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Aliases for MIR4253 Gene

Subcategory (RNA class) for MIR4253 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR4253 Gene

  • MicroRNA 4253 2 3 5
  • Hsa-Mir-4253 3

External Ids for MIR4253 Gene

Previous GeneCards Identifiers for MIR4253 Gene

  • GC01U902923
  • GC01M023189

Summaries for MIR4253 Gene

Entrez Gene Summary for MIR4253 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4253 Gene

MIR4253 (MicroRNA 4253) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4253 Gene

Genomics for MIR4253 Gene

Regulatory Elements for MIR4253 Gene

Enhancers for MIR4253 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F022860 1.3 Ensembl ENCODE 0.8 +1.6 1556 2.2 MLX ARID4B SIN3A DMAP1 ZNF48 YY1 FOS ZNF263 NFYC MIER2 MIR4253 ENSG00000225952
GH01F022875 0.9 Ensembl ENCODE 0.4 -13.4 -13351 1.8 BCOR SMARCA5 ZNF16 JUND ZFHX2 SMARCA4 KDM1A EGR2 ENSG00000225952 MIR4253 GC01P022918
GH01F022851 0.9 FANTOM5 0.4 +11.5 11527 0.2 CREB3L1 NFRKB ZEB1 ZNF335 EGR2 ZNF263 ZBTB11 ZEB2 ZNF843 TFDP1 C1QA C1QB C1QC ENSG00000225952 MIR4253
GH01F022872 0.6 ENCODE 0.4 -10.2 -10189 1.3 RFX1 ZNF362 NFYC ZMYM3 MAX USF2 RAD51 NFYB MIR4253 GC01P022918
GH01F022850 0.5 Ensembl 0.4 +12.7 12726 0.2 CEBPB CEBPG TAF7 ZNF652 ENSG00000225952 MIR4253
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR4253 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR4253 Gene

Chromosome:
1
Start:
22,863,159 bp from pter
End:
22,863,226 bp from pter
Size:
68 bases
Orientation:
Minus strand

Genomic View for MIR4253 Gene

Genes around MIR4253 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4253 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4253 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4253 Gene

ORGUL Member Location for MIR4253 Gene

ORGUL Member Location for MIR4253 gene

Proteins for MIR4253 Gene

Post-translational modifications for MIR4253 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4253 Gene

Domains & Families for MIR4253 Gene

Gene Families for MIR4253 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4253: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4253 Gene

Function for MIR4253 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4253 Gene

Localization for MIR4253 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR4253 Gene

Pathways & Interactions for MIR4253 Gene

SuperPathways for MIR4253 Gene

No Data Available

Interacting Proteins for MIR4253 Gene

Gene Ontology (GO) - Biological Process for MIR4253 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4253 Gene

Transcripts for MIR4253 Gene

mRNA/cDNA for MIR4253 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4253 Gene

No ASD Table

Relevant External Links for MIR4253 Gene

GeneLoc Exon Structure for
MIR4253
ECgene alternative splicing isoforms for
MIR4253

Expression for MIR4253 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4253 Gene:

MIR4253
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR4253 Gene

Orthologs for MIR4253 Gene

Evolution for MIR4253 Gene

ENSEMBL:
Gene Tree for MIR4253 (if available)
TreeFam:
Gene Tree for MIR4253 (if available)

No data available for Orthologs for MIR4253 Gene

Paralogs for MIR4253 Gene

No data available for Paralogs for MIR4253 Gene

Variants for MIR4253 Gene

Sequence variations from dbSNP and Humsavar for MIR4253 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs35882952 Pathogenic 22,863,060(+) TCAAG(C/G/T)CCAAC downstream-variant-500B, reference, missense
rs10917320 -- 22,863,592(+) GAGAA(C/T)GCAGC intron-variant, upstream-variant-2KB
rs111569109 -- 22,863,222(+) CGATG(C/G)CTGGC intron-variant, nc-transcript-variant
rs112449884 -- 22,864,632(+) CCAAA(C/T)GCAAA intron-variant, upstream-variant-2KB
rs112908109 -- 22,864,608(+) AATAG(A/G)TACTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR4253 Gene

Variant ID Type Subtype PubMed ID
nsv528926 CNV loss 19592680
nsv469829 CNV loss 16826518

Relevant External Links for MIR4253 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4253

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4253 Gene

Disorders for MIR4253 Gene

Relevant External Links for MIR4253

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR4253

No disorders were found for MIR4253 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4253 Gene

Publications for MIR4253 Gene

  1. Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. (PMID: 19784364) Goff L.A. … Hart R.P. (PLoS ONE 2009) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR4253 Gene

Sources for MIR4253 Gene

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