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Aliases for MIR4430 Gene

Subcategory (RNA class) for MIR4430 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4430 Gene

  • MicroRNA 4430 2 3 5
  • Hsa-Mir-4430 3

External Ids for MIR4430 Gene

Previous GeneCards Identifiers for MIR4430 Gene

  • GC02U902436
  • GC02P033645

Summaries for MIR4430 Gene

Entrez Gene Summary for MIR4430 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4430 Gene

MIR4430 (MicroRNA 4430) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4430 Gene

Genomics for MIR4430 Gene

Regulatory Elements for MIR4430 Gene

Enhancers for MIR4430 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F033411 1 Ensembl ENCODE 0.4 -6.4 -6359 1.7 CTCF ATF1 JUN CHD4 ZIC2 RAD21 ZKSCAN1 GATA3 SMC3 FOS RASGRP3 ENSG00000206951 LTBP1 MIR4430 PIR50335
GH02F033419 0.4 Ensembl 0.8 +1.5 1485 0.4 ZFHX2 EGR2 MIR4430 RASGRP3
GH02F033426 0.8 Ensembl ENCODE 0.4 +8.3 8343 1.1 JUND PKNOX1 NFIA L3MBTL2 SIN3A CEBPB REST RASGRP3 MIR4430
GH02F033425 0.8 Ensembl ENCODE 0.4 +7.3 7286 0.4 JUND JUN TCF7L2 EGR2 MIR4430 RASGRP3
GH02F033420 0.3 FANTOM5 0.8 +2.4 2361 0.5 RASGRP3 MIR4430
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4430 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4430 Gene

Chromosome:
2
Start:
33,418,516 bp from pter
End:
33,418,564 bp from pter
Size:
49 bases
Orientation:
Plus strand

Genomic View for MIR4430 Gene

Genes around MIR4430 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4430 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4430 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4430 Gene

Proteins for MIR4430 Gene

Post-translational modifications for MIR4430 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4430 Gene

Domains & Families for MIR4430 Gene

Gene Families for MIR4430 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4430: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4430 Gene

Function for MIR4430 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4430 Gene

Localization for MIR4430 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4430 Gene

Pathways & Interactions for MIR4430 Gene

SuperPathways for MIR4430 Gene

No Data Available

Interacting Proteins for MIR4430 Gene

Gene Ontology (GO) - Biological Process for MIR4430 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4430 Gene

Transcripts for MIR4430 Gene

mRNA/cDNA for MIR4430 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4430 Gene

No ASD Table

Relevant External Links for MIR4430 Gene

GeneLoc Exon Structure for
MIR4430
ECgene alternative splicing isoforms for
MIR4430

Expression for MIR4430 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4430 Gene:

MIR4430
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4430 Gene

Orthologs for MIR4430 Gene

Evolution for MIR4430 Gene

ENSEMBL:
Gene Tree for MIR4430 (if available)
TreeFam:
Gene Tree for MIR4430 (if available)

No data available for Orthologs for MIR4430 Gene

Paralogs for MIR4430 Gene

No data available for Paralogs for MIR4430 Gene

Variants for MIR4430 Gene

Sequence variations from dbSNP and Humsavar for MIR4430 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs111477814 -- 33,417,929(+) AAAAA(A/C)GAAAA upstream-variant-2KB
rs112328166 -- 33,416,596(+) CTTGA(-/CCT)CCTGC upstream-variant-2KB
rs112477246 -- 33,418,412(+) GACCC(C/T)ATCTG upstream-variant-2KB
rs112499213 -- 33,418,826(+) CCACC(A/G)TGCCT downstream-variant-500B
rs114083402 -- 33,418,005(+) CTTTC(C/T)ATGGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4430 Gene

Variant ID Type Subtype PubMed ID
esv3891725 CNV gain 25118596
esv3590286 CNV loss 21293372

Relevant External Links for MIR4430 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4430

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4430 Gene

Disorders for MIR4430 Gene

Relevant External Links for MIR4430

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4430

No disorders were found for MIR4430 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4430 Gene

Publications for MIR4430 Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima D.D. … Dave S.S. (Blood 2010) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4430 Gene

Sources for MIR4430 Gene

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