Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR4446 Gene

Subcategory (RNA class) for MIR4446 Gene


Quality Score for this RNA gene is


Aliases for MIR4446 Gene

  • MicroRNA 4446 2 3 5
  • Hsa-Mir-4446 3
  • Mir-4446 3

External Ids for MIR4446 Gene

Previous GeneCards Identifiers for MIR4446 Gene

  • GC03U901796
  • GC03P113319

Summaries for MIR4446 Gene

Entrez Gene Summary for MIR4446 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4446 Gene

MIR4446 (MicroRNA 4446) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4446 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4446 Gene

Genomics for MIR4446 Gene

Genomic Locations for MIR4446 Gene

Genomic Locations for MIR4446 Gene
67 bases
Plus strand

Genomic View for MIR4446 Gene

Genes around MIR4446 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4446 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4446 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4446 Gene

No data available for Regulatory Elements for MIR4446 Gene

Proteins for MIR4446 Gene

Post-translational modifications for MIR4446 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4446 Gene

Domains & Families for MIR4446 Gene

Gene Families for MIR4446 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4446: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4446 Gene

Function for MIR4446 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4446 Gene

Localization for MIR4446 Gene

Gene Ontology (GO) - Cellular Components for MIR4446 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR4446: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR4446 Gene

Pathways & Interactions for MIR4446 Gene

SuperPathways for MIR4446 Gene

No Data Available

Interacting Proteins for MIR4446 Gene

Gene Ontology (GO) - Biological Process for MIR4446 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR4446 Gene

Drugs & Compounds for MIR4446 Gene

No Compound Related Data Available

Transcripts for MIR4446 Gene

mRNA/cDNA for MIR4446 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4446 Gene

No ASD Table

Relevant External Links for MIR4446 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR4446 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4446 Gene:

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4446 Gene

Orthologs for MIR4446 Gene

Evolution for MIR4446 Gene

Gene Tree for MIR4446 (if available)
Gene Tree for MIR4446 (if available)

No data available for Orthologs for MIR4446 Gene

Paralogs for MIR4446 Gene

No data available for Paralogs for MIR4446 Gene

Variants for MIR4446 Gene

Sequence variations from dbSNP and Humsavar for MIR4446 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000816829 -- 113,594,778(+) ACAAG(-/A)AAAAA intron-variant, upstream-variant-2KB
rs1002230289 -- 113,593,394(+) CCCTA(C/T)TGTGA intron-variant, upstream-variant-2KB
rs1004424963 -- 113,593,514(+) AATAT(C/T)GGTGC intron-variant, upstream-variant-2KB
rs1004494265 -- 113,595,434(+) AATTA(G/T)GTGGG intron-variant, downstream-variant-500B
rs1006523258 -- 113,593,143(+) CAATT(A/T)ACAAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4446 Gene

Variant ID Type Subtype PubMed ID
nsv1013506 CNV gain 25217958

Relevant External Links for MIR4446 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4446 Gene

Disorders for MIR4446 Gene

Relevant External Links for MIR4446

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR4446 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4446 Gene

Publications for MIR4446 Gene

  1. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 60
  2. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles RA … Easton DF (Nature genetics 2013) 3 60
  3. Transcription factors are targeted by differentially expressed miRNAs in primates. (PMID: 22454130) Dannemann M … Kelso J (Genome biology and evolution 2012) 3 60
  4. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 60
  5. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3 60

Products for MIR4446 Gene

Sources for MIR4446 Gene

Loading form....