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Aliases for MIR4424 Gene

Subcategory (RNA class) for MIR4424 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4424 Gene

  • MicroRNA 4424 2 3 5
  • Hsa-Mir-4424 3

External Ids for MIR4424 Gene

Previous GeneCards Identifiers for MIR4424 Gene

  • GC01U903280

Summaries for MIR4424 Gene

Entrez Gene Summary for MIR4424 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4424 Gene

MIR4424 (MicroRNA 4424) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4424 Gene

Genomics for MIR4424 Gene

Regulatory Elements for MIR4424 Gene

Enhancers for MIR4424 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F178682 1.2 Ensembl ENCODE 0.8 +4.9 4935 0.2 ELF3 MLX ARID4B THRB ZSCAN9 RAD21 DNMT3B RARA SCRT2 CREM MIR4424 GC01P178687
GH01F178683 1 Ensembl ENCODE 0.4 +7.1 7109 2.9 TBP MTA2 JUN CEBPB JUNB ZNF384 TBX21 EP300 RARA RFX5 RALGPS2 GC01P178687 MIR4424
GH01F178650 1.2 Ensembl ENCODE 0.3 -25.5 -25508 3.4 MLX ARID4B DMAP1 ZNF48 YY1 FOS SP5 NFYC MIER2 REST RALGPS2 C1orf220 ANGPTL1 ENSG00000273384 MIR4424
GH01F178664 0.8 Ensembl ENCODE 0.4 -13.2 -13181 0.5 CTCF RAD51 USF1 USF2 NBN SPI1 MIR4424 ENSG00000273384
GH01F178659 1 Ensembl ENCODE 0.3 -17.9 -17866 0.6 PKNOX1 MXI1 TBL1XR1 BMI1 RELA CREM MTA2 CBFB ZBED1 TRIM22 RALGPS2 ENSG00000273384 MIR4424
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4424 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4424 Gene

Chromosome:
1
Start:
178,677,749 bp from pter
End:
178,677,834 bp from pter
Size:
86 bases
Orientation:
Plus strand

Genomic View for MIR4424 Gene

Genes around MIR4424 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4424 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4424 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4424 Gene

Proteins for MIR4424 Gene

Post-translational modifications for MIR4424 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4424 Gene

Domains & Families for MIR4424 Gene

Gene Families for MIR4424 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4424: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4424 Gene

Function for MIR4424 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4424 Gene

Localization for MIR4424 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4424 Gene

Pathways & Interactions for MIR4424 Gene

SuperPathways for MIR4424 Gene

No Data Available

Interacting Proteins for MIR4424 Gene

Gene Ontology (GO) - Biological Process for MIR4424 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4424 Gene

Transcripts for MIR4424 Gene

mRNA/cDNA for MIR4424 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4424 Gene

No ASD Table

Relevant External Links for MIR4424 Gene

GeneLoc Exon Structure for
MIR4424
ECgene alternative splicing isoforms for
MIR4424

Expression for MIR4424 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4424 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4424 Gene:

MIR4424
genes like me logo Genes that share expression patterns with MIR4424: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4424 Gene

Orthologs for MIR4424 Gene

Evolution for MIR4424 Gene

ENSEMBL:
Gene Tree for MIR4424 (if available)
TreeFam:
Gene Tree for MIR4424 (if available)

No data available for Orthologs for MIR4424 Gene

Paralogs for MIR4424 Gene

No data available for Paralogs for MIR4424 Gene

Variants for MIR4424 Gene

Sequence variations from dbSNP and Humsavar for MIR4424 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10581905 -- 178,677,950(+) CCATC(-/A)AAAAA downstream-variant-500B
rs10913603 -- 178,676,425(+) gtatg(C/T)ctgaa upstream-variant-2KB
rs112052458 -- 178,677,885(+) AGGTG(A/G)AGGTT downstream-variant-500B
rs114278094 -- 178,676,108(+) GGTGC(A/G)GTGAC upstream-variant-2KB
rs114714585 -- 178,678,240(+) AGAGG(A/G)GAGGA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR4424 Gene

Variant ID Type Subtype PubMed ID
nsv548255 CNV loss 21841781
nsv548254 CNV gain 21841781
nsv466116 CNV loss 19166990
nsv437255 CNV loss 16327808

Relevant External Links for MIR4424 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4424

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4424 Gene

Disorders for MIR4424 Gene

Relevant External Links for MIR4424

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4424

No disorders were found for MIR4424 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4424 Gene

Publications for MIR4424 Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima D.D. … Dave S.S. (Blood 2010) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4424 Gene

Sources for MIR4424 Gene

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