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Aliases for MIR4273 Gene

Subcategory (RNA class) for MIR4273 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4273 Gene

  • MicroRNA 4273 2 3 5
  • Hsa-Mir-4273 3

External Ids for MIR4273 Gene

Previous GeneCards Identifiers for MIR4273 Gene

  • GC03U901568

Summaries for MIR4273 Gene

Entrez Gene Summary for MIR4273 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4273 Gene

MIR4273 (MicroRNA 4273) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4273 Gene

Genomics for MIR4273 Gene

Regulatory Elements for MIR4273 Gene

Enhancers for MIR4273 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F075781 0.2 ENCODE 0.2 +43.4 43365 0.9 SP1 MTA2 NFYB JUNB TBX21 SPI1 LINC00960 RPL23AP49 FAM86DP ZNF717 MIR4273
GH03F075784 0.2 ENCODE 0.2 +47.1 47104 1.7 TBP CREB3L1 ZNF76 SIN3A ZBTB40 YY1 ZNF121 ZNF143 ZNF207 CREM LINC00960 RPL23AP49 ZNF717 MIR4273
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR4273 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4273 Gene

Chromosome:
3
Start:
75,738,280 bp from pter
End:
75,738,363 bp from pter
Size:
84 bases
Orientation:
Plus strand

Genomic View for MIR4273 Gene

Genes around MIR4273 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4273 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4273 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4273 Gene

Proteins for MIR4273 Gene

Post-translational modifications for MIR4273 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4273 Gene

Domains & Families for MIR4273 Gene

Gene Families for MIR4273 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4273: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4273 Gene

Function for MIR4273 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4273 Gene

Localization for MIR4273 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4273 Gene

Pathways & Interactions for MIR4273 Gene

SuperPathways for MIR4273 Gene

No Data Available

Interacting Proteins for MIR4273 Gene

Gene Ontology (GO) - Biological Process for MIR4273 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4273 Gene

Transcripts for MIR4273 Gene

mRNA/cDNA for MIR4273 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4273 Gene

No ASD Table

Relevant External Links for MIR4273 Gene

GeneLoc Exon Structure for
MIR4273
ECgene alternative splicing isoforms for
MIR4273

Expression for MIR4273 Gene

mRNA expression in normal human tissues for MIR4273 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4273 Gene:

MIR4273
genes like me logo Genes that share expression patterns with MIR4273: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4273 Gene

Orthologs for MIR4273 Gene

Evolution for MIR4273 Gene

ENSEMBL:
Gene Tree for MIR4273 (if available)
TreeFam:
Gene Tree for MIR4273 (if available)

No data available for Orthologs for MIR4273 Gene

Paralogs for MIR4273 Gene

No data available for Paralogs for MIR4273 Gene

Variants for MIR4273 Gene

Sequence variations from dbSNP and Humsavar for MIR4273 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs193921040 Uncertain significance 75,738,395(-) CATAC(C/G)TCACA intron-variant, downstream-variant-500B, reference, missense
rs10442977 -- 75,738,265(+) CATTA(C/T)ATTCA intron-variant, upstream-variant-2KB, reference, missense
rs11122676 -- 75,737,681(+) ACATA(C/T)GTAAG intron-variant, upstream-variant-2KB, reference, missense
rs111230396 -- 75,736,920(+) CCTGC(A/C)TCAGC intron-variant, upstream-variant-2KB, reference, missense
rs111315075 -- 75,738,211(+) GAGTT(A/C)TCTGA intron-variant, upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MIR4273 Gene

Variant ID Type Subtype PubMed ID
dgv2543n106 CNV deletion 24896259
dgv2722e59 CNV duplication 20981092
dgv4773n100 CNV gain 25217958
dgv4790n100 CNV gain 25217958
dgv4794n100 CNV gain 25217958
dgv4795n100 CNV gain 25217958
dgv812n67 CNV gain 20364138
dgv8385n54 CNV gain 21841781
esv2422315 CNV deletion 17116639
esv2436311 CNV gain 19546169
esv26581 CNV gain+loss 19812545
esv2725476 CNV deletion 23290073
esv2725478 CNV deletion 23290073
esv2725479 CNV deletion 23290073
esv2725481 CNV deletion 23290073
esv2725482 CNV deletion 23290073
esv2759157 CNV gain+loss 17122850
esv2763755 CNV gain+loss 21179565
esv2836125 CNV deletion 24192839
esv33470 CNV loss 17666407
esv3434335 CNV duplication 20981092
esv3893725 CNV gain 25118596
esv9630 CNV loss 19470904
nsv1008600 CNV gain 25217958
nsv1008795 CNV loss 25217958
nsv1012185 CNV loss 25217958
nsv1015074 CNV gain 25217958
nsv10283 CNV gain+loss 18304495
nsv428418 CNV loss 18775914
nsv471427 CNV gain 19718026
nsv513053 CNV loss 21212237
nsv529016 CNV gain 19592680
nsv590725 CNV loss 21841781
nsv821408 CNV duplication 20802225
nsv822138 CNV gain 20364138
nsv822140 CNV loss 20364138
nsv954891 CNV duplication 24416366
nsv956263 CNV deletion 24416366

Relevant External Links for MIR4273 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4273

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4273 Gene

Disorders for MIR4273 Gene

Relevant External Links for MIR4273

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4273

No disorders were found for MIR4273 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4273 Gene

Publications for MIR4273 Gene

  1. Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. (PMID: 19784364) Goff L.A. … Hart R.P. (PLoS ONE 2009) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4273 Gene

Sources for MIR4273 Gene

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