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Aliases for MIR4427 Gene

Subcategory (RNA class) for MIR4427 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4427 Gene

  • MicroRNA 4427 2 3 5
  • Hsa-Mir-4427 3

External Ids for MIR4427 Gene

Previous GeneCards Identifiers for MIR4427 Gene

  • GC01U903255
  • GC01P233761

Summaries for MIR4427 Gene

Entrez Gene Summary for MIR4427 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4427 Gene

MIR4427 (MicroRNA 4427) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4427 Gene

Genomics for MIR4427 Gene

Regulatory Elements for MIR4427 Gene

Enhancers for MIR4427 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F233627 0.3 FANTOM5 0.8 +3.4 3444 0.1 ZFHX2 EGR2 KCNK1 MIR4427 GC01P233696
GH01F233613 1.1 FANTOM5 ENCODE 0.4 -9.3 -9349 3.2 HDGF PKNOX1 CREB3L1 WRNIP1 SIN3A FEZF1 ZNF2 YY1 ZNF263 SP3 LOC102724100 LOC105373206 IRF2BP2 RNU1-74P LINC01745 ENSG00000230404 LINC01744 RPS7P3 KCNK1 MIR4427
GH01F233635 0.8 ENCODE 0.4 +12.0 11952 1.6 PKNOX1 ARNT CREB3L1 FEZF1 ZNF2 CBX5 ZNF302 ZNF416 ZNF548 FOS RPS7P3 IRF2BP2 KCNK1 MIR4427 GC01P233696
GH01F233654 0.2 ENCODE 0.3 +31.6 31550 2.4 HDGF PKNOX1 SIN3A FEZF1 ZNF2 GATA2 ZNF143 FOS ZNF263 REST KCNK1 MIR4427 GC01P233696
GH01F233665 0.5 ENCODE 0.2 +42.0 41996 0.7 PKNOX1 ATF1 ARNT CREB3L1 CBX5 ELK1 GATA2 KLF13 NCOA1 REST KCNK1 GC01P233696 MIR4427
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR4427 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4427 Gene

Chromosome:
1
Start:
233,624,152 bp from pter
End:
233,624,219 bp from pter
Size:
68 bases
Orientation:
Plus strand

Genomic View for MIR4427 Gene

Genes around MIR4427 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4427 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4427 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4427 Gene

Proteins for MIR4427 Gene

Post-translational modifications for MIR4427 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4427 Gene

Domains & Families for MIR4427 Gene

Gene Families for MIR4427 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4427: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4427 Gene

Function for MIR4427 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4427 Gene

Localization for MIR4427 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4427 Gene

Pathways & Interactions for MIR4427 Gene

SuperPathways for MIR4427 Gene

No Data Available

Interacting Proteins for MIR4427 Gene

Gene Ontology (GO) - Biological Process for MIR4427 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4427 Gene

Transcripts for MIR4427 Gene

mRNA/cDNA for MIR4427 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4427 Gene

No ASD Table

Relevant External Links for MIR4427 Gene

GeneLoc Exon Structure for
MIR4427
ECgene alternative splicing isoforms for
MIR4427

Expression for MIR4427 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4427 Gene:

MIR4427
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4427 Gene

Orthologs for MIR4427 Gene

Evolution for MIR4427 Gene

ENSEMBL:
Gene Tree for MIR4427 (if available)
TreeFam:
Gene Tree for MIR4427 (if available)

No data available for Orthologs for MIR4427 Gene

Paralogs for MIR4427 Gene

No data available for Paralogs for MIR4427 Gene

Variants for MIR4427 Gene

Sequence variations from dbSNP and Humsavar for MIR4427 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs113349068 -- 233,622,724(+) CTTGA(A/G)TCAGA intron-variant, upstream-variant-2KB
rs113702996 -- 233,624,664(+) AGATA(C/T)AACTT intron-variant, downstream-variant-500B
rs115472144 -- 233,622,551(+) GCATG(A/G)ATCCC intron-variant, upstream-variant-2KB
rs116759866 -- 233,623,028(+) GAGTC(A/G)GTGAA intron-variant, upstream-variant-2KB
rs118043131 -- 233,623,605(+) TGTTA(C/T)TGAGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4427 Gene

Variant ID Type Subtype PubMed ID
nsv528071 CNV loss 19592680

Relevant External Links for MIR4427 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4427

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4427 Gene

Disorders for MIR4427 Gene

Relevant External Links for MIR4427

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4427

No disorders were found for MIR4427 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4427 Gene

Publications for MIR4427 Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima D.D. … Dave S.S. (Blood 2010) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4427 Gene

Sources for MIR4427 Gene

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