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Aliases for MIR4444-1 Gene

Subcategory (RNA class) for MIR4444-1 Gene


Quality Score for this RNA gene is


Aliases for MIR4444-1 Gene

  • MicroRNA 4444-1 2 3
  • MicroRNA 4444 2 3
  • HNRNPA3 4 5
  • Heterogeneous Nuclear Ribonucleoprotein A3 5
  • Hsa-Mir-4444-1 3
  • Hsa-Mir-4444 3
  • HnRNP A3 4
  • MIR4444 3
  • HNRPA3 4

External Ids for MIR4444-1 Gene

Previous HGNC Symbols for MIR4444-1 Gene

  • MIR4444

Previous GeneCards Identifiers for MIR4444-1 Gene

  • GC02U902482
  • GC02P178078
  • GC02P178080

Summaries for MIR4444-1 Gene

Entrez Gene Summary for MIR4444-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4444-1 Gene

MIR4444-1 (MicroRNA 4444-1) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. An important paralog of this gene is HNRNPA1.

UniProtKB/Swiss-Prot for MIR4444-1 Gene

  • Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4444-1 Gene

Genomics for MIR4444-1 Gene

Regulatory Elements for MIR4444-1 Gene

Enhancers for MIR4444-1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F177237 1.8 FANTOM5 Ensembl ENCODE 13.5 +30.3 30338 10.6 MLX CREB3L1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFE2L2 HNRNPA3 ENSG00000222043 ENSG00000229337 MIR4444-1 ENSG00000238295 ENSG00000237178 LOC100130691 LOC105373754 DNAJC19P5
GH02F177187 1.3 Ensembl ENCODE 12.5 -24.2 -24201 2.0 ATF1 MLX ZNF133 ARID4B FEZF1 DMAP1 ZNF48 YY1 SLC30A9 PAF1 ENSG00000229337 MIR4444-1 HNRNPA3 LOC100130691 LOC105373754 GC02P177196 LOC391465
GH02F177235 0.7 ENCODE 13.6 +23.6 23638 2.1 L3MBTL2 CEBPG ZNF121 FOSL1 ZNF316 SSRP1 JUND RAD51 ATF3 NFE2 ENSG00000229337 MIR4444-1 HNRNPA3 ENSG00000222043 NFE2L2 LOC100130691 LOC105373754 DNAJC19P5 MIR3128
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4444-1 on UCSC Golden Path with GeneCards custom track

Promoters for MIR4444-1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MIR4444-1 Gene

177,212,563 bp from pter
177,223,958 bp from pter
11,396 bases
Plus strand

Genomic View for MIR4444-1 Gene

Genes around MIR4444-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4444-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4444-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4444-1 Gene

Proteins for MIR4444-1 Gene

  • Protein details for MIR4444-1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein A3
    Protein Accession:
    Secondary Accessions:
    • D3DPF4
    • Q53RW7
    • Q6URK5

    Protein attributes for MIR4444-1 Gene

    378 amino acids
    Molecular mass:
    39595 Da
    Quaternary structure:
    • Identified in the spliceosome C complex.
    • Identified in the spliceosome C complex.

    Alternative splice isoforms for MIR4444-1 Gene


neXtProt entry for MIR4444-1 Gene

Post-translational modifications for MIR4444-1 Gene

  • Ubiquitination at Lys 4, Lys 36, Lys 57, Lys 73, and Lys 151
  • Modification sites at PhosphoSitePlus

Other Protein References for MIR4444-1 Gene

No data available for DME Specific Peptides for MIR4444-1 Gene

Domains & Families for MIR4444-1 Gene

Gene Families for MIR4444-1 Gene

Protein Domains for MIR4444-1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 RRM (RNA recognition motif) domains.
  • Contains 2 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with MIR4444-1: view

No data available for Suggested Antigen Peptide Sequences for MIR4444-1 Gene

Function for MIR4444-1 Gene

Molecular function for MIR4444-1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing.

