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Aliases for MIR4425 Gene

Subcategory (RNA class) for MIR4425 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4425 Gene

  • MicroRNA 4425 2 3 5
  • Hsa-Mir-4425 3

External Ids for MIR4425 Gene

Previous GeneCards Identifiers for MIR4425 Gene

  • GC01U903275
  • GC01P025351

Summaries for MIR4425 Gene

Entrez Gene Summary for MIR4425 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4425 Gene

MIR4425 (MicroRNA 4425) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4425 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4425 Gene

Genomics for MIR4425 Gene

GeneHancer (GH) Regulatory Elements for MIR4425 Gene

Promoters and enhancers for MIR4425 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I025020 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 550.8 -0.8 -810 4.9 HDGF PKNOX1 SMAD1 ZFP64 YBX1 IRF4 GLIS2 ARID2 ZNF207 ZNF143 MIR4425 RUNX3 LOC105376878 RSRP1 SYF2 SRRM1 GC01M024955
GH01I025018 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 0.8 -4.3 -4313 1.3 HDGF BCOR ZSCAN4 ZMYM3 PAX8 EBF1 BATF RELA POLR2A ADNP RUNX3 MIR4425 GC01M024955
GH01I025027 Enhancer 1 FANTOM5 dbSUPER 0.8 +3.7 3711 0.3 SMAD1 EBF1 RELA ZNF143 ZNF207 ETV6 BCLAF1 IKZF2 RUNX3 SMARCA5 RSRP1 RUNX3 SYF2 MIR4425 LOC105376879
GH01I025030 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 0.4 +10.1 10055 6.2 HDGF PKNOX1 SMAD1 FEZF1 YBX1 GLI4 IRF4 ZNF207 ATF7 RUNX3 SRRM1 MAN1C1 RUNX3 SYF2 LOC105376878 ENSG00000261349 STMN1 RSRP1 SDHDP6 LOC105376879
GH01I025026 Enhancer 0.8 FANTOM5 dbSUPER 0.8 +3.3 3307 0.2 CTCF IKZF1 NBN ZNF207 ZNF592 MYOM3 RSRP1 RUNX3 SYF2 MIR4425 LOC105376879
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR4425 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4425 Gene

Genomic Locations for MIR4425 Gene
chr1:25,023,503-25,023,586
(GRCh38/hg38)
Size:
84 bases
Orientation:
Plus strand
chr1:25,349,994-25,350,077
(GRCh37/hg19)

Genomic View for MIR4425 Gene

Genes around MIR4425 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4425 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4425 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4425 Gene

Proteins for MIR4425 Gene

Post-translational modifications for MIR4425 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4425 Gene

Domains & Families for MIR4425 Gene

Gene Families for MIR4425 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4425: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4425 Gene

Function for MIR4425 Gene

Phenotypes From GWAS Catalog for MIR4425 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4425 Gene

Localization for MIR4425 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4425 Gene

Pathways & Interactions for MIR4425 Gene

SuperPathways for MIR4425 Gene

No Data Available

Interacting Proteins for MIR4425 Gene

Gene Ontology (GO) - Biological Process for MIR4425 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4425 Gene

Drugs & Compounds for MIR4425 Gene

No Compound Related Data Available

Transcripts for MIR4425 Gene

mRNA/cDNA for MIR4425 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4425 Gene

No ASD Table

Relevant External Links for MIR4425 Gene

GeneLoc Exon Structure for
MIR4425
ECgene alternative splicing isoforms for
MIR4425

Expression for MIR4425 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4425 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4425 Gene:

MIR4425
genes like me logo Genes that share expression patterns with MIR4425: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4425 Gene

Orthologs for MIR4425 Gene

Evolution for MIR4425 Gene

ENSEMBL:
Gene Tree for MIR4425 (if available)
TreeFam:
Gene Tree for MIR4425 (if available)

No data available for Orthologs for MIR4425 Gene

Paralogs for MIR4425 Gene

No data available for Paralogs for MIR4425 Gene

Variants for MIR4425 Gene

Sequence variations from dbSNP and Humsavar for MIR4425 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000248320 -- 25,023,783(+) G/A/T downstream_transcript_variant
rs1002340903 -- 25,021,814(+) T/A upstream_transcript_variant
rs1002707959 -- 25,022,605(+) G/A upstream_transcript_variant
rs1004811416 -- 25,023,198(+) G/C upstream_transcript_variant
rs1006434919 -- 25,023,022(+) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4425 Gene

Variant ID Type Subtype PubMed ID
dgv132n100 CNV gain 25217958
esv3576582 CNV gain 25503493

Additional Variant Information for MIR4425 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4425

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4425 Gene

Disorders for MIR4425 Gene

Additional Disease Information for MIR4425

No disorders were found for MIR4425 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4425 Gene

Publications for MIR4425 Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3 58
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR4425 Gene

Sources for MIR4425 Gene

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