Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR4437 Gene

Subcategory (RNA class) for MIR4437 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR4437 Gene

  • MicroRNA 4437 2 3 5
  • Hsa-Mir-4437 3
  • Mir-4437 3

External Ids for MIR4437 Gene

Previous GeneCards Identifiers for MIR4437 Gene

  • GC02U902411
  • GC02M182172

Summaries for MIR4437 Gene

Entrez Gene Summary for MIR4437 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4437 Gene

MIR4437 (MicroRNA 4437) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4437 Gene

Genomics for MIR4437 Gene

Regulatory Elements for MIR4437 Gene

Enhancers for MIR4437 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F181303 1.4 FANTOM5 ENCODE 0.8 -4.0 -4015 11.6 PKNOX1 ATF1 MLX WRNIP1 ARID4B DMAP1 CBX5 SP5 JUNB MIER2 ITGA4 UBE2E3 MIR4437 GC02P181326
GH02F181300 0.8 Ensembl ENCODE 0.8 +4.7 4724 1.3 ZNF146 HLF CEBPA MAX CEBPB CEBPG MYC UBE2E3 MIR4437 ENSG00000238171
GH02F181275 0.7 Ensembl ENCODE 0.3 +29.8 29823 1.0 CTCF MTA2 THRB ITGA4 UBE2E3 MIR4437 ENSG00000238171
GH02F181252 0.9 FANTOM5 Ensembl ENCODE 0.2 +52.9 52856 1.2 HLF ITGA4 MIR4437 ENSG00000238171
GH02F181123 1.1 Ensembl ENCODE 0.1 +179.5 179465 5.4 PKNOX1 ATF1 MXI1 TBL1XR1 BMI1 RELA CBX5 EED ETV6 CREM ITGA4 UBE2E3 ENSG00000238171 MIR4437
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4437 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4437 Gene

Chromosome:
2
Start:
181,305,593 bp from pter
End:
181,305,652 bp from pter
Size:
60 bases
Orientation:
Minus strand

Genomic View for MIR4437 Gene

Genes around MIR4437 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4437 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4437 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4437 Gene

ORGUL Member Location for MIR4437 Gene

ORGUL Member Location for MIR4437 gene

Proteins for MIR4437 Gene

Post-translational modifications for MIR4437 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4437 Gene

Domains & Families for MIR4437 Gene

Gene Families for MIR4437 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4437: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4437 Gene

Function for MIR4437 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4437 Gene

Localization for MIR4437 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4437 Gene

Pathways & Interactions for MIR4437 Gene

SuperPathways for MIR4437 Gene

No Data Available

Interacting Proteins for MIR4437 Gene

Gene Ontology (GO) - Biological Process for MIR4437 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4437 Gene

Transcripts for MIR4437 Gene

mRNA/cDNA for MIR4437 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4437 Gene

No ASD Table

Relevant External Links for MIR4437 Gene

GeneLoc Exon Structure for
MIR4437
ECgene alternative splicing isoforms for
MIR4437

Expression for MIR4437 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4437 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4437 Gene:

MIR4437
genes like me logo Genes that share expression patterns with MIR4437: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4437 Gene

Orthologs for MIR4437 Gene

Evolution for MIR4437 Gene

ENSEMBL:
Gene Tree for MIR4437 (if available)
TreeFam:
Gene Tree for MIR4437 (if available)

No data available for Orthologs for MIR4437 Gene

Paralogs for MIR4437 Gene

No data available for Paralogs for MIR4437 Gene

Variants for MIR4437 Gene

Sequence variations from dbSNP and Humsavar for MIR4437 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs112590530 -- 181,305,670(+) ACCTC(C/T)GAGTC intron-variant, upstream-variant-2KB
rs138113541 -- 181,305,462(+) GAGGC(A/G)TAGAA intron-variant, downstream-variant-500B
rs140564564 -- 181,306,605(+) TAAAG(A/G)ATGTA intron-variant, upstream-variant-2KB
rs141369189 -- 181,306,899(+) TAAAT(A/C)TTCTG intron-variant, upstream-variant-2KB
rs142012293 -- 181,305,902(+) AGGCT(-/G)GTTGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4437 Gene

Variant ID Type Subtype PubMed ID
nsv954441 CNV duplication 24416366
esv3893514 CNV gain 25118596
esv3584213 CNV loss 25503493

Relevant External Links for MIR4437 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4437

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4437 Gene

Disorders for MIR4437 Gene

Relevant External Links for MIR4437

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4437

No disorders were found for MIR4437 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4437 Gene

Publications for MIR4437 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  2. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima D.D. … Dave S.S. (Blood 2010) 3 64
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4437 Gene

Sources for MIR4437 Gene

Content
Loading form....