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Aliases for MIR4444-1 Gene

Subcategory (RNA class) for MIR4444-1 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4444-1 Gene

  • MicroRNA 4444-1 2 3
  • MicroRNA 4444 2 3
  • HNRNPA3 4 5
  • Heterogeneous Nuclear Ribonucleoprotein A3 5
  • Hsa-Mir-4444-1 3
  • Hsa-Mir-4444 3
  • HnRNP A3 4
  • MIR4444 3
  • HNRPA3 4

External Ids for MIR4444-1 Gene

Previous HGNC Symbols for MIR4444-1 Gene

  • MIR4444

Previous GeneCards Identifiers for MIR4444-1 Gene

  • GC02U902482
  • GC02P178078
  • GC02P178080

Summaries for MIR4444-1 Gene

Entrez Gene Summary for MIR4444-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4444-1 Gene

MIR4444-1 (MicroRNA 4444-1) is an RNA Gene, and is affiliated with the miRNA class. An important paralog of this gene is HNRNPA1.

UniProtKB/Swiss-Prot for MIR4444-1 Gene

  • Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4444-1 Gene

Genomics for MIR4444-1 Gene

Regulatory Elements for MIR4444-1 Gene


Promoters for MIR4444-1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MIR4444-1 Gene

Chromosome:
2
Start:
177,212,563 bp from pter
End:
177,223,958 bp from pter
Size:
11,396 bases
Orientation:
Plus strand

Genomic View for MIR4444-1 Gene

Genes around MIR4444-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4444-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4444-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4444-1 Gene

Proteins for MIR4444-1 Gene

  • Protein details for MIR4444-1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51991-ROA3_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein A3
    Protein Accession:
    P51991
    Secondary Accessions:
    • D3DPF4
    • Q53RW7
    • Q6URK5

    Protein attributes for MIR4444-1 Gene

    Size:
    378 amino acids
    Molecular mass:
    39595 Da
    Quaternary structure:
    • Identified in the spliceosome C complex.
    • Identified in the spliceosome C complex.

    Alternative splice isoforms for MIR4444-1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR4444-1 Gene

Post-translational modifications for MIR4444-1 Gene

  • Ubiquitination at Lys 4, Lys 36, Lys 57, Lys 73, and Lys 151
  • Modification sites at PhosphoSitePlus

Other Protein References for MIR4444-1 Gene

No data available for DME Specific Peptides for MIR4444-1 Gene

Domains & Families for MIR4444-1 Gene

Gene Families for MIR4444-1 Gene

Protein Domains for MIR4444-1 Gene

Graphical View of Domain Structure for InterPro Entry

P51991

UniProtKB/Swiss-Prot:

ROA3_HUMAN :
  • Contains 2 RRM (RNA recognition motif) domains.
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with MIR4444-1: view

No data available for Suggested Antigen Peptide Sequences for MIR4444-1 Gene

Function for MIR4444-1 Gene

Molecular function for MIR4444-1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing.

Gene Ontology (GO) - Molecular Function for MIR4444-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS --
GO:0003729 mRNA binding IEA --
GO:0005515 protein binding IPI --
GO:0044822 poly(A) RNA binding IDA --
GO:0051033 RNA transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with MIR4444-1: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4444-1 Gene

Localization for MIR4444-1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR4444-1 Gene

Nucleus. Note=Component of ribonucleosomes.

Gene Ontology (GO) - Cellular Components for MIR4444-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0030529 intracellular ribonucleoprotein complex TAS --
GO:0035770 ribonucleoprotein granule IEA --
genes like me logo Genes that share ontologies with MIR4444-1: view

No data available for Subcellular locations from COMPARTMENTS for MIR4444-1 Gene

Pathways & Interactions for MIR4444-1 Gene

SuperPathways for MIR4444-1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4444-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0010467 gene expression TAS --
GO:0051028 mRNA transport IEA --
genes like me logo Genes that share ontologies with MIR4444-1: view

No data available for Pathways by source and SIGNOR curated interactions for MIR4444-1 Gene

Drugs & Compounds for MIR4444-1 Gene

No Compound Related Data Available

Transcripts for MIR4444-1 Gene

mRNA/cDNA for MIR4444-1 Gene

(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4444-1 Gene

No ASD Table

Relevant External Links for MIR4444-1 Gene

GeneLoc Exon Structure for
MIR4444-1
ECgene alternative splicing isoforms for
MIR4444-1

Expression for MIR4444-1 Gene

mRNA expression in normal human tissues for MIR4444-1 Gene

genes like me logo Genes that share expression patterns with MIR4444-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4444-1 Gene

Orthologs for MIR4444-1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR4444-1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 35
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia HNRNPA3 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HNRNPA3 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm6793 35
  • 99 (a)
OneToMany
Gm8991 35
  • 97 (a)
OneToMany
Gm9242 35
  • 99 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia HNRNPA3 35
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 84 (a)
OneToMany
chicken
(Gallus gallus)
Aves HNRNPA3 35
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HNRNPA3 35
  • 86 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii hnrnpa3 35
  • 83 (a)
OneToOne
Species where no ortholog for MIR4444-1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR4444-1 Gene

ENSEMBL:
Gene Tree for MIR4444-1 (if available)
TreeFam:
Gene Tree for MIR4444-1 (if available)

Paralogs for MIR4444-1 Gene

genes like me logo Genes that share paralogs with MIR4444-1: view

Variants for MIR4444-1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4444-1 Gene

Variant ID Type Subtype PubMed ID
esv2422240 CNV deletion 17116639
esv2422315 CNV deletion 17116639
esv3893725 CNV gain 25118596
nsv1002218 CNV loss 25217958
nsv460704 CNV gain 19166990
nsv590641 CNV gain 21841781
nsv834465 CNV loss 17160897
nsv834736 CNV gain 17160897
nsv963330 CNV duplication 23825009

Relevant External Links for MIR4444-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4444-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR4444-1 Gene

Disorders for MIR4444-1 Gene

Relevant External Links for MIR4444-1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4444-1

No disorders were found for MIR4444-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4444-1 Gene

Publications for MIR4444-1 Gene

  1. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 65
  2. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 65
  3. Uncovering global SUMOylation signaling networks in a site-specific manner. (PMID: 25218447) Hendriks I.A. … Vertegaal A.C. (Nat. Struct. Mol. Biol. 2014) 4 65
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 65
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 65

Products for MIR4444-1 Gene

Sources for MIR4444-1 Gene

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