 | 0.1 | CTCF USF1 REST RAD21 ARID2 ADNP SMC3 ZNF143 ZNF24 THAP11 | CYP2AB1P MIR4448 |
Regulatory Element Products
Genomic Locations for MIR4448 Gene
- chr3:183,886,800-183,886,885
- (GRCh38/hg38)
- Size:
- 86 bases
- Orientation:
- Plus strand
- chr3:183,604,588-183,604,673
- (GRCh37/hg19)
Genomic View for MIR4448 Gene
- Cytogenetic band:
-
- 3q27.1 by Ensembl
- 3q27.1 by Entrez Gene
- 3q27.1 by HGNC


RefSeq DNA sequence for MIR4448 Gene
Proteins for MIR4448 Gene
Post-translational modifications for MIR4448 Gene
Antibody Products
- Search GeneTex for Antibodies for MIR4448
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR4448
- Origene Custom Protein Services for MIR4448
- Search GeneTex for Proteins for MIR4448
No data available for DME Specific Peptides for MIR4448 Gene
Domains & Families for MIR4448 Gene
Gene Families for MIR4448 Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4448 Gene
Function for MIR4448 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR4448
-
- Search ViGene Biosciences for MIR4448
CRISPR Products
- Browse CRISPR knockouts for MIR4448
- Applied Biological Materials CRISPR for MIR4448
-
Vectors and viruses for KO, Activation, Repression, and more
Inhibitory RNA Products
- Search ViGene Biosciences for MIR4448
Clone Products
- GenScript: Custom all cDNA clones Services for MIR4448
- VectorBuilder custom plasmid, inducible vectors for MIR4448
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR4448
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR4448
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4448 Gene
Localization for MIR4448 Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4448 Gene
Pathways & Interactions for MIR4448 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Parkinsons Disease Pathway |
Pathways by source for MIR4448 Gene
1 BioSystems pathway for MIR4448 Gene
Interacting Proteins for MIR4448 Gene
No data available for SIGNOR curated interactions for MIR4448 Gene
Transcripts for MIR4448 Gene
mRNA/cDNA for MIR4448 Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for MIR4448
- Applied Biological Materials CRISPR for MIR4448
-
Vectors and viruses for KO, Activation, Repression, and more
Inhibitory RNA Products
- Search ViGene Biosciences for MIR4448
Clone Products
- GenScript: Custom all cDNA clones Services for MIR4448
- VectorBuilder custom plasmid, inducible vectors for MIR4448
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR4448
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR4448
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MIR4448 Gene
NURSA nuclear receptor signaling pathways regulating expression of MIR4448 Gene:
MIR4448Primer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4448 Gene
Orthologs for MIR4448 Gene
No data available for Orthologs for MIR4448 Gene
Paralogs for MIR4448 Gene
No data available for Paralogs for MIR4448 Gene
Variants for MIR4448 Gene
SNP ID | Clin | Chr 03 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1001314745 | -- | 183,885,012(+) | C/G | upstream_transcript_variant | |
rs1002204466 | -- | 183,887,280(+) | G/A | downstream_transcript_variant | |
rs1004174562 | -- | 183,885,885(+) | T/G | upstream_transcript_variant | |
rs1004294070 | -- | 183,885,592(+) | G/T | upstream_transcript_variant | |
rs1005294465 | -- | 183,886,886(+) | G/A | downstream_transcript_variant |
Additional Variant Information for MIR4448 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR4448
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4448 Gene
Disorders for MIR4448 Gene
Additional Disease Information for MIR4448
No disorders were found for MIR4448 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4448 Gene
Publications for MIR4448 Gene
- Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3 58
- miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58
Products for MIR4448 Gene
- Browse R&D Systems for Antibodies
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- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- Browse cDNA Clones
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- Browse Small Molecules
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- Custom Antibody Services
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- GenScript: Custom all cDNA clones Services for MIR4448
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- Design optimal peptide antigens
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- Novus Biologicals
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- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR4448
- VectorBuilder custom plasmid, inducible vectors for MIR4448
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR4448
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for MIR4448
- Search GeneTex for Proteins for MIR4448
Sources for MIR4448 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew