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Aliases for MIR4420 Gene

Subcategory (RNA class) for MIR4420 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4420 Gene

  • MicroRNA 4420 2 3 5
  • Hsa-Mir-4420 3
  • Mir-4420 3

External Ids for MIR4420 Gene

Previous GeneCards Identifiers for MIR4420 Gene

  • GC01U903254
  • GC01M031216

Summaries for MIR4420 Gene

Entrez Gene Summary for MIR4420 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4420 Gene

MIR4420 (MicroRNA 4420) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4420 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4420 Gene

Genomics for MIR4420 Gene

Regulatory Elements for MIR4420 Gene

Enhancers for MIR4420 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H030737 2 FANTOM5 Ensembl ENCODE dbSUPER 0.4 -12.0 -12036 27 HDGF PKNOX1 ARNT SIN3A YY1 ZNF766 CBX5 ZNF302 ZNF416 ZNF143 SNRNP40 ENSG00000229447 LAPTM5 LOC400748 ENSG00000236335 MATN1 MATN1-AS1 PUM1 SDC3 LOC105378620
GH01H030726 1.5 Ensembl ENCODE dbSUPER 0.4 +9.2 9173 6 HDGF PKNOX1 ARNT YBX1 TCF12 ZNF766 FOS ATF7 RUNX3 ZC3H11A MATN1-AS1 MATN1 MIR4420
GH01H030734 0.8 dbSUPER 0.7 +4.0 4046 2 BCOR PKNOX1 BACH1 ZNF175 ZMYM3 CEBPG FOSL1 GTF3C2 ZNF766 MTA3 SNRNP40 ENSG00000229447 MATN1-AS1 MIR4420 MATN1
GH01H030733 0.9 ENCODE dbSUPER 0.4 +5.6 5614 0 ZC3H11A GABPA FOSL1 ZNF766 POLR2A HDAC2 NFE2 CUX1 ZNF584 MAFK MIR4420 MATN1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4420 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4420 Gene

Chromosome:
1
Start:
30,739,156 bp from pter
End:
30,739,232 bp from pter
Size:
77 bases
Orientation:
Minus strand

Genomic View for MIR4420 Gene

Genes around MIR4420 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4420 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4420 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4420 Gene

Proteins for MIR4420 Gene

Post-translational modifications for MIR4420 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4420 Gene

Domains & Families for MIR4420 Gene

Gene Families for MIR4420 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4420: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4420 Gene

Function for MIR4420 Gene

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR4420
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4420 Gene

Localization for MIR4420 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4420 Gene

Pathways & Interactions for MIR4420 Gene

SuperPathways for MIR4420 Gene

No Data Available

Interacting Proteins for MIR4420 Gene

Gene Ontology (GO) - Biological Process for MIR4420 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4420 Gene

Drugs & Compounds for MIR4420 Gene

No Compound Related Data Available

Transcripts for MIR4420 Gene

mRNA/cDNA for MIR4420 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR4420
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4420 Gene

No ASD Table

Relevant External Links for MIR4420 Gene

GeneLoc Exon Structure for
MIR4420
ECgene alternative splicing isoforms for
MIR4420

Expression for MIR4420 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4420 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4420 Gene:

MIR4420
genes like me logo Genes that share expression patterns with MIR4420: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4420 Gene

Orthologs for MIR4420 Gene

Evolution for MIR4420 Gene

ENSEMBL:
Gene Tree for MIR4420 (if available)
TreeFam:
Gene Tree for MIR4420 (if available)

No data available for Orthologs for MIR4420 Gene

Paralogs for MIR4420 Gene

No data available for Paralogs for MIR4420 Gene

Variants for MIR4420 Gene

Sequence variations from dbSNP and Humsavar for MIR4420 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1002126173 -- 30,739,622(+) TGCAG(C/G)TACAT intron-variant, upstream-variant-2KB
rs1002589545 -- 30,739,365(+) TGTGT(C/G)CTTGA intron-variant, upstream-variant-2KB
rs1003071303 -- 30,739,523(+) TCACT(-/C)CCAGC intron-variant, upstream-variant-2KB
rs1003122515 -- 30,740,611(+) TCCTG(A/G)TGTCT intron-variant, upstream-variant-2KB
rs1005582469 -- 30,739,159(+) CCGTC(C/T)CAGCT intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4420 Gene

Variant ID Type Subtype PubMed ID
dgv145n100 CNV gain 25217958
nsv460995 CNV gain 19166990
nsv509124 CNV insertion 20534489
nsv545947 CNV gain 21841781

Relevant External Links for MIR4420 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4420

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4420 Gene

Disorders for MIR4420 Gene

Relevant External Links for MIR4420

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4420

No disorders were found for MIR4420 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4420 Gene

Publications for MIR4420 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 60
  2. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3 60
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 60

Products for MIR4420 Gene

Sources for MIR4420 Gene

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