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Aliases for MIR4289 Gene

Subcategory (RNA class) for MIR4289 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR4289 Gene

  • MicroRNA 4289 2 3 5
  • Hsa-Mir-4289 3

External Ids for MIR4289 Gene

Previous GeneCards Identifiers for MIR4289 Gene

  • GC09U901494
  • GC09M091360

Summaries for MIR4289 Gene

Entrez Gene Summary for MIR4289 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4289 Gene

MIR4289 (MicroRNA 4289) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4289 Gene

Genomics for MIR4289 Gene

Regulatory Elements for MIR4289 Gene

Enhancers for MIR4289 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F088744 1.6 FANTOM5 Ensembl ENCODE 0.8 -1.4 -1361 5.3 ARNT CREB3L1 ARID4B SIN3A FEZF1 YY1 ZNF143 ZNF207 FOS MXD4 S1PR3 MIR4289 GC09M088841
GH09F088742 0.7 Ensembl ENCODE 0.8 +3.1 3084 1.1 CEBPB PRDM1 TCF7L2 MIR4289 PIR52315
GH09F088773 1.5 FANTOM5 Ensembl ENCODE 0.3 -30.4 -30368 5.1 TBP HDAC1 PKNOX1 INSM2 SIN3A FEZF1 RAD21 GATA2 FOS SMARCC1 CDK20 MIR4289 GC09M088841
GH09F088733 0.9 Ensembl ENCODE 0.4 +11.8 11831 1.8 JUN JUNB FEZF1 ATF2 POLR2A SMARCA4 FOXP2 FOS MIR4289 PIR52315
GH09F088731 0.9 Ensembl ENCODE 0.4 +13.5 13455 1.3 STAT1 ZNF740 HLF ZNF384 NR3C1 NFIL3 GLIS1 CEBPA NR2F6 MIR4289 PIR52315
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4289 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4289 Gene

Chromosome:
9
Start:
88,745,836 bp from pter
End:
88,745,905 bp from pter
Size:
70 bases
Orientation:
Minus strand

Genomic View for MIR4289 Gene

Genes around MIR4289 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4289 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4289 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4289 Gene

ORGUL Member Location for MIR4289 Gene

ORGUL Member Location for MIR4289 gene

Proteins for MIR4289 Gene

Post-translational modifications for MIR4289 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4289 Gene

Domains & Families for MIR4289 Gene

Gene Families for MIR4289 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4289: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4289 Gene

Function for MIR4289 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4289 Gene

Localization for MIR4289 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4289 Gene

Pathways & Interactions for MIR4289 Gene

SuperPathways for MIR4289 Gene

No Data Available

Interacting Proteins for MIR4289 Gene

Gene Ontology (GO) - Biological Process for MIR4289 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4289 Gene

Transcripts for MIR4289 Gene

mRNA/cDNA for MIR4289 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4289 Gene

No ASD Table

Relevant External Links for MIR4289 Gene

GeneLoc Exon Structure for
MIR4289
ECgene alternative splicing isoforms for
MIR4289

Expression for MIR4289 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4289 Gene:

MIR4289
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4289 Gene

Orthologs for MIR4289 Gene

Evolution for MIR4289 Gene

ENSEMBL:
Gene Tree for MIR4289 (if available)
TreeFam:
Gene Tree for MIR4289 (if available)

No data available for Orthologs for MIR4289 Gene

Paralogs for MIR4289 Gene

No data available for Paralogs for MIR4289 Gene

Variants for MIR4289 Gene

Sequence variations from dbSNP and Humsavar for MIR4289 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs115171102 -- 88,746,335(+) ATGCA(C/T)CCACC upstream-variant-2KB
rs115517393 -- 88,745,470(+) CAGGG(C/T)GGAGC downstream-variant-500B
rs117415653 -- 88,746,934(+) CCCGG(A/G)GCTCT upstream-variant-2KB
rs117829057 -- 88,746,583(+) TAGGA(A/G)GCCAG upstream-variant-2KB
rs138610348 -- 88,745,638(+) TGTAT(A/G)TCAGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR4289 Gene

Variant ID Type Subtype PubMed ID
nsv614824 CNV loss 21841781
nsv831650 CNV gain 17160897

Relevant External Links for MIR4289 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4289

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4289 Gene

Disorders for MIR4289 Gene

Relevant External Links for MIR4289

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4289

No disorders were found for MIR4289 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4289 Gene

Publications for MIR4289 Gene

  1. Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. (PMID: 19784364) Goff L.A. … Hart R.P. (PLoS ONE 2009) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4289 Gene

Sources for MIR4289 Gene

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