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Aliases for MIR4259 Gene

Subcategory (RNA class) for MIR4259 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR4259 Gene

  • MicroRNA 4259 2 3 5
  • Hsa-Mir-4259 3

External Ids for MIR4259 Gene

Previous GeneCards Identifiers for MIR4259 Gene

  • GC01U902901
  • GC01M159872

Summaries for MIR4259 Gene

Entrez Gene Summary for MIR4259 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4259 Gene

MIR4259 (MicroRNA 4259) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4259 Gene

Genomics for MIR4259 Gene

Regulatory Elements for MIR4259 Gene

Enhancers for MIR4259 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F159898 0.6 Ensembl ENCODE 0.8 0.0 -41 4.1 SREBF2 BMI1 RAD21 SCRT2 FOS EGR2 ZNF217 PBX2 FOXJ2 ZNF24 ENSG00000272668 C1orf204 VSIG8 CFAP45 MIR4259
GH01F159895 0.5 Ensembl 0.8 +3.7 3679 1.6 CTCF ZNF316 JUND NCOR1 ZIC2 EMSY ZBTB7A IGSF9 TAGLN2 FCRL6 DUSP23 ENSG00000212161 PIGM MIR4259 ENSG00000256029
GH01F159888 1.2 FANTOM5 Ensembl ENCODE 0.4 +9.7 9679 3.2 HDGF TBP ATF1 KLF17 PTRF SIN3A ZNF2 RAD21 RFX5 GLIS2 ENSG00000272668 VSIG8 SLAMF8 C1orf204 FCRL6 ENSG00000212161 IGSF9 DUSP23 PIGM SLAMF9
GH01F159879 1.3 FANTOM5 Ensembl ENCODE 0.3 +19.0 18979 4.2 PKNOX1 SIN3A FOS DEK ZNF518A MAFF SMARCA4 GLIS1 STAT3 KDM1A ENSG00000228606 ENSG00000272668 SLAMF8 VSIG8 SLAMF9 C1orf204 TAGLN2 COPA ENSG00000256029 MIR4259
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR4259 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4259 Gene

Chromosome:
1
Start:
159,899,979 bp from pter
End:
159,900,079 bp from pter
Size:
101 bases
Orientation:
Minus strand

Genomic View for MIR4259 Gene

Genes around MIR4259 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4259 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4259 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4259 Gene

ORGUL Member Location for MIR4259 Gene

ORGUL Member Location for MIR4259 gene

Proteins for MIR4259 Gene

Post-translational modifications for MIR4259 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4259 Gene

Domains & Families for MIR4259 Gene

Gene Families for MIR4259 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4259: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4259 Gene

Function for MIR4259 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4259 Gene

Localization for MIR4259 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4259 Gene

Pathways & Interactions for MIR4259 Gene

SuperPathways for MIR4259 Gene

No Data Available

Interacting Proteins for MIR4259 Gene

Gene Ontology (GO) - Biological Process for MIR4259 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4259 Gene

Transcripts for MIR4259 Gene

mRNA/cDNA for MIR4259 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4259 Gene

No ASD Table

Relevant External Links for MIR4259 Gene

GeneLoc Exon Structure for
MIR4259
ECgene alternative splicing isoforms for
MIR4259

Expression for MIR4259 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4259 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4259 Gene:

MIR4259
genes like me logo Genes that share expression patterns with MIR4259: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4259 Gene

Orthologs for MIR4259 Gene

Evolution for MIR4259 Gene

ENSEMBL:
Gene Tree for MIR4259 (if available)
TreeFam:
Gene Tree for MIR4259 (if available)

No data available for Orthologs for MIR4259 Gene

Paralogs for MIR4259 Gene

No data available for Paralogs for MIR4259 Gene

Variants for MIR4259 Gene

Sequence variations from dbSNP and Humsavar for MIR4259 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs111819507 -- 159,900,983(+) CCAGT(-/GCTGATTA)GCTGA upstream-variant-2KB
rs112059504 -- 159,899,811(+) TCCAC(A/G)GAGGC intron-variant, downstream-variant-500B
rs112976698 -- 159,900,158(+) AGGCC(C/T)TAGTG upstream-variant-2KB
rs114667238 -- 159,901,577(+) AATCT(A/G)TTCTT upstream-variant-2KB
rs118133691 -- 159,901,191(+) ACAGG(C/T)TTCAC upstream-variant-2KB

Relevant External Links for MIR4259 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4259

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR4259 Gene

Disorders for MIR4259 Gene

Relevant External Links for MIR4259

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4259

No disorders were found for MIR4259 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4259 Gene

Publications for MIR4259 Gene

  1. Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. (PMID: 19784364) Goff L.A. … Hart R.P. (PLoS ONE 2009) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4259 Gene

Sources for MIR4259 Gene

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