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Aliases for MIR4295 Gene

Subcategory (RNA class) for MIR4295 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4295 Gene

  • MicroRNA 4295 2 3 5
  • Hsa-Mir-4295 3

External Ids for MIR4295 Gene

Previous GeneCards Identifiers for MIR4295 Gene

  • GC10U901342
  • GC10P114393

Summaries for MIR4295 Gene

Entrez Gene Summary for MIR4295 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4295 Gene

MIR4295 (MicroRNA 4295) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4295 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4295 Gene

Genomics for MIR4295 Gene

Regulatory Elements for MIR4295 Gene

Enhancers for MIR4295 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H112643 2.2 VISTA ENCODE 0.4 +10.2 10197 0.9 FOXA2 ATF1 DNMT3B SLC30A9 SMARCC2 THAP11 KLF11 HMG20B SP5 ZHX2 ENSG00000233340 MIR4295
GH10H112631 1.2 Ensembl ENCODE 0.7 -2.2 -2232 1.8 FOXA2 ATF1 MLX ARID4B DMAP1 ATF7 MXD4 NFYC MIER2 PPARG ENSG00000233340 MIR4295 GC10M112255
GH10H112634 0.6 ENCODE 0.7 +0.4 427 0.8 PKNOX1 JUND ZSCAN4 FEZF1 FOS ZNF600 ZNF843 ENSG00000233340 MIR4295
GH10H112657 0.9 ENCODE 0.3 +24.9 24873 2.3 ELF3 PKNOX1 FOXA2 ATF1 INSM2 ARID4B KLF17 SIN3A FEZF1 RAD21 ENSG00000233340 MIR4295
GH10H112663 0.7 FANTOM5 Ensembl 0.3 +29.4 29410 0.4 JUND ACSL5 VTI1A TCF7L2 ENSG00000233340 MIR4295
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4295 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4295 Gene

Genomic Locations for MIR4295 Gene
chr10:112,634,170-112,634,254
(GRCh38/hg38)
Size:
85 bases
Orientation:
Plus strand
chr10:114,393,929-114,394,013
(GRCh37/hg19)

Genomic View for MIR4295 Gene

Genes around MIR4295 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4295 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4295 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4295 Gene

Proteins for MIR4295 Gene

Post-translational modifications for MIR4295 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4295 Gene

Domains & Families for MIR4295 Gene

Gene Families for MIR4295 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4295: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4295 Gene

Function for MIR4295 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4295 Gene

Localization for MIR4295 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4295 Gene

Pathways & Interactions for MIR4295 Gene

SuperPathways for MIR4295 Gene

No Data Available

Interacting Proteins for MIR4295 Gene

Gene Ontology (GO) - Biological Process for MIR4295 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4295 Gene

Drugs & Compounds for MIR4295 Gene

No Compound Related Data Available

Transcripts for MIR4295 Gene

mRNA/cDNA for MIR4295 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4295 Gene

No ASD Table

Relevant External Links for MIR4295 Gene

GeneLoc Exon Structure for
MIR4295
ECgene alternative splicing isoforms for
MIR4295

Expression for MIR4295 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4295 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4295 Gene:

MIR4295
genes like me logo Genes that share expression patterns with MIR4295: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4295 Gene

Orthologs for MIR4295 Gene

Evolution for MIR4295 Gene

ENSEMBL:
Gene Tree for MIR4295 (if available)
TreeFam:
Gene Tree for MIR4295 (if available)

No data available for Orthologs for MIR4295 Gene

Paralogs for MIR4295 Gene

No data available for Paralogs for MIR4295 Gene

Variants for MIR4295 Gene

Sequence variations from dbSNP and Humsavar for MIR4295 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000037904 -- 112,633,675(+) TAAAT(A/G)TGTCA intron-variant, upstream-variant-2KB
rs1000410257 -- 112,633,438(+) AATGG(A/T)AAAGT intron-variant, upstream-variant-2KB
rs1001247457 -- 112,634,536(+) ACACA(C/G/T)ACACA intron-variant, downstream-variant-500B
rs1003138920 -- 112,633,403(+) CTTAC(A/G)GGAGA intron-variant, upstream-variant-2KB
rs1003497296 -- 112,633,151(+) CTGAG(A/T)GGAGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4295 Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER inversion 18451855
nsv510234 OTHER sequence alteration 20534489

Relevant External Links for MIR4295 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4295

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4295 Gene

Disorders for MIR4295 Gene

Relevant External Links for MIR4295

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4295

No disorders were found for MIR4295 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4295 Gene

Publications for MIR4295 Gene

  1. RUNX3 is down-regulated in glioma by Myc-regulated miR-4295. (PMID: 26756701) Li X … Liu Y (Journal of cellular and molecular medicine 2016) 3 60
  2. Overexpression of deubiquitinating enzyme USP28 promoted non-small cell lung cancer growth. (PMID: 25656529) Zhang L … Qian J (Journal of cellular and molecular medicine 2015) 3 60
  3. miR-4295 promotes cell proliferation and invasion in anaplastic thyroid carcinoma via CDKN1A. (PMID: 26231799) Shao M … Ma W (Biochemical and biophysical research communications 2015) 3 60
  4. Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. (PMID: 19784364) Goff LA … Hart RP (PloS one 2009) 3 60
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 60

Products for MIR4295 Gene

Sources for MIR4295 Gene

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