Gene Ontology (GO) - Molecular Function for MIR4444-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding TAS --
GO:0005515 protein binding IPI --
GO:0044822 poly(A) RNA binding IDA --
genes like me logo Genes that share ontologies with MIR4444-1: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4444-1 Gene

Localization for MIR4444-1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR4444-1 Gene

Nucleus. Note=Component of ribonucleosomes.

Gene Ontology (GO) - Cellular Components for MIR4444-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IEA --
GO:0019013 viral nucleocapsid IEA --
GO:0030529 intracellular ribonucleoprotein complex TAS --
genes like me logo Genes that share ontologies with MIR4444-1: view

No data available for Subcellular locations from COMPARTMENTS for MIR4444-1 Gene

Pathways & Interactions for MIR4444-1 Gene

genes like me logo Genes that share pathways with MIR4444-1: view

Pathways by source for MIR4444-1 Gene

Gene Ontology (GO) - Biological Process for MIR4444-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with MIR4444-1: view

No data available for SIGNOR curated interactions for MIR4444-1 Gene

Transcripts for MIR4444-1 Gene

mRNA/cDNA for MIR4444-1 Gene

(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4444-1 Gene

No ASD Table

Relevant External Links for MIR4444-1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR4444-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4444-1 Gene

genes like me logo Genes that share expression patterns with MIR4444-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4444-1 Gene

Orthologs for MIR4444-1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR4444-1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia HNRNPA3 35
  • 100 (a)
(Bos Taurus)
Mammalia -- 35
  • 99 (a)
(Mus musculus)
Mammalia Gm6793 35
  • 99 (a)
Gm9242 35
  • 99 (a)
Gm8991 35
  • 97 (a)
(Monodelphis domestica)
Mammalia HNRNPA3 35
  • 90 (a)
(Pan troglodytes)
Mammalia -- 35
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia HNRNPA3 35
  • 71 (a)
(Gallus gallus)
Aves HNRNPA3 35
  • 89 (a)
(Anolis carolinensis)
Reptilia HNRNPA3 35
  • 86 (a)
(Danio rerio)
Actinopterygii hnrnpa3 35
  • 83 (a)
Species where no ortholog for MIR4444-1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR4444-1 Gene

Gene Tree for MIR4444-1 (if available)
Gene Tree for MIR4444-1 (if available)

Paralogs for MIR4444-1 Gene

Variants for MIR4444-1 Gene

Sequence variations from dbSNP and Humsavar for MIR4444-1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs114151293 -- 177,212,453(+) TCTCT(C/G)GTGAC intron-variant, upstream-variant-2KB
rs114658722 -- 177,211,924(+) ACAAT(C/T)ATTCG nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs114778780 -- 177,212,557(+) AAGGC(C/G)CTCTT intron-variant, nc-transcript-variant, upstream-variant-2KB
rs116656004 -- 177,211,545(+) TTTAC(A/G)CTCCC nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs117475092 -- 177,211,926(+) AATCA(C/T)TCGCA nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MIR4444-1 Gene

Variant ID Type Subtype PubMed ID
nsv963330 CNV duplication 23825009
nsv834736 CNV gain 17160897
nsv834465 CNV loss 17160897
nsv590641 CNV gain 21841781
nsv460704 CNV gain 19166990
nsv1002218 CNV loss 25217958
esv3893725 CNV gain 25118596
esv2422315 CNV deletion 17116639
esv2422240 CNV deletion 17116639

Relevant External Links for MIR4444-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4444-1 Gene

Disorders for MIR4444-1 Gene

Relevant External Links for MIR4444-1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR4444-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4444-1 Gene

Publications for MIR4444-1 Gene

  1. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64
  2. Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. (PMID: 24129315) Guo A. … Comb M.J. (Mol. Cell. Proteomics 2014) 4 64
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  4. Uncovering global SUMOylation signaling networks in a site-specific manner. (PMID: 25218447) Hendriks I.A. … Vertegaal A.C. (Nat. Struct. Mol. Biol. 2014) 4 64
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64

Products for MIR4444-1 Gene

Sources for MIR4444-1 Gene

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