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Aliases for MIR4435-2 Gene

Subcategory (RNA class) for MIR4435-2 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR4435-2 Gene

  • MicroRNA 4435-2 2 3 5
  • Hsa-Mir-4435-2 3
  • Mir-4435-2 3

External Ids for MIR4435-2 Gene

Previous GeneCards Identifiers for MIR4435-2 Gene

  • GC02U902421
  • GC02M112078

Summaries for MIR4435-2 Gene

Entrez Gene Summary for MIR4435-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4435-2 Gene

MIR4435-2 (MicroRNA 4435-2) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4435-2 Gene

Genomics for MIR4435-2 Gene

Regulatory Elements for MIR4435-2 Gene

Enhancers for MIR4435-2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F111320 1.2 Ensembl ENCODE 0.8 -0.2 -157 1.9 MTA2 NR2F1 TAL1 MAFG ARID1B ZNF316 NCOR1 NFE2L1 NFE2 FOS ENSG00000279191 MIR4435-2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR4435-2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4435-2 Gene

Chromosome:
2
Start:
111,321,013 bp from pter
End:
111,321,086 bp from pter
Size:
74 bases
Orientation:
Minus strand

Genomic View for MIR4435-2 Gene

Genes around MIR4435-2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4435-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4435-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4435-2 Gene

ORGUL Member Location for MIR4435-2 Gene

ORGUL Member Location for MIR4435-2 gene

Proteins for MIR4435-2 Gene

Post-translational modifications for MIR4435-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4435-2 Gene

Domains & Families for MIR4435-2 Gene

Gene Families for MIR4435-2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4435-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4435-2 Gene

Function for MIR4435-2 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4435-2 Gene

Localization for MIR4435-2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4435-2 Gene

Pathways & Interactions for MIR4435-2 Gene

SuperPathways for MIR4435-2 Gene

No Data Available

Interacting Proteins for MIR4435-2 Gene

Gene Ontology (GO) - Biological Process for MIR4435-2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4435-2 Gene

Transcripts for MIR4435-2 Gene

mRNA/cDNA for MIR4435-2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4435-2 Gene

No ASD Table

Relevant External Links for MIR4435-2 Gene

GeneLoc Exon Structure for
MIR4435-2
ECgene alternative splicing isoforms for
MIR4435-2

Expression for MIR4435-2 Gene

mRNA expression in normal human tissues for MIR4435-2 Gene

genes like me logo Genes that share expression patterns with MIR4435-2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4435-2 Gene

Orthologs for MIR4435-2 Gene

Evolution for MIR4435-2 Gene

ENSEMBL:
Gene Tree for MIR4435-2 (if available)
TreeFam:
Gene Tree for MIR4435-2 (if available)

No data available for Orthologs for MIR4435-2 Gene

Paralogs for MIR4435-2 Gene

No data available for Paralogs for MIR4435-2 Gene

Variants for MIR4435-2 Gene

Sequence variations from dbSNP and Humsavar for MIR4435-2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs111674772 -- 111,321,642(+) AGAGC(A/G)TCTTC intron-variant, upstream-variant-2KB
rs138769097 -- 111,322,599(+) GACAG(C/T)AGAAT intron-variant, upstream-variant-2KB
rs143549734 -- 111,320,581(+) GGTAT(C/T)CTAGT intron-variant, downstream-variant-500B
rs182503044 -- 111,321,632(+) GTTTT(C/T)GGATA intron-variant, upstream-variant-2KB
rs184969031 -- 111,321,686(+) AGACG(C/T)TCTTC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4435-2 Gene

Variant ID Type Subtype PubMed ID
dgv3887n100 CNV gain 25217958
dgv3888n100 CNV gain 25217958
dgv3889n100 CNV loss 25217958
dgv3892n100 CNV gain+loss 25217958
dgv3893n100 CNV gain 25217958
dgv3899n100 CNV loss 25217958
dgv3900n100 CNV gain 25217958
dgv3901n100 CNV gain+loss 25217958
dgv3906n100 CNV gain+loss 25217958
dgv3908n100 CNV gain 25217958
dgv3909n100 CNV loss 25217958
dgv3910n100 CNV gain 25217958
dgv3911n100 CNV gain+loss 25217958
dgv3912n100 CNV loss 25217958
dgv4047n100 CNV loss 25217958
dgv4049n100 CNV gain 25217958
dgv4050n100 CNV gain 25217958
dgv4051n100 CNV gain 25217958
dgv61n16 CNV deletion 17901297
dgv719e214 CNV gain 21293372
dgv731e214 CNV gain 21293372
esv2422072 CNV deletion 20811451
esv26325 CNV gain+loss 19812545
esv26476 CNV gain+loss 19812545
esv2759073 CNV gain+loss 17122850
esv2759083 CNV gain+loss 17122850
esv2760646 CNV gain+loss 21179565
esv2763649 CNV gain+loss 21179565
esv33317 CNV gain 17666407
esv3591579 CNV loss 21293372
esv3893082 CNV gain 25118596
nsv1001093 CNV gain 25217958
nsv1001733 CNV gain+loss 25217958
nsv1003669 CNV loss 25217958
nsv1004578 CNV loss 25217958
nsv10068 CNV gain+loss 18304495
nsv10126 CNV gain+loss 18304495
nsv1014545 CNV gain 25217958
nsv1072005 CNV deletion 25765185
nsv1115574 CNV duplication 24896259
nsv1130752 CNV deletion 24896259
nsv1148611 CNV deletion 26484159
nsv1149522 OTHER inversion 26484159
nsv1160815 CNV deletion 26073780
nsv2876 CNV insertion 18451855
nsv428398 CNV loss 18775914
nsv428402 CNV loss 18775914
nsv441767 CNV gain+loss 18776908
nsv441774 CNV gain 18776908
nsv469744 CNV gain 16826518
nsv516958 CNV gain+loss 19592680
nsv521956 CNV loss 19592680
nsv522475 CNV gain 19592680
nsv582374 CNV gain 21841781
nsv582375 CNV loss 21841781
nsv582379 CNV loss 21841781
nsv582380 CNV loss 21841781
nsv582699 CNV loss 21841781
nsv818077 CNV gain 17921354
nsv821628 CNV gain 15273396
nsv829491 CNV gain 20364138
nsv834286 CNV gain 17160897
nsv961432 CNV duplication 23825009
nsv961868 CNV duplication 23825009

Relevant External Links for MIR4435-2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4435-2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4435-2 Gene

Disorders for MIR4435-2 Gene

Relevant External Links for MIR4435-2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4435-2

No disorders were found for MIR4435-2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4435-2 Gene

Publications for MIR4435-2 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  2. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima D.D. … Dave S.S. (Blood 2010) 3 64
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4435-2 Gene

Sources for MIR4435-2 Gene

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