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Aliases for MIR4434 Gene

Subcategory (RNA class) for MIR4434 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4434 Gene

  • MicroRNA 4434 2 3 5
  • Hsa-Mir-4434 3

External Ids for MIR4434 Gene

Previous GeneCards Identifiers for MIR4434 Gene

  • GC02U902437
  • GC02P064754

Summaries for MIR4434 Gene

Entrez Gene Summary for MIR4434 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4434 Gene

MIR4434 (MicroRNA 4434) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4434 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4434 Gene

Genomics for MIR4434 Gene

Regulatory Elements for MIR4434 Gene

Enhancers for MIR4434 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H064522 1.1 ENCODE 0.7 -0.6 -601 4 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 YBX1 ZBTB7B YY1 AFTPH MIR4434 LOC101927402
GH02H064534 0.7 Ensembl 0.4 +9.2 9188 0 NR2F1 JUNB ELF1 BATF IKZF1 EED ETV6 RUNX3 IKZF2 SPI1 MIR4434 LOC105374773
GH02H064542 0.7 ENCODE 0.4 +17.3 17319 0 FOXA2 HLF PPARG FOXA1 ZGPAT ZNF316 CREB1 KLF9 NR2F6 HNF4A AFTPH LOC105374773 MIR4434
GH02H064527 0.4 Ensembl 0.7 +2.5 2488 0 ATF1 MIR4434 LOC105374773
GH02H064545 0.5 FANTOM5 0.3 +20.5 20512 0 SOX13 ZNF362 AFTPH SLC1A4 LOC105374773 MIR4434
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4434 on UCSC Golden Path with GeneCards custom track

Promoters for MIR4434 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000117962 -1112 3600 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 YBX1 ZBTB7B YY1

Genomic Location for MIR4434 Gene

Chromosome:
2
Start:
64,525,513 bp from pter
End:
64,525,565 bp from pter
Size:
53 bases
Orientation:
Plus strand

Genomic View for MIR4434 Gene

Genes around MIR4434 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4434 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4434 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4434 Gene

Proteins for MIR4434 Gene

Post-translational modifications for MIR4434 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4434 Gene

Domains & Families for MIR4434 Gene

Gene Families for MIR4434 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4434: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4434 Gene

Function for MIR4434 Gene

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR4434
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4434 Gene

Localization for MIR4434 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4434 Gene

Pathways & Interactions for MIR4434 Gene

SuperPathways for MIR4434 Gene

No Data Available

Interacting Proteins for MIR4434 Gene

Gene Ontology (GO) - Biological Process for MIR4434 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4434 Gene

Drugs & Compounds for MIR4434 Gene

No Compound Related Data Available

Transcripts for MIR4434 Gene

mRNA/cDNA for MIR4434 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR4434
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4434 Gene

No ASD Table

Relevant External Links for MIR4434 Gene

GeneLoc Exon Structure for
MIR4434
ECgene alternative splicing isoforms for
MIR4434

Expression for MIR4434 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4434 Gene:

MIR4434
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4434 Gene

Orthologs for MIR4434 Gene

Evolution for MIR4434 Gene

ENSEMBL:
Gene Tree for MIR4434 (if available)
TreeFam:
Gene Tree for MIR4434 (if available)

No data available for Orthologs for MIR4434 Gene

Paralogs for MIR4434 Gene

No data available for Paralogs for MIR4434 Gene

Variants for MIR4434 Gene

Sequence variations from dbSNP and Humsavar for MIR4434 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000101717 -- 64,525,598(+) GGATT(G/T)TATTT intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1000113001 -- 64,526,007(+) TACAC(A/G)TATAT intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1002165365 -- 64,524,486(+) CTGAC(A/G)GGGCT intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1003460636 -- 64,523,777(+) GCTGC(C/T)TTCCC intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1005130181 -- 64,525,472(+) TGGGC(-/G)GGGGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4434 Gene

Variant ID Type Subtype PubMed ID
nsv1006553 CNV gain 25217958
nsv2754 CNV insertion 18451855
nsv582127 CNV gain 21841781
nsv7313 OTHER inversion 18451855
nsv834245 CNV gain 17160897

Relevant External Links for MIR4434 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4434

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4434 Gene

Disorders for MIR4434 Gene

Relevant External Links for MIR4434

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4434

No disorders were found for MIR4434 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4434 Gene

Publications for MIR4434 Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3 60
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 60

Products for MIR4434 Gene

Sources for MIR4434 Gene

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