Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR4329 Gene

Subcategory (RNA class) for MIR4329 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4329 Gene

  • MicroRNA 4329 2 3
  • AMOT 4 5
  • Hsa-Mir-4329 3
  • Angiomotin 5
  • KIAA1071 4

External Ids for MIR4329 Gene

Previous GeneCards Identifiers for MIR4329 Gene

  • GC0XU901547
  • GC0XM112018

Summaries for MIR4329 Gene

Entrez Gene Summary for MIR4329 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4329 Gene

MIR4329 (MicroRNA 4329) is an RNA Gene, and is affiliated with the miRNA class. An important paralog of this gene is AMOTL1.

UniProtKB/Swiss-Prot for MIR4329 Gene

  • Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4329 Gene

Genomics for MIR4329 Gene

Regulatory Elements for MIR4329 Gene


Promoters for MIR4329 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MIR4329 Gene

Chromosome:
X
Start:
112,774,503 bp from pter
End:
112,840,815 bp from pter
Size:
66,313 bases
Orientation:
Minus strand

Genomic View for MIR4329 Gene

Genes around MIR4329 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4329 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4329 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4329 Gene

Proteins for MIR4329 Gene

  • Protein details for MIR4329 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4VCS5-AMOT_HUMAN
    Recommended name:
    Angiomotin
    Protein Accession:
    Q4VCS5
    Secondary Accessions:
    • Q504X5
    • Q9HD27
    • Q9UPT1

    Protein attributes for MIR4329 Gene

    Size:
    1084 amino acids
    Molecular mass:
    118085 Da
    Quaternary structure:
    • Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, INADL/PATJ and PARD3/PAR3. Interacts with MAGI1. Isoform 1 interacts with angiostatin.
    • Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, INADL/PATJ and PARD3/PAR3. Interacts with MAGI1. Isoform 1 interacts with angiostatin.
    Miscellaneous:
    • Motus means motility in Latin.
    SequenceCaution:
    • Sequence=AAH94712.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for MIR4329 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR4329 Gene

Post-translational modifications for MIR4329 Gene

  • Polyubiquitinated by NEDD4, NEDD4L and ITCH, leading to proteasomal degradation.
  • Ubiquitination at Lys 94, Lys 113, and Lys 219
  • Modification sites at PhosphoSitePlus

Other Protein References for MIR4329 Gene

No data available for DME Specific Peptides for MIR4329 Gene

Domains & Families for MIR4329 Gene

Gene Families for MIR4329 Gene

Protein Domains for MIR4329 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q4VCS5

UniProtKB/Swiss-Prot:

AMOT_HUMAN :
  • The coiled coil domain interacts directly with the BAR domain of ARHGAP17.
  • Belongs to the angiomotin family.
Domain:
  • The coiled coil domain interacts directly with the BAR domain of ARHGAP17.
  • The angiostatin binding domain (871-1005) allows the binding to angiostatin.
Family:
  • Belongs to the angiomotin family.
genes like me logo Genes that share domains with MIR4329: view

No data available for Suggested Antigen Peptide Sequences for MIR4329 Gene

Function for MIR4329 Gene

Molecular function for MIR4329 Gene

UniProtKB/Swiss-Prot Function:
Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions.

Gene Ontology (GO) - Molecular Function for MIR4329 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IDA --
GO:0005515 protein binding IEA --
GO:0043532 angiostatin binding IDA --
genes like me logo Genes that share ontologies with MIR4329: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4329 Gene

Localization for MIR4329 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR4329 Gene

Cell junction, tight junction. Note=Localized on the cell surface. May act as a transmembrane protein.

Gene Ontology (GO) - Cellular Components for MIR4329 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IDA --
GO:0005829 cytosol TAS --
GO:0005884 actin filament IDA --
GO:0005923 bicellular tight junction IEA --
GO:0008180 COP9 signalosome IDA --
genes like me logo Genes that share ontologies with MIR4329: view

No data available for Subcellular locations from COMPARTMENTS for MIR4329 Gene

Pathways & Interactions for MIR4329 Gene

SuperPathways for MIR4329 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4329 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0001702 gastrulation with mouth forming second IEA --
GO:0003365 establishment of cell polarity involved in ameboidal cell migration IEA --
GO:0006935 chemotaxis IEA --
GO:0016525 negative regulation of angiogenesis IDA --
genes like me logo Genes that share ontologies with MIR4329: view

No data available for Pathways by source and SIGNOR curated interactions for MIR4329 Gene

Drugs & Compounds for MIR4329 Gene

No Compound Related Data Available

Transcripts for MIR4329 Gene

mRNA/cDNA for MIR4329 Gene

(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4329 Gene

No ASD Table

Relevant External Links for MIR4329 Gene

GeneLoc Exon Structure for
MIR4329
ECgene alternative splicing isoforms for
MIR4329

Expression for MIR4329 Gene

mRNA expression in normal human tissues for MIR4329 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4329 Gene:

MIR4329

mRNA Expression by UniProt/SwissProt for MIR4329 Gene:

Q4VCS5-AMOT_HUMAN
Tissue specificity: Expressed in placenta and skeletal muscle. Found in the endothelial cells of capillaries as well as larger vessels of the placenta.
genes like me logo Genes that share expression patterns with MIR4329: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR4329 Gene

Orthologs for MIR4329 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR4329 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AMOT 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AMOT 35
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AMOT 35
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Amot 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AMOT 35
  • 66 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AMOT 35
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves AMOT 35
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AMOT 35
  • 72 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii amot 35
  • 57 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F59C12.3 35
  • 20 (a)
OneToMany
Species where no ortholog for MIR4329 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR4329 Gene

ENSEMBL:
Gene Tree for MIR4329 (if available)
TreeFam:
Gene Tree for MIR4329 (if available)

Paralogs for MIR4329 Gene

Paralogs for MIR4329 Gene

genes like me logo Genes that share paralogs with MIR4329: view

Variants for MIR4329 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4329 Gene

Variant ID Type Subtype PubMed ID
esv3361732 OTHER inversion 20981092

Relevant External Links for MIR4329 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4329

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR4329 Gene

Disorders for MIR4329 Gene

Relevant External Links for MIR4329

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4329

No disorders were found for MIR4329 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4329 Gene

Publications for MIR4329 Gene

  1. Uncovering global SUMOylation signaling networks in a site-specific manner. (PMID: 25218447) Hendriks I.A. … Vertegaal A.C. (Nat. Struct. Mol. Biol. 2014) 4 65
  2. The Nedd4-like ubiquitin E3 ligases target angiomotin/p130 to ubiquitin-dependent degradation. (PMID: 22385262) Wang C. … Yu L. (Biochem. J. 2012) 4 65
  3. Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. (PMID: 19784364) Goff L.A. … Hart R.P. (PLoS ONE 2009) 3 65
  4. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PMID: 19413330) Gauci S. … Mohammed S. (Anal. Chem. 2009) 4 65
  5. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PMID: 17525332) Matsuoka S. … Elledge S.J. (Science 2007) 4 65

Products for MIR4329 Gene

Sources for MIR4329 Gene

Content
Loading form....