Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR4437 Gene

Subcategory (RNA class) for MIR4437 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR4437 Gene

  • MicroRNA 4437 2 3 5
  • Hsa-Mir-4437 3
  • Mir-4437 3

External Ids for MIR4437 Gene

Previous GeneCards Identifiers for MIR4437 Gene

  • GC02U902411
  • GC02M182172

Summaries for MIR4437 Gene

Entrez Gene Summary for MIR4437 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4437 Gene

MIR4437 (MicroRNA 4437) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4437 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4437 Gene

Genomics for MIR4437 Gene

GeneHancer (GH) Regulatory Elements for MIR4437 Gene

Promoters and enhancers for MIR4437 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I181303 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 0.8 -4.0 -4014 11.6 PKNOX1 FOXA2 MLX ARID4B DMAP1 ATF7 RUNX3 SP5 JUNB MIER2 ITGA4 UBE2E3 MIR4437 GC02P181326 LINC01934
GH02I181300 Enhancer 1 Ensembl ENCODE dbSUPER 0.8 +4.8 4755 1.3 ZNF146 HLF MAX CEBPB CEBPG POLR2A CEBPA RUNX3 MYC UBE2E3 MIR4437 ENSG00000238171 LINC01934
GH02I181275 Enhancer 0.7 Ensembl ENCODE 0.3 +29.8 29823 1 CTCF NR2F1 RUNX3 THRB ITGA4 UBE2E3 MIR4437 ENSG00000238171 LINC01934
GH02I181252 Enhancer 0.8 FANTOM5 Ensembl ENCODE 0.2 +52.8 52829 1.1 HLF ZNF143 ITGA4 MIR4437 ENSG00000238171 LINC01934
GH02I181298 Enhancer 0.3 dbSUPER 0.4 +6.3 6250 1.3 ZNF146 UBE2E3 MIR4437 ENSG00000238171 LINC01934
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR4437 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4437 Gene

Genomic Locations for MIR4437 Gene
chr2:181,305,593-181,305,652
(GRCh38/hg38)
Size:
60 bases
Orientation:
Minus strand
chr2:182,170,320-182,170,379
(GRCh37/hg19)

Genomic View for MIR4437 Gene

Genes around MIR4437 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4437 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4437 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4437 Gene

ORGUL Member Location for MIR4437 Gene

ORGUL Member Location for MIR4437 gene

Proteins for MIR4437 Gene

Post-translational modifications for MIR4437 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4437 Gene

Domains & Families for MIR4437 Gene

Gene Families for MIR4437 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4437: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4437 Gene

Function for MIR4437 Gene

Phenotypes From GWAS Catalog for MIR4437 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4437 Gene

Localization for MIR4437 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4437 Gene

Pathways & Interactions for MIR4437 Gene

SuperPathways for MIR4437 Gene

No Data Available

Interacting Proteins for MIR4437 Gene

Gene Ontology (GO) - Biological Process for MIR4437 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4437 Gene

Drugs & Compounds for MIR4437 Gene

No Compound Related Data Available

Transcripts for MIR4437 Gene

mRNA/cDNA for MIR4437 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4437 Gene

No ASD Table

Relevant External Links for MIR4437 Gene

GeneLoc Exon Structure for
MIR4437
ECgene alternative splicing isoforms for
MIR4437

Expression for MIR4437 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4437 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4437 Gene:

MIR4437
genes like me logo Genes that share expression patterns with MIR4437: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4437 Gene

Orthologs for MIR4437 Gene

Evolution for MIR4437 Gene

ENSEMBL:
Gene Tree for MIR4437 (if available)
TreeFam:
Gene Tree for MIR4437 (if available)

No data available for Orthologs for MIR4437 Gene

Paralogs for MIR4437 Gene

No data available for Paralogs for MIR4437 Gene

Variants for MIR4437 Gene

Sequence variations from dbSNP and Humsavar for MIR4437 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000305413 -- 181,307,435(-) C/T upstream_transcript_variant
rs1000613302 -- 181,306,331(-) A/G upstream_transcript_variant
rs1000655871 -- 181,306,959(-) A/G upstream_transcript_variant
rs1002386621 -- 181,305,255(-) T/C downstream_transcript_variant
rs1003271913 -- 181,306,525(-) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4437 Gene

Variant ID Type Subtype PubMed ID
esv3584213 CNV loss 25503493
esv3893514 CNV gain 25118596
nsv954441 CNV duplication 24416366

Additional Variant Information for MIR4437 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4437

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4437 Gene

Disorders for MIR4437 Gene

Additional Disease Information for MIR4437

No disorders were found for MIR4437 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4437 Gene

Publications for MIR4437 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 58
  2. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3 58
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR4437 Gene

Sources for MIR4437 Gene

Content
Loading form....