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Aliases for MIR4269 Gene

Subcategory (RNA class) for MIR4269 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4269 Gene

  • MicroRNA 4269 2 3 5
  • Hsa-Mir-4269 3

External Ids for MIR4269 Gene

Previous GeneCards Identifiers for MIR4269 Gene

  • GC02U902184
  • GC02P240227

Summaries for MIR4269 Gene

Entrez Gene Summary for MIR4269 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4269 Gene

MIR4269 (MicroRNA 4269) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4269 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4269 Gene

Genomics for MIR4269 Gene

GeneHancer (GH) Regulatory Elements for MIR4269 Gene

Promoters and enhancers for MIR4269 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I239306 Enhancer 0.2 dbSUPER 562.5 +1.5 1508 1.5 MIR4269 LOC101928111 HDAC4 GC02P239327
GH02I239272 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.9 -28.5 -28450 8.4 PKNOX1 ATF1 FOXA2 SIN3A IRF4 TCF12 POLR2B ZNF766 GATA2 ARID2 HDAC4 MIR4269 LOC101928111 GC02M239271 MGC16025
GH02I239293 Enhancer 1.4 Ensembl ENCODE dbSUPER 13.1 -5.9 -5852 12 HDGF PKNOX1 ATF1 FOXA2 MLX ZFP64 ARID4B IRF4 ZNF48 ETS1 GC02M239271 MIR4269 HDAC4
GH02I239307 Enhancer 1 Ensembl ENCODE dbSUPER 17.6 +5.5 5547 6.5 MEIS2 PKNOX1 NFIA NFIC ZFHX2 ZBTB33 RCOR1 CHD2 MIR4269 LOC101928111 HDAC4 GC02P239327
GH02I239399 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 6.8 +95.2 95233 4.4 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ZFP64 ARID4B SIN3A FEZF1 LOC101928111 HDAC4 MIR4269 MIR2467
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR4269 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4269 Gene

Genomic Locations for MIR4269 Gene
chr2:239,305,462-239,305,545
(GRCh38/hg38)
Size:
84 bases
Orientation:
Plus strand
chr2:240,227,157-240,227,240
(GRCh37/hg19)

Genomic View for MIR4269 Gene

Genes around MIR4269 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4269 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4269 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4269 Gene

Proteins for MIR4269 Gene

Post-translational modifications for MIR4269 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4269 Gene

Domains & Families for MIR4269 Gene

Gene Families for MIR4269 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4269: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4269 Gene

Function for MIR4269 Gene

Phenotypes From GWAS Catalog for MIR4269 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4269 Gene

Localization for MIR4269 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4269 Gene

Pathways & Interactions for MIR4269 Gene

SuperPathways for MIR4269 Gene

No Data Available

Interacting Proteins for MIR4269 Gene

Gene Ontology (GO) - Biological Process for MIR4269 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4269 Gene

Drugs & Compounds for MIR4269 Gene

No Compound Related Data Available

Transcripts for MIR4269 Gene

mRNA/cDNA for MIR4269 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4269 Gene

No ASD Table

Relevant External Links for MIR4269 Gene

GeneLoc Exon Structure for
MIR4269
ECgene alternative splicing isoforms for
MIR4269

Expression for MIR4269 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4269 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4269 Gene:

MIR4269
genes like me logo Genes that share expression patterns with MIR4269: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4269 Gene

Orthologs for MIR4269 Gene

Evolution for MIR4269 Gene

ENSEMBL:
Gene Tree for MIR4269 (if available)
TreeFam:
Gene Tree for MIR4269 (if available)

No data available for Orthologs for MIR4269 Gene

Paralogs for MIR4269 Gene

No data available for Paralogs for MIR4269 Gene

Variants for MIR4269 Gene

Sequence variations from dbSNP and Humsavar for MIR4269 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000953300 -- 239,305,237(+) G/T upstream_transcript_variant
rs1005426836 -- 239,304,572(+) A/T upstream_transcript_variant
rs1006015183 -- 239,303,486(+) C/T upstream_transcript_variant
rs1006482263 -- 239,305,878(+) T/C downstream_transcript_variant
rs1008819788 -- 239,304,909(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4269 Gene

Variant ID Type Subtype PubMed ID
nsv834582 CNV loss 17160897

Additional Variant Information for MIR4269 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4269

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4269 Gene

Disorders for MIR4269 Gene

Additional Disease Information for MIR4269

No disorders were found for MIR4269 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4269 Gene

Publications for MIR4269 Gene

  1. TEAD1/4 exerts oncogenic role and is negatively regulated by miR-4269 in gastric tumorigenesis. (PMID: 28759040) Zhou Y … To KF (Oncogene 2017) 3 58
  2. Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. (PMID: 19784364) Goff LA … Hart RP (PloS one 2009) 3 58
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR4269 Gene

Sources for MIR4269 Gene

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