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Aliases for MIR4421 Gene

Subcategory (RNA class) for MIR4421 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4421 Gene

  • MicroRNA 4421 2 3 5
  • Hsa-Mir-4421 3

External Ids for MIR4421 Gene

Previous GeneCards Identifiers for MIR4421 Gene

  • GC01U903252
  • GC01P051527

Summaries for MIR4421 Gene

Entrez Gene Summary for MIR4421 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4421 Gene

MIR4421 (MicroRNA 4421) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4421 Gene

Genomics for MIR4421 Gene

Genomic Location for MIR4421 Gene

Chromosome:
1
Start:
51,059,837 bp from pter
End:
51,059,905 bp from pter
Size:
69 bases
Orientation:
Plus strand

Genomic View for MIR4421 Gene

Genes around MIR4421 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4421 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4421 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4421 Gene

No data available for Regulatory Elements for MIR4421 Gene

Proteins for MIR4421 Gene

Post-translational modifications for MIR4421 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4421 Gene

Domains & Families for MIR4421 Gene

Gene Families for MIR4421 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4421: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4421 Gene

Function for MIR4421 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4421 Gene

Localization for MIR4421 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4421 Gene

Pathways & Interactions for MIR4421 Gene

SuperPathways for MIR4421 Gene

No Data Available

Interacting Proteins for MIR4421 Gene

Gene Ontology (GO) - Biological Process for MIR4421 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4421 Gene

Drugs & Compounds for MIR4421 Gene

No Compound Related Data Available

Transcripts for MIR4421 Gene

mRNA/cDNA for MIR4421 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4421 Gene

No ASD Table

Relevant External Links for MIR4421 Gene

GeneLoc Exon Structure for
MIR4421
ECgene alternative splicing isoforms for
MIR4421

Expression for MIR4421 Gene

No Expression Related Data Available

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR4421 Gene

Orthologs for MIR4421 Gene

Evolution for MIR4421 Gene

ENSEMBL:
Gene Tree for MIR4421 (if available)
TreeFam:
Gene Tree for MIR4421 (if available)

No data available for Orthologs for MIR4421 Gene

Paralogs for MIR4421 Gene

No data available for Paralogs for MIR4421 Gene

Variants for MIR4421 Gene

Sequence variations from dbSNP and Humsavar for MIR4421 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs555018609 -- 51,057,946(+) TGCTG(A/G)GATTA upstream-variant-2KB
rs747998469 -- 51,057,880(+) CCATG(C/T)TGGCC upstream-variant-2KB
rs769291341 -- 51,057,888(+) GCCAA(A/G)CTGGT upstream-variant-2KB
rs537049647 -- 51,057,919(+) TGATC(C/T)ACCTG upstream-variant-2KB

Relevant External Links for MIR4421 Gene

HapMap Linkage Disequilibrium report
MIR4421

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR4421 Gene

Disorders for MIR4421 Gene

Relevant External Links for MIR4421

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4421

No disorders were found for MIR4421 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4421 Gene

Publications for MIR4421 Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima D.D. … Dave S.S. (Blood 2010) 3 67
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3

Products for MIR4421 Gene

Sources for MIR4421 Gene

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