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Aliases for MIR4436B2 Gene

Subcategory (RNA class) for MIR4436B2 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4436B2 Gene

  • MicroRNA 4436b-2 2 3 5
  • Hsa-Mir-4436b-2 3

External Ids for MIR4436B2 Gene

Previous GeneCards Identifiers for MIR4436B2 Gene

  • GC02U902489
  • GC02P111046

Summaries for MIR4436B2 Gene

Entrez Gene Summary for MIR4436B2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4436B2 Gene

MIR4436B2 (MicroRNA 4436b-2) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4436B2 Gene

Genomics for MIR4436B2 Gene

Regulatory Elements for MIR4436B2 Gene

Enhancers for MIR4436B2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MIR4436B2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4436B2 Gene

Chromosome:
2
Start:
110,284,853 bp from pter
End:
110,284,943 bp from pter
Size:
91 bases
Orientation:
Plus strand

Genomic View for MIR4436B2 Gene

Genes around MIR4436B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4436B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4436B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4436B2 Gene

Proteins for MIR4436B2 Gene

Post-translational modifications for MIR4436B2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4436B2 Gene

Domains & Families for MIR4436B2 Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4436B2 Gene

Function for MIR4436B2 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4436B2 Gene

Localization for MIR4436B2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4436B2 Gene

Pathways & Interactions for MIR4436B2 Gene

SuperPathways for MIR4436B2 Gene

No Data Available

Interacting Proteins for MIR4436B2 Gene

Gene Ontology (GO) - Biological Process for MIR4436B2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4436B2 Gene

Drugs & Compounds for MIR4436B2 Gene

No Compound Related Data Available

Transcripts for MIR4436B2 Gene

mRNA/cDNA for MIR4436B2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4436B2 Gene

No ASD Table

Relevant External Links for MIR4436B2 Gene

GeneLoc Exon Structure for
MIR4436B2
ECgene alternative splicing isoforms for
MIR4436B2

Expression for MIR4436B2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4436B2 Gene:

MIR4436B2
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4436B2 Gene

Orthologs for MIR4436B2 Gene

Evolution for MIR4436B2 Gene

ENSEMBL:
Gene Tree for MIR4436B2 (if available)
TreeFam:
Gene Tree for MIR4436B2 (if available)

No data available for Orthologs for MIR4436B2 Gene

Paralogs for MIR4436B2 Gene

No data available for Paralogs for MIR4436B2 Gene

Variants for MIR4436B2 Gene

Sequence variations from dbSNP and Humsavar for MIR4436B2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs766665132 -- 110,283,544(+) ACTGC(-/A)AAAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4436B2 Gene

Variant ID Type Subtype PubMed ID
dgv1162e212 CNV gain 25503493
dgv1163e212 CNV loss 25503493
dgv154e55 CNV loss 17911159
dgv155e55 CNV gain 17911159
dgv4037n100 CNV gain 25217958
dgv4038n100 CNV loss 25217958
dgv4041n100 CNV gain 25217958
dgv4044n100 CNV gain+loss 25217958
dgv471n27 CNV gain 19166990
dgv472n27 CNV loss 19166990
dgv6999n54 CNV gain 21841781
dgv7000n54 CNV loss 21841781
dgv7001n54 CNV gain+loss 21841781
dgv7002n54 CNV loss 21841781
esv2556499 CNV gain 19546169
esv2751812 CNV loss 17911159
esv3575292 CNV gain 25503493
esv3584010 CNV loss 25503493
esv3893070 CNV gain+loss 25118596
nsv1003103 CNV gain+loss 25217958
nsv1010477 CNV gain+loss 25217958
nsv1149522 OTHER inversion 26484159
nsv458751 CNV loss 19166990
nsv470479 CNV gain 18288195
nsv499578 OTHER inversion 21111241
nsv510884 OTHER complex 20534489
nsv515996 CNV gain+loss 19592680
nsv582654 CNV loss 21841781
nsv582658 CNV loss 21841781
nsv7324 OTHER inversion 18451855
nsv818076 CNV loss 17921354
nsv834329 CNV gain 17160897
nsv961859 CNV duplication 23825009

Relevant External Links for MIR4436B2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4436B2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4436B2 Gene

Disorders for MIR4436B2 Gene

Relevant External Links for MIR4436B2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4436B2

No disorders were found for MIR4436B2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4436B2 Gene

Publications for MIR4436B2 Gene

  1. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 65
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 65

Products for MIR4436B2 Gene

Sources for MIR4436B2 Gene

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