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Aliases for MIR4442 Gene

Subcategory (RNA class) for MIR4442 Gene


Quality Score for this RNA gene is


Aliases for MIR4442 Gene

  • MicroRNA 4442 2 3
  • EC 4 61
  • TOP2B 4 5
  • DNA Topoisomerase II, Beta Isozyme 4
  • Topoisomerase (DNA) II Beta 5
  • Hsa-Mir-4442 3
  • Mir-4442 3

External Ids for MIR4442 Gene

Previous GeneCards Identifiers for MIR4442 Gene

  • GC03U901802
  • GC03M025707

Summaries for MIR4442 Gene

Entrez Gene Summary for MIR4442 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4442 Gene

MIR4442 (MicroRNA 4442) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Metabolism of proteins and SUMOylation. An important paralog of this gene is TOP2A.

UniProtKB/Swiss-Prot for MIR4442 Gene

  • Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4442 Gene

Genomics for MIR4442 Gene

Regulatory Elements for MIR4442 Gene

Enhancers for MIR4442 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F025662 0.4 ENCODE 0.8 +0.5 507 4.6 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A YY1 ZNF143 FOS ZNF263 TOP2B MIR4442 GC03M025633
GH03F025653 0.4 Ensembl 0.4 +9.5 9539 4.4 PKNOX1 ZFP3 SCRT2 CEBPB FEZF1 EBF1 OXSM NGLY1 TOP2B MIR4442 GC03M025633
GH03F025647 1.1 Ensembl ENCODE 0.3 +16.6 16629 1.0 YBX3 CTCF CBX3 TAL1 ARID4B MAX ZNF2 RAD21 RFX5 POLR2A GC03M025633 TOP2B MIR4442
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR4442 on UCSC Golden Path with GeneCards custom track

Promoters for MIR4442 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001359668 1039 3801 PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 YY1 ZNF143 FOS ZNF263

Genomic Location for MIR4442 Gene

25,597,905 bp from pter
25,664,939 bp from pter
67,035 bases
Minus strand

Genomic View for MIR4442 Gene

Genes around MIR4442 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4442 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4442 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4442 Gene

Proteins for MIR4442 Gene

  • Protein details for MIR4442 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DNA topoisomerase 2-beta
    Protein Accession:
    Secondary Accessions:
    • Q13600
    • Q9UMG8
    • Q9UQP8

    Protein attributes for MIR4442 Gene

    1626 amino acids
    Molecular mass:
    183267 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Homodimer.
    • Homodimer.
    • Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils.

    Three dimensional structures from OCA and Proteopedia for MIR4442 Gene

    Alternative splice isoforms for MIR4442 Gene


neXtProt entry for MIR4442 Gene

Post-translational modifications for MIR4442 Gene

  • Ubiquitination at Lys 144, Lys 212, Lys 254, Lys 342, Lys 407, Lys 412, Lys 541, Lys 550, Lys 605, Lys 635, Lys 643, Lys 712, Lys 744, and Lys 1008
  • Modification sites at PhosphoSitePlus

Other Protein References for MIR4442 Gene

Domains & Families for MIR4442 Gene

Gene Families for MIR4442 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Toprim domain.
  • Belongs to the type II topoisomerase family.
  • Contains 1 Toprim domain.
  • Belongs to the type II topoisomerase family.
genes like me logo Genes that share domains with MIR4442: view

No data available for Suggested Antigen Peptide Sequences for MIR4442 Gene

Function for MIR4442 Gene

Molecular function for MIR4442 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
UniProtKB/Swiss-Prot Function:
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.

Enzyme Numbers (IUBMB) for MIR4442 Gene

Gene Ontology (GO) - Molecular Function for MIR4442 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IDA --
GO:0003916 DNA topoisomerase activity IEA --
GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity IDA --
GO:0005080 protein kinase C binding IPI --
genes like me logo Genes that share ontologies with MIR4442: view

Animal Model Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4442 Gene

Localization for MIR4442 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR4442 Gene

Cytoplasm. Nucleus, nucleolus.

