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Aliases for MIR4281 Gene

Subcategory (RNA class) for MIR4281 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR4281 Gene

  • MicroRNA 4281 2 3 5
  • Hsa-Mir-4281 3

External Ids for MIR4281 Gene

Previous GeneCards Identifiers for MIR4281 Gene

  • GC05U901444
  • GC05M170980
  • GC05M176056

Summaries for MIR4281 Gene

Entrez Gene Summary for MIR4281 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4281 Gene

MIR4281 (MicroRNA 4281) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4281 Gene

Genomics for MIR4281 Gene

Regulatory Elements for MIR4281 Gene

Enhancers for MIR4281 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G176628 0.9 Ensembl 0.7 -0.2 -161 2.3 PKNOX1 SIN3A GLIS2 EGR1 SCRT2 SP3 SP5 TSHZ1 ZNF623 ZFP69B TSPAN17 GPRIN1 SNCB MIR4281
GH05G176619 0.8 ENCODE 0.4 +10.1 10106 0.2 HDAC1 CTCF RB1 RAD21 GATA2 EGR1 SMC3 CREM EGR2 EZH2 HK3 GPRIN1 MIR4281
GH05G176620 0.7 ENCODE 0.4 +8.8 8826 0.2 MAZ L3MBTL2 SUZ12 NRF1 ETV1 BHLHE40 SP2 JUND GLIS2 ZNF341 HK3 GPRIN1 MIR4281
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4281 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4281 Gene

Chromosome:
5
Start:
176,629,439 bp from pter
End:
176,629,500 bp from pter
Size:
62 bases
Orientation:
Minus strand

Genomic View for MIR4281 Gene

Genes around MIR4281 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4281 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4281 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4281 Gene

ORGUL Member Location for MIR4281 Gene

ORGUL Member Location for MIR4281 gene

Proteins for MIR4281 Gene

Post-translational modifications for MIR4281 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4281 Gene

Domains & Families for MIR4281 Gene

Gene Families for MIR4281 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4281: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4281 Gene

Function for MIR4281 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4281 Gene

Localization for MIR4281 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4281 Gene

Pathways & Interactions for MIR4281 Gene

SuperPathways for MIR4281 Gene

No Data Available

Interacting Proteins for MIR4281 Gene

Gene Ontology (GO) - Biological Process for MIR4281 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4281 Gene

Drugs & Compounds for MIR4281 Gene

No Compound Related Data Available

Transcripts for MIR4281 Gene

mRNA/cDNA for MIR4281 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4281 Gene

No ASD Table

Relevant External Links for MIR4281 Gene

GeneLoc Exon Structure for
MIR4281
ECgene alternative splicing isoforms for
MIR4281

Expression for MIR4281 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4281 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4281 Gene:

MIR4281
genes like me logo Genes that share expression patterns with MIR4281: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4281 Gene

Orthologs for MIR4281 Gene

Evolution for MIR4281 Gene

ENSEMBL:
Gene Tree for MIR4281 (if available)
TreeFam:
Gene Tree for MIR4281 (if available)

No data available for Orthologs for MIR4281 Gene

Paralogs for MIR4281 Gene

No data available for Paralogs for MIR4281 Gene

Variants for MIR4281 Gene

Sequence variations from dbSNP and Humsavar for MIR4281 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000994975 -- 176,630,524(+) GCGCT(A/G)CGGCA upstream-variant-2KB, utr-variant-5-prime
rs1001048750 -- 176,630,335(+) CGCGG(C/G)GGCTC upstream-variant-2KB, utr-variant-5-prime
rs1002134149 -- 176,630,238(+) TCTCC(A/G)TCCTC intron-variant, upstream-variant-2KB
rs1003086669 -- 176,629,186(+) TGTTA(C/T)GACAT intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1003798072 -- 176,629,864(+) GAAAC(C/T)TGGGG intron-variant, upstream-variant-2KB, splice-acceptor-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MIR4281 Gene

Variant ID Type Subtype PubMed ID
nsv600346 CNV loss 21841781

Relevant External Links for MIR4281 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4281

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4281 Gene

Disorders for MIR4281 Gene

Relevant External Links for MIR4281

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4281

No disorders were found for MIR4281 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4281 Gene

Publications for MIR4281 Gene

  1. Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. (PMID: 19784364) Goff L.A. … Hart R.P. (PLoS ONE 2009) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4281 Gene

Sources for MIR4281 Gene

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