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Aliases for MIR4258 Gene

Subcategory (RNA class) for MIR4258 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4258 Gene

  • MicroRNA 4258 2 3 5
  • Hsa-Mir-4258 3

External Ids for MIR4258 Gene

Previous GeneCards Identifiers for MIR4258 Gene

  • GC01U902916
  • GC01P154948

Summaries for MIR4258 Gene

Entrez Gene Summary for MIR4258 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4258 Gene

MIR4258 (MicroRNA 4258) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR4258 include prostate cancer susceptibility.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4258 Gene

Genomics for MIR4258 Gene

Regulatory Elements for MIR4258 Gene

Promoters for MIR4258 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIR4258 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4258 Gene

Chromosome:
1
Start:
154,975,693 bp from pter
End:
154,975,783 bp from pter
Size:
91 bases
Orientation:
Plus strand

Genomic View for MIR4258 Gene

Genes around MIR4258 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4258 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4258 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4258 Gene

Proteins for MIR4258 Gene

Post-translational modifications for MIR4258 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4258 Gene

Domains & Families for MIR4258 Gene

Gene Families for MIR4258 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4258: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4258 Gene

Function for MIR4258 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4258 Gene

Localization for MIR4258 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4258 Gene

Pathways & Interactions for MIR4258 Gene

SuperPathways for MIR4258 Gene

No Data Available

Interacting Proteins for MIR4258 Gene

Gene Ontology (GO) - Biological Process for MIR4258 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4258 Gene

Drugs & Compounds for MIR4258 Gene

No Compound Related Data Available

Transcripts for MIR4258 Gene

mRNA/cDNA for MIR4258 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4258 Gene

No ASD Table

Relevant External Links for MIR4258 Gene

GeneLoc Exon Structure for
MIR4258
ECgene alternative splicing isoforms for
MIR4258

Expression for MIR4258 Gene

mRNA expression in normal human tissues for MIR4258 Gene

genes like me logo Genes that share expression patterns with MIR4258: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR4258 Gene

Orthologs for MIR4258 Gene

Evolution for MIR4258 Gene

ENSEMBL:
Gene Tree for MIR4258 (if available)
TreeFam:
Gene Tree for MIR4258 (if available)

No data available for Orthologs for MIR4258 Gene

Paralogs for MIR4258 Gene

No data available for Paralogs for MIR4258 Gene

Variants for MIR4258 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4258 Gene

Variant ID Type Subtype PubMed ID
nsv509502 CNV Insertion 20534489
nsv872453 CNV Loss 21882294
nsv872454 CNV Loss 21882294

Relevant External Links for MIR4258 Gene

HapMap Linkage Disequilibrium report
MIR4258

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR4258 Gene

Disorders for MIR4258 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR4258 Gene - From: GeneCards

Disorder Aliases PubMed IDs
prostate cancer susceptibility
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR4258

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4258
genes like me logo Genes that share disorders with MIR4258: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR4258 Gene

Publications for MIR4258 Gene

  1. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles R.A. … Easton D.F. (Nat. Genet. 2013) 3 67
  2. Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. (PMID: 19784364) Goff L.A. … Hart R.P. (PLoS ONE 2009) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3

Products for MIR4258 Gene

Sources for MIR4258 Gene

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