Gene Ontology (GO) - Cellular Components for MIR4442 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000792 heterochromatin IDA --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with MIR4442: view

No data available for Subcellular locations from COMPARTMENTS for MIR4442 Gene

Pathways & Interactions for MIR4442 Gene

genes like me logo Genes that share pathways with MIR4442: view

Gene Ontology (GO) - Biological Process for MIR4442 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000712 resolution of meiotic recombination intermediates IBA --
GO:0000819 sister chromatid segregation IBA --
GO:0001764 neuron migration IEA --
GO:0006259 DNA metabolic process IEA --
GO:0006265 DNA topological change IDA --
genes like me logo Genes that share ontologies with MIR4442: view

No data available for SIGNOR curated interactions for MIR4442 Gene

Transcripts for MIR4442 Gene

mRNA/cDNA for MIR4442 Gene

(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4442 Gene

No ASD Table

Relevant External Links for MIR4442 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR4442 Gene

mRNA expression in normal human tissues for MIR4442 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4442 Gene:

genes like me logo Genes that share expression patterns with MIR4442: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4442 Gene

Orthologs for MIR4442 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MIR4442 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TOP2B 35
  • 100 (a)
(Canis familiaris)
Mammalia TOP2B 35
  • 98 (a)
(Bos Taurus)
Mammalia TOP2B 35
  • 97 (a)
(Mus musculus)
Mammalia Top2b 35
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia TOP2B 35
  • 94 (a)
(Monodelphis domestica)
Mammalia TOP2B 35
  • 92 (a)
(Gallus gallus)
Aves TOP2B 35
  • 88 (a)
(Anolis carolinensis)
Reptilia TOP2B 35
  • 87 (a)
(Danio rerio)
Actinopterygii top2b 35
  • 72 (a)
fruit fly
(Drosophila melanogaster)
Insecta Top2 35
  • 55 (a)
(Caenorhabditis elegans)
Secernentea cin-4 35
  • 51 (a)
top-2 35
  • 50 (a)
Y46H3C.4 35
  • 43 (a)
R05D3.12 35
  • 41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TOP2 35 37
  • 43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 63 (a)
Species where no ortholog for MIR4442 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR4442 Gene

Gene Tree for MIR4442 (if available)
Gene Tree for MIR4442 (if available)

Paralogs for MIR4442 Gene

Paralogs for MIR4442 Gene

genes like me logo Genes that share paralogs with MIR4442: view

Variants for MIR4442 Gene

Sequence variations from dbSNP and Humsavar for MIR4442 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10433573 -- 25,664,786(+) AAGGC(A/C)GCCTT nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime
rs112577513 -- 25,666,596(+) CTTCC(A/G)TTTTT upstream-variant-2KB
rs113200659 -- 25,666,717(+) TCAGC(C/T)TCCCA upstream-variant-2KB
rs113494951 -- 25,665,146(+) GCAGG(A/G)GCTGC upstream-variant-2KB
rs114485572 -- 25,665,448(+) GACGC(C/T)GCTGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4442 Gene

Variant ID Type Subtype PubMed ID
esv3893676 CNV loss 25118596

Relevant External Links for MIR4442 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4442 Gene

Disorders for MIR4442 Gene

Relevant External Links for MIR4442

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR4442 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4442 Gene

Publications for MIR4442 Gene

  1. System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. (PMID: 25755297) Xiao Z. … Vertegaal A.C. (Mol. Cell. Proteomics 2015) 4 64
  2. SUMO-2 orchestrates chromatin modifiers in response to DNA damage. (PMID: 25772364) Hendriks I.A. … Vertegaal A.C. (Cell Rep. 2015) 4 64
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  4. Uncovering global SUMOylation signaling networks in a site-specific manner. (PMID: 25218447) Hendriks I.A. … Vertegaal A.C. (Nat. Struct. Mol. Biol. 2014) 4 64
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64

Products for MIR4442 Gene

Sources for MIR4442 Gene

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