Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR4260 Gene

Subcategory (RNA class) for MIR4260 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4260 Gene

  • MicroRNA 4260 2 3
  • LAMB3 4 5
  • Epiligrin Subunit Bata 4
  • Laminin-5 Subunit Beta 4
  • Laminin Subunit Beta 3 5
  • Kalinin Subunit Beta 4
  • Nicein Subunit Beta 4
  • Laminin B1k Chain 4
  • Kalinin B1 Chain 4
  • Hsa-Mir-4260 3
  • LAMNB1 4

External Ids for MIR4260 Gene

Previous GeneCards Identifiers for MIR4260 Gene

  • GC01U902889
  • GC01M209796

Summaries for MIR4260 Gene

Entrez Gene Summary for MIR4260 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4260 Gene

MIR4260 (MicroRNA 4260) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR4260 include Epidermolysis Bullosa, Junctional, Herlitz Type and Hypoplastic Amelogenesis Imperfecta. An important paralog of this gene is LAMB2.

UniProtKB/Swiss-Prot for MIR4260 Gene

  • Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4260 Gene

Genomics for MIR4260 Gene

Regulatory Elements for MIR4260 Gene

Enhancers for MIR4260 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MIR4260 on UCSC Golden Path with GeneCards custom track

Promoters for MIR4260 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIR4260 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4260 Gene

Chromosome:
1
Start:
209,614,870 bp from pter
End:
209,652,466 bp from pter
Size:
37,597 bases
Orientation:
Minus strand

Genomic View for MIR4260 Gene

Genes around MIR4260 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4260 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4260 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4260 Gene

ORGUL Member Location for MIR4260 Gene

ORGUL Member Location for MIR4260 gene

Proteins for MIR4260 Gene

  • Protein details for MIR4260 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13751-LAMB3_HUMAN
    Recommended name:
    Laminin subunit beta-3
    Protein Accession:
    Q13751
    Secondary Accessions:
    • D3DT88
    • O14947
    • Q14733
    • Q9UJK4
    • Q9UJL1

    Protein attributes for MIR4260 Gene

    Size:
    1172 amino acids
    Molecular mass:
    129572 Da
    Quaternary structure:
    • Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Beta-3 is a subunit of laminin-5 (laminin-332 or epiligrin/kalinin/nicein). Interacts with ECM1.
    • Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Beta-3 is a subunit of laminin-5 (laminin-332 or epiligrin/kalinin/nicein). Interacts with ECM1.

neXtProt entry for MIR4260 Gene

Post-translational modifications for MIR4260 Gene

  • Glycosylation at Asn 220, Asn 604, Ser 712, and Asn 810
  • Modification sites at PhosphoSitePlus

Other Protein References for MIR4260 Gene

No data available for DME Specific Peptides for MIR4260 Gene

Domains & Families for MIR4260 Gene

Gene Families for MIR4260 Gene

Protein Domains for MIR4260 Gene

Graphical View of Domain Structure for InterPro Entry

Q13751

UniProtKB/Swiss-Prot:

LAMB3_HUMAN :
  • The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
Domain:
  • The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
  • Domain VI is globular.
  • Contains 6 laminin EGF-like domains.
  • Contains 1 laminin N-terminal domain.
genes like me logo Genes that share domains with MIR4260: view

No data available for Suggested Antigen Peptide Sequences for MIR4260 Gene

Function for MIR4260 Gene

Molecular function for MIR4260 Gene

UniProtKB/Swiss-Prot Function:
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

Gene Ontology (GO) - Molecular Function for MIR4260 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI --
GO:0032403 protein complex binding IEA --
genes like me logo Genes that share ontologies with MIR4260: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4260 Gene

Localization for MIR4260 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR4260 Gene

Secreted, extracellular space, extracellular matrix, basement membrane.

