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Aliases for MIR4321 Gene

Subcategory (RNA class) for MIR4321 Gene


Quality Score for this RNA gene is


Aliases for MIR4321 Gene

  • MicroRNA 4321 2 3 5
  • Hsa-Mir-4321 3

External Ids for MIR4321 Gene

Previous GeneCards Identifiers for MIR4321 Gene

  • GC19U901368
  • GC19P002249

Summaries for MIR4321 Gene

Entrez Gene Summary for MIR4321 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4321 Gene

MIR4321 (MicroRNA 4321) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Mesodermal Commitment Pathway.

Additional gene information for MIR4321 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4321 Gene

Genomics for MIR4321 Gene

Regulatory Elements for MIR4321 Gene

Enhancers for MIR4321 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H002247 1.2 Ensembl ENCODE 0.7 +0.3 260 7.5 PKNOX1 ARID4B FEZF1 DMAP1 ZNF121 SLC30A9 GLIS2 ZNF143 MXD4 MIER2 AMH PLEKHJ1 THOP1 MIR4321 LOC105372240
GH19H002263 1.9 FANTOM5 Ensembl ENCODE dbSUPER 0.4 +13.8 13759 1.8 HDGF ATF1 FOXA2 ARNT ARID4B TCF12 ZNF766 CBX5 GATA2 ELK1 SF3A2 MIR1227 NCLN ENSG00000267283 TMPRSS9 SPPL2B LOC105372240 MIR4321
GH19H002255 1.4 Ensembl ENCODE dbSUPER 0.4 +7.4 7382 6 PKNOX1 INSM2 KLF17 FEZF1 ZNF366 SCRT2 RCOR1 ZNF391 ATF7 RUNX3 MIR1227 SF3A2 PLEKHJ1 PEAK3 JSRP1 MIR4321 LOC105372240
GH19H002266 1.2 ENCODE dbSUPER 0.4 +16.2 16155 1 HDGF PKNOX1 ATF1 ARID4B DMAP1 SLC30A9 GLIS2 ZNF143 RUNX3 SP5 JSRP1 LSM7 LOC105372240 MIR4321
GH19H002261 0.9 ENCODE dbSUPER 0.4 +11.3 11305 0.3 CTCF TRIM22 ZIC2 RAD21 ZNF592 POLR2A ZNF157 ZNF143 CREM TRIM28 PLEKHJ1 SF3A2 MIR1227 LOC105372240 MIR4321
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4321 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4321 Gene

Genomic Locations for MIR4321 Gene
80 bases
Plus strand

Genomic View for MIR4321 Gene

Genes around MIR4321 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4321 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4321 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4321 Gene

Proteins for MIR4321 Gene

Post-translational modifications for MIR4321 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4321 Gene

Domains & Families for MIR4321 Gene

Gene Families for MIR4321 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4321: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4321 Gene

Function for MIR4321 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4321 Gene

Localization for MIR4321 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4321 Gene

Pathways & Interactions for MIR4321 Gene

SuperPathways for MIR4321 Gene

SuperPathway Contained pathways
1 Mesodermal Commitment Pathway
genes like me logo Genes that share pathways with MIR4321: view

Pathways by source for MIR4321 Gene

1 BioSystems pathway for MIR4321 Gene

Interacting Proteins for MIR4321 Gene

Gene Ontology (GO) - Biological Process for MIR4321 Gene


No data available for SIGNOR curated interactions for MIR4321 Gene

Drugs & Compounds for MIR4321 Gene

No Compound Related Data Available

Transcripts for MIR4321 Gene

mRNA/cDNA for MIR4321 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4321 Gene

No ASD Table

Relevant External Links for MIR4321 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR4321 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4321 Gene:

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4321 Gene

Orthologs for MIR4321 Gene

Evolution for MIR4321 Gene

Gene Tree for MIR4321 (if available)
Gene Tree for MIR4321 (if available)

No data available for Orthologs for MIR4321 Gene

Paralogs for MIR4321 Gene

No data available for Paralogs for MIR4321 Gene

Variants for MIR4321 Gene

Sequence variations from dbSNP and Humsavar for MIR4321 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs104894666 Pathogenic 2,250,667(+) CCTCC(C/T)GAGAC nc-transcript-variant, reference, stop-gained
rs1057517993 Pathogenic 2,249,540(+) CCCCC(-/C)TGCGG upstream-variant-2KB, reference, frameshift-variant
rs185020288 Likely benign 2,249,682(+) ACGGC(A/G)GCTGG upstream-variant-2KB, reference, missense
rs1000745528 -- 2,250,279(+) CCAAA(A/G)ATTCC intron-variant, upstream-variant-2KB
rs1001352207 -- 2,249,629(+) GCCAC(C/T)TTCGG upstream-variant-2KB, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MIR4321 Gene

Variant ID Type Subtype PubMed ID
nsv833707 CNV loss 17160897
nsv578383 CNV loss 21841781
nsv578382 CNV loss 21841781
dgv6218n54 CNV loss 21841781

Relevant External Links for MIR4321 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4321 Gene

Disorders for MIR4321 Gene

Relevant External Links for MIR4321

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR4321 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4321 Gene

Publications for MIR4321 Gene

  1. Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. (PMID: 19784364) Goff LA … Hart RP (PloS one 2009) 3 60
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 60

Products for MIR4321 Gene

Sources for MIR4321 Gene

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