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Aliases for MIR429 Gene

Subcategory (RNA class) for MIR429 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR429 Gene

  • MicroRNA 429 2 3 5
  • Hsa-Mir-429 3
  • Mir-429 3
  • MIRN429 3

External Ids for MIR429 Gene

ORGUL Members for MIR429 Gene

Previous HGNC Symbols for MIR429 Gene

  • MIRN429

Previous GeneCards Identifiers for MIR429 Gene

  • GC01P001102
  • GC01P001105
  • GC01P001109
  • GC01P001116
  • GC01P001130
  • GC01P001171
  • GC01P001175

Summaries for MIR429 Gene

Entrez Gene Summary for MIR429 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR429 Gene

MIR429 (MicroRNA 429) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR429 Gene

Genomics for MIR429 Gene

Genomic Location for MIR429 Gene

Chromosome:
1
Start:
1,169,005 bp from pter
End:
1,169,087 bp from pter
Size:
83 bases
Orientation:
Plus strand

Genomic View for MIR429 Gene

Genes around MIR429 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR429 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR429 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR429 Gene

No data available for Regulatory Elements for MIR429 Gene

Proteins for MIR429 Gene

Post-translational modifications for MIR429 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR429 Gene

Domains & Families for MIR429 Gene

Gene Families for MIR429 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR429: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR429 Gene

Function for MIR429 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR429 Gene

Localization for MIR429 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR429 Gene

Pathways & Interactions for MIR429 Gene

SuperPathways for MIR429 Gene

No Data Available

Interacting Proteins for MIR429 Gene

Gene Ontology (GO) - Biological Process for MIR429 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR429 Gene

Drugs & Compounds for MIR429 Gene

No Compound Related Data Available

Transcripts for MIR429 Gene

mRNA/cDNA for MIR429 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR429 Gene

No ASD Table

Relevant External Links for MIR429 Gene

GeneLoc Exon Structure for
MIR429
ECgene alternative splicing isoforms for
MIR429

Expression for MIR429 Gene

mRNA expression in normal human tissues for MIR429 Gene

mRNA differential expression in normal tissues according to GTEx for MIR429 Gene

This gene is overexpressed in Colon - Transverse (x9.9), Pituitary (x6.6), Stomach (x5.1), Pancreas (x4.3), and Small Intestine - Terminal Ileum (x4.2).
genes like me logo Genes that share expression patterns with MIR429: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR429 Gene

Orthologs for MIR429 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR429 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-429 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-429 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-429 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir429 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-429 36
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-429 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-429 36
  • 55 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-429a 36
  • 72 (a)
OneToMany
dre-mir-429b 36
  • 50 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-141 36
  • 55 (a)
OneToMany
Species with no ortholog for MIR429:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR429 Gene

ENSEMBL:
Gene Tree for MIR429 (if available)
TreeFam:
Gene Tree for MIR429 (if available)

Paralogs for MIR429 Gene

No data available for Paralogs for MIR429 Gene

Variants for MIR429 Gene

Sequence variations from dbSNP and Humsavar for MIR429 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs7521584 -- 1,168,578(+) GGAAC(A/G/T)TTGTC upstream-variant-2KB
rs61050058 -- 1,169,405(+) GGCTG(A/G)GACAG downstream-variant-500B
rs74045167 -- 1,169,229(+) GGGCT(C/T)TTGTG downstream-variant-500B
rs115718612 -- 1,168,462(+) GGAAG(G/T)ACAAG upstream-variant-2KB
rs115780854 -- 1,169,510(+) GCAGG(A/G)CGCAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR429 Gene

Variant ID Type Subtype PubMed ID
nsv10161 CNV Gain+Loss 18304495
nsv517709 CNV Gain+Loss 19592680
nsv428334 CNV Gain 18775914
dgv2n67 CNV Gain 20364138
nsv871547 CNV Loss 21882294
dgv10n71 CNV Loss 21882294
dgv11n71 CNV Loss 21882294
dgv12n71 CNV Loss 21882294
dgv13n71 CNV Loss 21882294
nsv470680 CNV Loss 18288195
dgv17n71 CNV Loss 21882294
dgv18n71 CNV Loss 21882294
nsv871553 CNV Loss 21882294
dgv19n71 CNV Loss 21882294
dgv20n71 CNV Loss 21882294
nsv870527 CNV Gain 21882294
nsv469848 CNV Gain 16826518
nsv509257 CNV Insertion 20534489
dgv21n71 CNV Loss 21882294
nsv871744 CNV Gain 21882294
nsv482937 CNV Loss 15286789
nsv871079 CNV Loss 21882294
dgv22n71 CNV Loss 21882294

Relevant External Links for MIR429 Gene

HapMap Linkage Disequilibrium report
MIR429

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR429 Gene

Disorders for MIR429 Gene

Relevant External Links for MIR429

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR429

No disorders were found for MIR429 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR429 Gene

Publications for MIR429 Gene

  1. Epigenetic modification of MiR-429 promotes liver tumour-initiating cell properties by targeting Rb binding protein 4. (PMID: 24572141) Li L. … Wang H. (Gut 2015) 3 67
  2. Downregulation of microRNA-429 inhibits cell proliferation by targeting p27Kip1 in human prostate cancer cells. (PMID: 25351256) Ouyang Y. … Zhang H. (Mol Med Rep 2015) 3
  3. miR-429 inhibits migration and invasion of breast cancer cells in vitro. (PMID: 25405387) Ye Z.B. … Yu S.J. (Int. J. Oncol. 2015) 3
  4. The hypoxia-inducible miR-429 regulates hypoxia-inducible factor-1I+ expression in human endothelial cells through a negative feedback loop. (PMID: 25550463) Bartoszewska S. … Bartoszewski R. (FASEB J. 2015) 3
  5. miR-200a, miR-200b and miR-429 are onco-miRs that target the PTEN gene in endometrioid endometrial carcinoma. (PMID: 25750291) Yoneyama K. … Takeshita T. (Anticancer Res. 2015) 3

Products for MIR429 Gene

Sources for MIR429 Gene

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