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Aliases for MIR431 Gene

Subcategory (RNA class) for MIR431 Gene


Quality Score for this RNA gene is


Aliases for MIR431 Gene

  • MicroRNA 431 2 3
  • MIRN431 3 6
  • Hsa-Mir-431 3
  • MiRNA431 3

External Ids for MIR431 Gene

ORGUL Members for MIR431 Gene

Previous HGNC Symbols for MIR431 Gene

  • MIRN431

Previous GeneCards Identifiers for MIR431 Gene

  • GC14P100465
  • GC14P100848
  • GC14P101347

Summaries for MIR431 Gene

Entrez Gene Summary for MIR431 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR431 Gene

MIR431 (MicroRNA 431) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR431 Gene

Genomics for MIR431 Gene

Genomic Location for MIR431 Gene

100,881,007 bp from pter
100,881,120 bp from pter
114 bases
Plus strand

Genomic View for MIR431 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR431 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR431 Gene

No data available for Regulatory Elements for MIR431 Gene

Proteins for MIR431 Gene

Post-translational modifications for MIR431 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR431 Gene

Domains for MIR431 Gene

Gene Families for MIR431 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR431: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR431 Gene

Function for MIR431 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR431 Gene

Localization for MIR431 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR431 Gene

Pathways for MIR431 Gene

SuperPathways for MIR431 Gene

No Data Available

Interacting Proteins for MIR431 Gene

Gene Ontology (GO) - Biological Process for MIR431 Gene


No data available for Pathways by source for MIR431 Gene

Transcripts for MIR431 Gene

mRNA/cDNA for MIR431 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR431 Gene

No ASD Table

Relevant External Links for MIR431 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR431 Gene

mRNA expression in normal human tissues for MIR431 Gene

mRNA differential expression in normal tissues according to GTEx for MIR431 Gene

This gene is overexpressed in Brain - Hypothalamus (39.2), Brain - Substantia nigra (5.3), and Adrenal Gland (4.6).
genes like me logo Genes that share expressions with MIR431: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIR431 Gene

Orthologs for MIR431 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR431 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-431 36
  • 94 (a)
(Canis familiaris)
Mammalia -- 36
  • 99 (a)
(Mus musculus)
Mammalia Mir431 36
  • 99 (a)
(Pan troglodytes)
Mammalia ptr-mir-431 36
  • 100 (a)
Species with no ortholog for MIR431:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR431 Gene

Gene Tree for MIR431 (if available)
Gene Tree for MIR431 (if available)

Paralogs for MIR431 Gene

No data available for Paralogs for MIR431 Gene

Variants for MIR431 Gene

Sequence variations from dbSNP and Humsavar for MIR431 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs11851174 -- 100,879,167(+) TCACC(C/T)TCACA upstream-variant-2KB
rs56262261 -- 100,879,292(+) TGTGG(A/G)GCTCA upstream-variant-2KB
rs56964729 -- 100,879,811(+) CTCGG(C/G)GGGTG upstream-variant-2KB
rs57311856 -- 100,879,699(+) CCCTC(A/C)CCCGC upstream-variant-2KB
rs59695987 -- 100,879,470(+) TGCAC(A/G)TCCCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR431 Gene

Variant ID Type Subtype PubMed ID
nsv902240 CNV Loss 21882294
nsv509549 CNV Insertion 20534489
nsv902241 CNV Loss 21882294

Relevant External Links for MIR431 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIR431 Gene

Disorders for MIR431 Gene

No disorders were found for MIR431 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for MIR431 Gene

Publications for MIR431 Gene

  1. Clustering and conservation patterns of human microRNAs. (PMID: 15891114) Altuvia Y. … Margalit H. (Nucleic Acids Res. 2005) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  3. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  4. Inhibition of cell viability by human IFN-I^ is mediated by microRNA-431. (PMID: 22293894) Tanaka T. … Suzuki N. (Int. J. Oncol. 2012) 3
  5. Differential microRNA expression in peripheral blood mononuclear cells from Graves' disease patients. (PMID: 22456620) Liu R. … Wang S. (J. Clin. Endocrinol. Metab. 2012) 3

Products for MIR431 Gene

Sources for MIR431 Gene

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