Subcategory (RNA class) for MIR4444-1 Gene
Quality Score for this RNA gene is
Aliases for MIR4444-1 Gene
External Ids for MIR4444-1 Gene
Previous HGNC Symbols for MIR4444-1 Gene
Previous GeneCards Identifiers for MIR4444-1 Gene
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR4444-1 Gene
MIR4444-1 (MicroRNA 4444-1) is an RNA Gene, and is affiliated with the miRNA class. An important paralog of this gene is HNRNPA1.
UniProtKB/Swiss-Prot for MIR4444-1 Gene
Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing.