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Aliases for MIR4270 Gene

Subcategory (RNA class) for MIR4270 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR4270 Gene

  • MicroRNA 4270 2 3 5
  • Hsa-Mir-4270 3

External Ids for MIR4270 Gene

Previous GeneCards Identifiers for MIR4270 Gene

  • GC03U901678
  • GC03M015537

Summaries for MIR4270 Gene

Entrez Gene Summary for MIR4270 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4270 Gene

MIR4270 (MicroRNA 4270) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4270 Gene

Genomics for MIR4270 Gene

Regulatory Elements for MIR4270 Gene

Enhancers for MIR4270 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G015497 0.8 ENCODE dbSUPER 0.7 -2.2 -2172 1.3 SMARCA4 POLR2A GLIS1 REST ZIC2 EAF1 EAF1-AS1 HACL1 COLQ LOC105376964 MIR4270
GH03G015467 0.8 ENCODE 0.3 +28.0 27974 2.1 PKNOX1 BACH1 BMI1 EBF1 ARID3A RELB IKZF2 MTA2 RNF2 BHLHE40 EAF1-AS1 RNU6-1024P MIR4270
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4270 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4270 Gene

Chromosome:
3
Start:
15,496,239 bp from pter
End:
15,496,308 bp from pter
Size:
70 bases
Orientation:
Minus strand

Genomic View for MIR4270 Gene

Genes around MIR4270 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4270 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4270 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4270 Gene

ORGUL Member Location for MIR4270 Gene

ORGUL Member Location for MIR4270 gene

Proteins for MIR4270 Gene

Post-translational modifications for MIR4270 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4270 Gene

Domains & Families for MIR4270 Gene

Gene Families for MIR4270 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4270: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4270 Gene

Function for MIR4270 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4270 Gene

Localization for MIR4270 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4270 Gene

Pathways & Interactions for MIR4270 Gene

SuperPathways for MIR4270 Gene

No Data Available

Interacting Proteins for MIR4270 Gene

Gene Ontology (GO) - Biological Process for MIR4270 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4270 Gene

Drugs & Compounds for MIR4270 Gene

No Compound Related Data Available

Transcripts for MIR4270 Gene

mRNA/cDNA for MIR4270 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4270 Gene

No ASD Table

Relevant External Links for MIR4270 Gene

GeneLoc Exon Structure for
MIR4270
ECgene alternative splicing isoforms for
MIR4270

Expression for MIR4270 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4270 Gene:

MIR4270
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4270 Gene

Orthologs for MIR4270 Gene

Evolution for MIR4270 Gene

ENSEMBL:
Gene Tree for MIR4270 (if available)
TreeFam:
Gene Tree for MIR4270 (if available)

No data available for Orthologs for MIR4270 Gene

Paralogs for MIR4270 Gene

No data available for Paralogs for MIR4270 Gene

Variants for MIR4270 Gene

Sequence variations from dbSNP and Humsavar for MIR4270 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1001313097 -- 15,498,203(+) AGGTA(C/T)TTGTG intron-variant, upstream-variant-2KB
rs1003014422 -- 15,497,129(+) ACCTC(C/T)GCCTC intron-variant, upstream-variant-2KB
rs1003393284 -- 15,496,649(+) GGAAC(G/T)TCAGG intron-variant, upstream-variant-2KB
rs1003593860 -- 15,496,822(+) GAGAC(G/T)TTCTC intron-variant, upstream-variant-2KB
rs1004453997 -- 15,496,497(+) TGTGT(A/C)TGAGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4270 Gene

Variant ID Type Subtype PubMed ID
nsv834621 CNV gain 17160897
nsv834622 CNV gain 17160897

Relevant External Links for MIR4270 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4270

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4270 Gene

Disorders for MIR4270 Gene

Relevant External Links for MIR4270

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4270

No disorders were found for MIR4270 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4270 Gene

Publications for MIR4270 Gene

  1. Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. (PMID: 19784364) Goff L.A. … Hart R.P. (PLoS ONE 2009) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4270 Gene

Sources for MIR4270 Gene

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