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Aliases for MIR4286 Gene

Subcategory (RNA class) for MIR4286 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4286 Gene

  • MicroRNA 4286 2 3 5
  • Hsa-Mir-4286 3
  • Mir-4286 3

External Ids for MIR4286 Gene

Previous GeneCards Identifiers for MIR4286 Gene

  • GC08U901409
  • GC08P009454
  • GC08P010524

Summaries for MIR4286 Gene

Entrez Gene Summary for MIR4286 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4286 Gene

MIR4286 (MicroRNA 4286) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4286 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4286 Gene

Genomics for MIR4286 Gene

Regulatory Elements for MIR4286 Gene

Enhancers for MIR4286 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H010652 1.2 Ensembl ENCODE 0.4 -13.1 -13089 3.8 HDGF PKNOX1 FEZF1 ZNF2 GLIS2 FOS TSHZ1 ZNF488 SMARCA4 ZSCAN16 LOC101929290 PINX1 PRSS52P LOC105379241 RNA5SP252 LINC00529 ENSG00000249316 LINC00208 LOC100420053 RP1L1
GH08H010627 1 Ensembl ENCODE 0.3 -36.6 -36558 5 HDAC1 IRF2 SUZ12 JUN ZSCAN4 ZBTB40 ZNF644 POLR2A STAT2 RFX1 LOC105379241 ENSG00000269954 ENSG00000269918 ENSG00000272505 PRSS51 XKR6 ENSG00000255310 MIR4286 LOC105379237
GH08H010636 0.9 Ensembl ENCODE 0.3 -30.3 -30252 1.3 HDAC1 SOX6 RNF2 ZMYM3 NR2F2 KLF16 FOXK2 FOXP2 MYC ENSG00000269954 PRSS51 ENSG00000255310 MIR4286 LOC105379237
GH08H010587 0.8 ENCODE 0.2 -79.5 -79473 0.2 CTCF ARNT ARID4B EBF1 ZNF2 RAD21 CC2D1A SMC3 ZNF143 ZNF600 SOX7 LOC101929229 PINX1 RP1L1 LOC102723313 LOC105379237 MIR4286
GH08H010590 0.8 ENCODE 0.2 -76.6 -76633 0.2 CTCF RB1 ZNF2 RAD21 CC2D1A ZFHX2 GLIS2 EGR1 PATZ1 SMC3 LOC105379237 MIR4286
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4286 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4286 Gene

Genomic Locations for MIR4286 Gene
chr8:10,666,978-10,667,070
(GRCh38/hg38)
Size:
93 bases
Orientation:
Plus strand
chr8:10,524,488-10,524,580
(GRCh37/hg19)

Genomic View for MIR4286 Gene

Genes around MIR4286 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4286 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4286 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4286 Gene

Proteins for MIR4286 Gene

Post-translational modifications for MIR4286 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4286 Gene

Domains & Families for MIR4286 Gene

Gene Families for MIR4286 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4286: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4286 Gene

Function for MIR4286 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4286 Gene

Localization for MIR4286 Gene

Gene Ontology (GO) - Cellular Components for MIR4286 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR4286: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR4286 Gene

Pathways & Interactions for MIR4286 Gene

SuperPathways for MIR4286 Gene

No Data Available

Interacting Proteins for MIR4286 Gene

Gene Ontology (GO) - Biological Process for MIR4286 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4286 Gene

Drugs & Compounds for MIR4286 Gene

No Compound Related Data Available

Transcripts for MIR4286 Gene

mRNA/cDNA for MIR4286 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4286 Gene

No ASD Table

Relevant External Links for MIR4286 Gene

GeneLoc Exon Structure for
MIR4286
ECgene alternative splicing isoforms for
MIR4286

Expression for MIR4286 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4286 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4286 Gene:

MIR4286
genes like me logo Genes that share expression patterns with MIR4286: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4286 Gene

Orthologs for MIR4286 Gene

Evolution for MIR4286 Gene

ENSEMBL:
Gene Tree for MIR4286 (if available)
TreeFam:
Gene Tree for MIR4286 (if available)

No data available for Orthologs for MIR4286 Gene

Paralogs for MIR4286 Gene

No data available for Paralogs for MIR4286 Gene

Variants for MIR4286 Gene

Sequence variations from dbSNP and Humsavar for MIR4286 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000042429 -- 10,665,533(+) AACCT(A/C)TAAGC upstream-variant-2KB
rs1000349601 -- 10,667,432(+) CTCCT(C/T)CACAA downstream-variant-500B
rs1002373099 -- 10,665,446(+) TTGTC(C/T)TTTAC upstream-variant-2KB
rs1002399456 -- 10,665,643(+) ACTTA(C/T)AAATT upstream-variant-2KB
rs1004376666 -- 10,665,804(+) GATAA(C/T)GTGGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4286 Gene

Variant ID Type Subtype PubMed ID
nsv610267 CNV gain 21841781
nsv1030934 CNV gain 25217958
nsv1025557 CNV gain 25217958

Relevant External Links for MIR4286 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4286

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4286 Gene

Disorders for MIR4286 Gene

Relevant External Links for MIR4286

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4286

No disorders were found for MIR4286 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4286 Gene

Publications for MIR4286 Gene

  1. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 60
  2. Antiproliferative and Pro-Apoptotic Effects of MiR-4286 Inhibition in Melanoma Cells. (PMID: 28005927) Komina A … Ruksha T (PloS one 2016) 3 60
  3. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 60
  4. Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. (PMID: 19784364) Goff LA … Hart RP (PloS one 2009) 3 60
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 60

Products for MIR4286 Gene

Sources for MIR4286 Gene

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