Gene Ontology (GO) - Cellular Components for MIR4260 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005604 basement membrane IEA --
GO:0005610 laminin-5 complex IEA --
genes like me logo Genes that share ontologies with MIR4260: view

No data available for Subcellular locations from COMPARTMENTS for MIR4260 Gene

Pathways & Interactions for MIR4260 Gene

SuperPathways for MIR4260 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4260 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0008544 epidermis development TAS --
GO:0022617 extracellular matrix disassembly TAS --
GO:0030198 extracellular matrix organization TAS --
GO:0031581 hemidesmosome assembly TAS --
genes like me logo Genes that share ontologies with MIR4260: view

No data available for Pathways by source and SIGNOR curated interactions for MIR4260 Gene

Drugs & Compounds for MIR4260 Gene

No Compound Related Data Available

Transcripts for MIR4260 Gene

mRNA/cDNA for MIR4260 Gene

(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4260 Gene

No ASD Table

Relevant External Links for MIR4260 Gene

GeneLoc Exon Structure for
MIR4260
ECgene alternative splicing isoforms for
MIR4260

Expression for MIR4260 Gene

mRNA expression in normal human tissues for MIR4260 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4260 Gene:

MIR4260

mRNA Expression by UniProt/SwissProt for MIR4260 Gene:

Q13751-LAMB3_HUMAN
Tissue specificity: Found in the basement membranes (major component).
genes like me logo Genes that share expression patterns with MIR4260: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR4260 Gene

Orthologs for MIR4260 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR4260 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LAMB3 35
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LAMB3 35
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LAMB3 35
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lamb3 35
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LAMB3 35
  • 60 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LAMB3 35
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves LAMB3 35
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LAMB3 35
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LAMB3 35
  • 30 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5480 35
  • 33 (a)
OneToOne
Species where no ortholog for MIR4260 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR4260 Gene

ENSEMBL:
Gene Tree for MIR4260 (if available)
TreeFam:
Gene Tree for MIR4260 (if available)

Paralogs for MIR4260 Gene

Paralogs for MIR4260 Gene

genes like me logo Genes that share paralogs with MIR4260: view

Variants for MIR4260 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4260 Gene

Variant ID Type Subtype PubMed ID
dgv143e212 CNV loss 25503493

Relevant External Links for MIR4260 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4260

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR4260 Gene

Disorders for MIR4260 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR4260 Gene - From: GeneCards

Disorder Aliases PubMed IDs
epidermolysis bullosa, junctional, herlitz type
  • junctional epidermolysis bullosa, herlitz type
hypoplastic amelogenesis imperfecta
  • amelogenesis imperfecta type 1
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

LAMB3_HUMAN
  • Amelogenesis imperfecta 1A (AI1A) [MIM:104530]: A form of amelogenesis imperfecta, a disorder characterized by defective enamel formation. The enamel may be hypoplastic, hypomineralized or both, and affected teeth may be discoloured, sensitive or prone to disintegration. {ECO:0000269 PubMed:23632796, ECO:0000269 PubMed:23958762}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Epidermolysis bullosa, junctional, Herlitz type (H-JEB) [MIM:226700]: An infantile and lethal form of junctional epidermolysis bullosa, a group of blistering skin diseases characterized by tissue separation which occurs within the dermo-epidermal basement In the Herlitz type, death occurs usually within the first six months of life. Occasionally, children survive to teens. It is marked by bullous lesions at birth and extensive denudation of skin and mucous membranes that may be hemorrhagic. {ECO:0000269 PubMed:7550237}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Generalized atrophic benign epidermolysis bullosa (GABEB) [MIM:226650]: A non-lethal, adult form of junctional epidermolysis bullosa characterized by life-long blistering of the skin, associated with hair and tooth abnormalities. {ECO:0000269 PubMed:17476356, ECO:0000269 PubMed:9767254}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MIR4260

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4260
genes like me logo Genes that share disorders with MIR4260: view

No data available for Genatlas for MIR4260 Gene

Publications for MIR4260 Gene

  1. Whole-exome sequencing, without prior linkage, identifies a mutation in LAMB3 as a cause of dominant hypoplastic amelogenesis imperfecta. (PMID: 23632796) Poulter J.A. … Mighell A.J. (Eur. J. Hum. Genet. 2014) 4 65
  2. LAMB3 mutations causing autosomal-dominant amelogenesis imperfecta. (PMID: 23958762) Kim J.W. … Hu J.C. (J. Dent. Res. 2013) 4 65
  3. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 65
  4. Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. (PMID: 19784364) Goff L.A. … Hart R.P. (PLoS ONE 2009) 3 65
  5. ECM1 interacts with fibulin-3 and the beta 3 chain of laminin 332 through its serum albumin subdomain-like 2 domain. (PMID: 19275936) Sercu S. … Merregaert J. (Matrix Biol. 2009) 4 65

Products for MIR4260 Gene

Sources for MIR4260 Gene

Content