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Aliases for MIR4280 Gene

Subcategory (RNA class) for MIR4280 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR4280 Gene

  • MicroRNA 4280 2 3
  • Hsa-Mir-4280 3

External Ids for MIR4280 Gene

Previous GeneCards Identifiers for MIR4280 Gene

  • GC05U901424
  • GC05M086410

Summaries for MIR4280 Gene

Entrez Gene Summary for MIR4280 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4280 Gene

MIR4280 (MicroRNA 4280) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4280 Gene

Genomics for MIR4280 Gene

Genomic Location for MIR4280 Gene

Start:
87,114,879 bp from pter
End:
87,114,954 bp from pter
Size:
76 bases
Orientation:
Minus strand

Genomic View for MIR4280 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR4280 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4280 Gene

ORGUL Member Location for MIR4280 Gene

ORGUL Member Location for MIR4280 gene

No data available for Regulatory Elements for MIR4280 Gene

Proteins for MIR4280 Gene

Post-translational modifications for MIR4280 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4280 Gene

Domains for MIR4280 Gene

Gene Families for MIR4280 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4280: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4280 Gene

Function for MIR4280 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR4280 Gene

Localization for MIR4280 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4280 Gene

Pathways for MIR4280 Gene

SuperPathways for MIR4280 Gene

No Data Available

Interacting Proteins for MIR4280 Gene

Gene Ontology (GO) - Biological Process for MIR4280 Gene

None

No data available for Pathways by source for MIR4280 Gene

Transcripts for MIR4280 Gene

mRNA/cDNA for MIR4280 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4280 Gene

No ASD Table

Relevant External Links for MIR4280 Gene

GeneLoc Exon Structure for
MIR4280
ECgene alternative splicing isoforms for
MIR4280

Expression for MIR4280 Gene

No Expression Related Data Available

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIR4280 Gene

Orthologs for MIR4280 Gene

Evolution for MIR4280 Gene

ENSEMBL:
Gene Tree for MIR4280 (if available)
TreeFam:
Gene Tree for MIR4280 (if available)

No data available for Orthologs for MIR4280 Gene

Paralogs for MIR4280 Gene

No data available for Paralogs for MIR4280 Gene

Variants for MIR4280 Gene

Sequence variations from dbSNP and Humsavar for MIR4280 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs1004988 -- 87,115,181(-) CTGCA(A/C)CTGAG upstream-variant-2KB
rs2410740 -- 87,116,662(+) ATGGC(A/G)AGTTT upstream-variant-2KB
rs2544668 -- 87,116,241(-) CAGGC(C/G)AGTTA upstream-variant-2KB
rs2544669 -- 87,115,877(-) GGTGG(C/T)GTGTG upstream-variant-2KB
rs4270729 -- 87,116,079(+) AAAAC(C/T)GTAAA upstream-variant-2KB

Relevant External Links for MIR4280 Gene

HapMap Linkage Disequilibrium report
MIR4280

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MIR4280 Gene

Disorders for MIR4280 Gene

No disorders were found for MIR4280 Gene.

No data available for UniProtKB/Swiss-Prot for MIR4280 Gene

Publications for MIR4280 Gene

  1. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  2. Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. (PMID: 19784364) Goff L.A. … Hart R.P. (PLoS ONE 2009) 3

Products for MIR4280 Gene

Sources for MIR4280 Gene

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