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Aliases for MIR4423 Gene

Subcategory (RNA class) for MIR4423 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4423 Gene

  • MicroRNA 4423 2 3
  • Hsa-Mir-4423 3

External Ids for MIR4423 Gene

Previous GeneCards Identifiers for MIR4423 Gene

  • GC01U903285
  • GC01P085602

Summaries for MIR4423 Gene

Entrez Gene Summary for MIR4423 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4423 Gene

MIR4423 (MicroRNA 4423) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4423 Gene

Genomics for MIR4423 Gene

Genomic Location for MIR4423 Gene

Start:
85,133,794 bp from pter
End:
85,133,873 bp from pter
Size:
80 bases
Orientation:
Plus strand

Genomic View for MIR4423 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR4423 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4423 Gene

No data available for Regulatory Elements for MIR4423 Gene

Proteins for MIR4423 Gene

Post-translational modifications for MIR4423 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4423 Gene

Domains for MIR4423 Gene

Gene Families for MIR4423 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4423: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4423 Gene

Function for MIR4423 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR4423 Gene

Localization for MIR4423 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4423 Gene

Pathways for MIR4423 Gene

SuperPathways for MIR4423 Gene

No Data Available

Interacting Proteins for MIR4423 Gene

Gene Ontology (GO) - Biological Process for MIR4423 Gene

None

No data available for Pathways by source for MIR4423 Gene

Transcripts for MIR4423 Gene

mRNA/cDNA for MIR4423 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4423 Gene

No ASD Table

Relevant External Links for MIR4423 Gene

GeneLoc Exon Structure for
MIR4423
ECgene alternative splicing isoforms for
MIR4423

Expression for MIR4423 Gene

mRNA expression in normal human tissues for MIR4423 Gene

genes like me logo Genes that share expressions with MIR4423: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIR4423 Gene

Orthologs for MIR4423 Gene

Evolution for MIR4423 Gene

ENSEMBL:
Gene Tree for MIR4423 (if available)
TreeFam:
Gene Tree for MIR4423 (if available)

No data available for Orthologs for MIR4423 Gene

Paralogs for MIR4423 Gene

No data available for Paralogs for MIR4423 Gene

Variants for MIR4423 Gene

Sequence variations from dbSNP and Humsavar for MIR4423 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs817478 -- 85,133,880(+) CTGAG(A/C)CACAA downstream-variant-500B
rs10493760 -- 85,134,317(+) CTTAA(C/T)TTGCA downstream-variant-500B
rs11588689 -- 85,134,177(+) ACCAA(C/G)GTTTA downstream-variant-500B
rs34662731 -- 85,133,954(+) TGGGG(-/G)AATGA downstream-variant-500B
rs34868728 -- 85,133,817(+) CTTTT(-/T)GTTCC nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4423 Gene

Variant ID Type Subtype PubMed ID
esv34165 CNV Loss 18971310
nsv830459 CNV Loss 17160897

Relevant External Links for MIR4423 Gene

HapMap Linkage Disequilibrium report
MIR4423

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIR4423 Gene

Disorders for MIR4423 Gene

No disorders were found for MIR4423 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for MIR4423 Gene

Publications for MIR4423 Gene

  1. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  2. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima D.D. … Dave S.S. (Blood 2010) 3
  3. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3
  4. Deep sequencing of small RNAs from human skin reveals major alterations in the psoriasis miRNAome. (PMID: 21807764) Joyce C.E. … Bowcock A.M. (Hum. Mol. Genet. 2011) 3
  5. miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades. (PMID: 21911355) FriedlAonder M.R. … Rajewsky N. (Nucleic Acids Res. 2012) 3

Products for MIR4423 Gene

Sources for MIR4423 Gene

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