Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR4285 Gene

Subcategory (RNA class) for MIR4285 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4285 Gene

  • MicroRNA 4285 2 3 5
  • Hsa-Mir-4285 3

External Ids for MIR4285 Gene

Previous GeneCards Identifiers for MIR4285 Gene

  • GC07U902929
  • GC07P096526
  • GC07P101937

Summaries for MIR4285 Gene

Entrez Gene Summary for MIR4285 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4285 Gene

MIR4285 (MicroRNA 4285) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4285 Gene

Genomics for MIR4285 Gene

Regulatory Elements for MIR4285 Gene

Enhancers for MIR4285 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F102291 1 Ensembl ENCODE 0.8 -1.5 -1468 1.1 TBL1XR1 EBF1 ZIC2 YY1 RELA ZNF121 ZFHX2 POLR2A EGR1 EED MIR4285 SH2B2
GH07F102294 0.9 Ensembl ENCODE 0.8 +2.5 2496 1.2 ZNF146 ZNF280D NRF1 EBF1 ZNF121 ZNF341 IKZF1 ZNF239 EED ZBTB33 ENSG00000239486 SH2B2 POLR2J2 MIR4285 ENSG00000170409
GH07F102292 0.8 Ensembl 0.8 +0.2 198 1.4 ZMYM3 ZIC2 RAD21 YY1 ZNF316 ZFHX2 POLR2A EED ZNF143 HNF4G SH2B2 MIR4285 ENSG00000170409
GH07F102284 1.5 FANTOM5 ENCODE 0.4 -6.4 -6381 5.4 ATF1 PKNOX1 ZNF133 ARID4B SIN3A GLI4 YBX1 ZNF48 ZNF2 YY1 SH2B2 CUX1 ORAI2 ENSG00000239486 POLR2J ARMC10 COL26A1 PRKRIP1 POLR2J3 ALKBH4
GH07F102301 1.3 Ensembl ENCODE 0.4 +11.5 11537 7.2 HDGF ATF1 PKNOX1 ARNT SIN3A ARID4B YY1 ZNF121 GLIS2 ZNF143 PRKRIP1 ENSG00000239486 ENSG00000213385 POLR2J2 SH2B2 MIR4285 ENSG00000170409
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4285 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4285 Gene

Chromosome:
7
Start:
102,293,103 bp from pter
End:
102,293,187 bp from pter
Size:
85 bases
Orientation:
Plus strand

Genomic View for MIR4285 Gene

Genes around MIR4285 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4285 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4285 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4285 Gene

Proteins for MIR4285 Gene

Post-translational modifications for MIR4285 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4285 Gene

Domains & Families for MIR4285 Gene

Gene Families for MIR4285 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4285: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4285 Gene

Function for MIR4285 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4285 Gene

Localization for MIR4285 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4285 Gene

Pathways & Interactions for MIR4285 Gene

SuperPathways for MIR4285 Gene

No Data Available

Interacting Proteins for MIR4285 Gene

Gene Ontology (GO) - Biological Process for MIR4285 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4285 Gene

Transcripts for MIR4285 Gene

mRNA/cDNA for MIR4285 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4285 Gene

No ASD Table

Relevant External Links for MIR4285 Gene

GeneLoc Exon Structure for
MIR4285
ECgene alternative splicing isoforms for
MIR4285

Expression for MIR4285 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4285 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4285 Gene:

MIR4285
genes like me logo Genes that share expression patterns with MIR4285: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4285 Gene

Orthologs for MIR4285 Gene

Evolution for MIR4285 Gene

ENSEMBL:
Gene Tree for MIR4285 (if available)
TreeFam:
Gene Tree for MIR4285 (if available)

No data available for Orthologs for MIR4285 Gene

Paralogs for MIR4285 Gene

No data available for Paralogs for MIR4285 Gene

Variants for MIR4285 Gene

Sequence variations from dbSNP and Humsavar for MIR4285 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10228306 -- 102,293,525(+) GCCTA(A/G)AAAAA intron-variant, downstream-variant-500B
rs111360636 -- 102,292,087(+) TGAGA(A/G)GGCAT intron-variant, upstream-variant-2KB
rs111888377 -- 102,291,366(+) CAAGC(A/G)ATGCT intron-variant, upstream-variant-2KB
rs112983886 -- 102,292,409(+) ACCTA(C/T)AGTCC intron-variant, upstream-variant-2KB
rs116480479 -- 102,291,861(+) TGGGA(A/G)TCACT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4285 Gene

Variant ID Type Subtype PubMed ID
nsv949918 CNV deletion 24416366
nsv831082 CNV gain 17160897
nsv509218 CNV insertion 20534489
nsv428182 CNV gain 18775914
esv2759548 CNV gain 17122850
dgv6538n100 CNV gain 25217958
dgv11539n54 CNV loss 21841781

Relevant External Links for MIR4285 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4285

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4285 Gene

Disorders for MIR4285 Gene

Relevant External Links for MIR4285

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4285

No disorders were found for MIR4285 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4285 Gene

Publications for MIR4285 Gene

  1. Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. (PMID: 19784364) Goff L.A. … Hart R.P. (PLoS ONE 2009) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4285 Gene

Sources for MIR4285 Gene

Content
Loading form....