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Aliases for MIR4258 Gene

Subcategory (RNA class) for MIR4258 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4258 Gene

  • MicroRNA 4258 2 3 5
  • Hsa-Mir-4258 3

External Ids for MIR4258 Gene

Previous GeneCards Identifiers for MIR4258 Gene

  • GC01U902916
  • GC01P154948

Summaries for MIR4258 Gene

Entrez Gene Summary for MIR4258 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4258 Gene

MIR4258 (MicroRNA 4258) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4258 Gene

Genomics for MIR4258 Gene

Regulatory Elements for MIR4258 Gene

Enhancers for MIR4258 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F154998 1.6 FANTOM5 ENCODE 16.4 +28.8 28759 11.3 MLX CREB3L1 ZFP64 FEZF1 YBX1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 KIAA0907 THBS3 ENSG00000271267 RUSC1-AS1 ASH1L-AS1 MSTO2P KRTCAP2 ZBTB7B LOC101928120 EFNA4
GH01F154177 1.6 FANTOM5 ENCODE 16.2 -794.8 -794813 6.8 HDGF PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 NUP210L ENSG00000224784 MIR4258 PYGO2 UBAP2L ENSG00000272654 LOC101928120 C1orf189 ENSG00000201129 HAX1
GH01F154606 1.5 FANTOM5 ENCODE 16.2 -367.2 -367229 4.1 HDGF WRNIP1 ARID4B SIN3A YBX1 FEZF1 ZNF2 YY1 ZNF207 ZNF263 ENSG00000271267 CHRNB2 MIR4258 DAP3P1 RUSC1-AS1 NUP210L CHTOP DPM3 EFNA4 UBE2Q1
GH01F154351 1.4 Ensembl ENCODE 16.2 -622.4 -622393 3.8 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 CHTOP RUSC1-AS1 INTS3 SLC27A3 THBS3 EFNA4 ENSG00000272030 ENSG00000224784 MIR4258 KRTCAP2
GH01F155242 1.2 ENCODE 16.2 +268.6 268550 2.9 CREB3L1 YBX1 FEZF1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 SP3 TBX21 KIAA0907 ENSG00000271267 MSTO2P RUSC1-AS1 THBS3 ASH1L PYGO2 LOC101928120 KRTCAP2 GBA
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4258 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4258 Gene

Chromosome:
1
Start:
154,975,693 bp from pter
End:
154,975,783 bp from pter
Size:
91 bases
Orientation:
Plus strand

Genomic View for MIR4258 Gene

Genes around MIR4258 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4258 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4258 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4258 Gene

Proteins for MIR4258 Gene

Post-translational modifications for MIR4258 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4258 Gene

Domains & Families for MIR4258 Gene

Gene Families for MIR4258 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4258: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4258 Gene

Function for MIR4258 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4258 Gene

Localization for MIR4258 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4258 Gene

Pathways & Interactions for MIR4258 Gene

SuperPathways for MIR4258 Gene

No Data Available

Interacting Proteins for MIR4258 Gene

Gene Ontology (GO) - Biological Process for MIR4258 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4258 Gene

Transcripts for MIR4258 Gene

mRNA/cDNA for MIR4258 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4258 Gene

No ASD Table

Relevant External Links for MIR4258 Gene

GeneLoc Exon Structure for
MIR4258
ECgene alternative splicing isoforms for
MIR4258

Expression for MIR4258 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4258 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4258 Gene:

MIR4258
genes like me logo Genes that share expression patterns with MIR4258: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4258 Gene

Orthologs for MIR4258 Gene

Evolution for MIR4258 Gene

ENSEMBL:
Gene Tree for MIR4258 (if available)
TreeFam:
Gene Tree for MIR4258 (if available)

No data available for Orthologs for MIR4258 Gene

Paralogs for MIR4258 Gene

No data available for Paralogs for MIR4258 Gene

Variants for MIR4258 Gene

Sequence variations from dbSNP and Humsavar for MIR4258 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs111464741 -- 154,973,963(+) GGCGG(A/T)GTTTC intron-variant, upstream-variant-2KB
rs112083152 -- 154,975,167(+) GAGAA(C/T)GTAGC intron-variant, upstream-variant-2KB
rs112342667 -- 154,975,027(+) AGAGG(A/G)GAGAG intron-variant, upstream-variant-2KB
rs11264293 -- 154,974,041(+) TCCAG(A/G)AAAAC intron-variant, upstream-variant-2KB
rs112752440 -- 154,975,725(+) AGGCT(C/G)ACCTC intron-variant, nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4258 Gene

Variant ID Type Subtype PubMed ID
nsv509502 CNV insertion 20534489

Relevant External Links for MIR4258 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4258

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4258 Gene

Disorders for MIR4258 Gene

Relevant External Links for MIR4258

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4258

No disorders were found for MIR4258 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4258 Gene

Publications for MIR4258 Gene

  1. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles R.A. … Easton D.F. (Nat. Genet. 2013) 3 64
  2. Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. (PMID: 19784364) Goff L.A. … Hart R.P. (PLoS ONE 2009) 3 64
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4258 Gene

Sources for MIR4258 Gene

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