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Aliases for MIR433 Gene

Subcategory (RNA class) for MIR433 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR433 Gene

  • MicroRNA 433 2 3
  • MIRN433 3 6
  • Hsa-Mir-433 3
  • MiRNA433 3

External Ids for MIR433 Gene

ORGUL Members for MIR433 Gene

Previous HGNC Symbols for MIR433 Gene

  • MIRN433

Previous GeneCards Identifiers for MIR433 Gene

  • GC14P100464
  • GC14P100847
  • GC14P101348

Summaries for MIR433 Gene

Entrez Gene Summary for MIR433 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR433 Gene

MIR433 (MicroRNA 433) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR433 Gene

Genomics for MIR433 Gene

Genomic Location for MIR433 Gene

Start:
100,881,883 bp from pter
End:
100,882,006 bp from pter
Size:
124 bases
Orientation:
Plus strand

Genomic View for MIR433 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR433 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR433 Gene

No data available for Regulatory Elements for MIR433 Gene

Proteins for MIR433 Gene

Post-translational modifications for MIR433 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR433 Gene

Domains for MIR433 Gene

Gene Families for MIR433 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR433: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR433 Gene

Function for MIR433 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR433 Gene

Localization for MIR433 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR433 Gene

Pathways for MIR433 Gene

SuperPathways for MIR433 Gene

No Data Available

Interacting Proteins for MIR433 Gene

Gene Ontology (GO) - Biological Process for MIR433 Gene

None

No data available for Pathways by source for MIR433 Gene

Transcripts for MIR433 Gene

mRNA/cDNA for MIR433 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIR433

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR433 Gene

No ASD Table

Relevant External Links for MIR433 Gene

GeneLoc Exon Structure for
MIR433
ECgene alternative splicing isoforms for
MIR433

Expression for MIR433 Gene

mRNA expression in normal human tissues for MIR433 Gene

mRNA differential expression in normal tissues according to GTEx for MIR433 Gene

This gene is overexpressed in Brain - Hypothalamus (31.6) and Brain - Substantia nigra (4.6).
genes like me logo Genes that share expressions with MIR433: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for MIR433 Gene

Orthologs for MIR433 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR433 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-433 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-433 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-433 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir433 36
  • 100 (a)
OneToOne
Species with no ortholog for MIR433:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR433 Gene

ENSEMBL:
Gene Tree for MIR433 (if available)
TreeFam:
Gene Tree for MIR433 (if available)

Paralogs for MIR433 Gene

No data available for Paralogs for MIR433 Gene

Variants for MIR433 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR433 Gene

Variant ID Type Subtype PubMed ID
nsv902240 CNV Loss 21882294
nsv509549 CNV Insertion 20534489
nsv902241 CNV Loss 21882294

Relevant External Links for MIR433 Gene

HapMap Linkage Disequilibrium report
MIR433

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MIR433 Gene

Disorders for MIR433 Gene

Relevant External Links for MIR433

Genetic Association Database (GAD)
MIR433
Human Genome Epidemiology (HuGE) Navigator
MIR433
genes like me logo Genes that share disorders with MIR433: view

No data available for UniProtKB/Swiss-Prot for MIR433 Gene

Publications for MIR433 Gene

  1. FGF20 rs12720208 SNP and microRNA-433 variation: no association with Parkinson's disease in Spanish patients. (PMID: 20471450) de Mena L. … Alvarez V. (Neurosci. Lett. 2010) 3 48
  2. miR-433 is aberrantly expressed in myeloproliferative neoplasms and suppresses hematopoietic cell growth and differentiation. (PMID: 22864358) Lin X. … Licht J.D. (Leukemia 2013) 3
  3. Birth and expression evolution of mammalian microRNA genes. (PMID: 23034410) Meunier J. … Kaessmann H. (Genome Res. 2013) 3
  4. The Tumor Suppressor Roles of miR-433 and miR-127 in Gastric Cancer. (PMID: 23880861) Guo L.H. … He J.S. (Int J Mol Sci 2013) 3
  5. MicroRNA-433 negatively regulates the expression of thymidylate synthase (TYMS) responsible for 5-fluorouracil sensitivity in HeLa cells. (PMID: 23915286) Gotanda K. … Ieiri I. (BMC Cancer 2013) 3

Products for MIR433 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MIR433
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MIR433
    • Block miRNA regulation of MIR433 using miScript Target Protectors

    Sources for MIR433 Gene

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