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Aliases for MIR4428 Gene

Subcategory (RNA class) for MIR4428 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4428 Gene

  • MicroRNA 4428 2 3 5
  • Hsa-Mir-4428 3

External Ids for MIR4428 Gene

Previous GeneCards Identifiers for MIR4428 Gene

  • GC01U903286
  • GC01P237636

Summaries for MIR4428 Gene

Entrez Gene Summary for MIR4428 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4428 Gene

MIR4428 (MicroRNA 4428) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4428 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4428 Gene

Genomics for MIR4428 Gene

Regulatory Elements for MIR4428 Gene

Enhancers for MIR4428 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H237471 0.7 ENCODE 0.7 0.0 -44 0 TBP MXI1 ZBTB21 MAX RFX5 HIC1 POLR2A ZNF366 KLF8 ZNF202 ENSG00000273058 ENSG00000230325 HEATR1 MTR MIR4428 GC01P237314
GH01H237481 0.4 FANTOM5 0.4 +10.8 10781 0 ZNF362 RYR2 MIR4428 ENSG00000252290
GH01H237314 0.6 dbSUPER 0.1 -149.6 -149638 13 ZNF781 ZFHX2 POLR2A PRDM1 TRIM28 EGR2 SETDB1 ZNF112 ZBTB1 ENSG00000230325 GC01P237314 MIR4428
GH01H237338 0.4 dbSUPER 0.1 -130.8 -130773 3 CREB1 GC01P237314 MIR4428
GH01H237346 0.3 FANTOM5 0.1 -124.6 -124648 0 RYR2 GC01P237314 MIR4428
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4428 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4428 Gene

Chromosome:
1
Start:
237,471,119 bp from pter
End:
237,471,191 bp from pter
Size:
73 bases
Orientation:
Plus strand

Genomic View for MIR4428 Gene

Genes around MIR4428 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4428 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4428 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4428 Gene

Proteins for MIR4428 Gene

Post-translational modifications for MIR4428 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4428 Gene

Domains & Families for MIR4428 Gene

Gene Families for MIR4428 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4428: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4428 Gene

Function for MIR4428 Gene

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR4428
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4428 Gene

Localization for MIR4428 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4428 Gene

Pathways & Interactions for MIR4428 Gene

SuperPathways for MIR4428 Gene

No Data Available

Interacting Proteins for MIR4428 Gene

Gene Ontology (GO) - Biological Process for MIR4428 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4428 Gene

Drugs & Compounds for MIR4428 Gene

No Compound Related Data Available

Transcripts for MIR4428 Gene

mRNA/cDNA for MIR4428 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR4428
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4428 Gene

No ASD Table

Relevant External Links for MIR4428 Gene

GeneLoc Exon Structure for
MIR4428
ECgene alternative splicing isoforms for
MIR4428

Expression for MIR4428 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4428 Gene:

MIR4428
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4428 Gene

Orthologs for MIR4428 Gene

Evolution for MIR4428 Gene

ENSEMBL:
Gene Tree for MIR4428 (if available)
TreeFam:
Gene Tree for MIR4428 (if available)

No data available for Orthologs for MIR4428 Gene

Paralogs for MIR4428 Gene

No data available for Paralogs for MIR4428 Gene

Variants for MIR4428 Gene

Sequence variations from dbSNP and Humsavar for MIR4428 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs371262363 Likely benign 237,469,144(+) TCCCT(A/C/T)GACTG nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon
rs773609522 Uncertain significance 237,469,154(+) GGTTG(A/G)TCAGC nc-transcript-variant, upstream-variant-2KB, reference, missense
rs794728722 Uncertain significance 237,469,120(+) AAAAA(A/C)TGTGC nc-transcript-variant, upstream-variant-2KB, reference, missense
rs1001999014 -- 237,471,129(+) AGGTG(C/T)CATGT intron-variant, nc-transcript-variant
rs1003155782 -- 237,471,039(+) TTGGA(C/G)TCGGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4428 Gene

Variant ID Type Subtype PubMed ID
nsv1006191 CNV gain 25217958
nsv549415 CNV gain 21841781

Relevant External Links for MIR4428 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4428

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4428 Gene

Disorders for MIR4428 Gene

Relevant External Links for MIR4428

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4428

No disorders were found for MIR4428 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4428 Gene

Publications for MIR4428 Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3 60
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 60

Products for MIR4428 Gene

Sources for MIR4428 Gene

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