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Aliases for MIR425 Gene

Subcategory (RNA class) for MIR425 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR425 Gene

  • MicroRNA 425 2 3 5
  • Hsa-Mir-425 3
  • Mir-425 3
  • MIRN425 3

External Ids for MIR425 Gene

Previous HGNC Symbols for MIR425 Gene

  • MIRN425

Previous GeneCards Identifiers for MIR425 Gene

  • GC03M049049
  • GC03M049053
  • GC03M049057
  • GC03M049070
  • GC03M049079
  • GC03M049084
  • GC03M049089
  • GC03M049095
  • GC03M049101

Summaries for MIR425 Gene

Entrez Gene Summary for MIR425 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR425 Gene

MIR425 (MicroRNA 425) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR425 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR425

Additional gene information for MIR425 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR425 Gene

Genomics for MIR425 Gene

Regulatory Elements for MIR425 Gene

Enhancers for MIR425 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H049338 1.9 FANTOM5 ENCODE dbSUPER 10.5 -325.8 -325816 14 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 AMT QRICH1 ATRIP ENSG00000235236 WDR6 RBM6 BSN-AS1 DALRD3 RBM5 IP6K2
GH03H048769 0.4 ENCODE 9.6 +249.9 249867 1 RUNX3 PRDM1 PRKAR2A-AS1 PRKAR2A NCKIPSD COL7A1 PFKFB4 UCN2 QARS QRICH1 IMPDH2 MIR191
GH03H048971 0.2 dbSUPER 10.9 +48.2 48189 1 WDR6 NDUFAF3 MIR425 MIR191 DALRD3 IMPDH2 QRICH1 QARS NICN1 PIR49221
GH03H049016 1.4 ENCODE dbSUPER 0.7 0.0 -27 6 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A FEZF1 ZNF2 ZBTB7B YY1 WDR6 ENSG00000235236 NICN1 FCF1P2 QRICH1 RBM6 ZNF589 ENSG00000223343 P4HTM AMT
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR425 on UCSC Golden Path with GeneCards custom track

Promoters for MIR425 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000303947 734 201 BCOR MLLT1
ENSR00000152177 1834 1201 ATF1 ZNF133 ARID4B SIN3A ZNF121 GLIS2 ELK1 KLF7 ATF7 RUNX3

Genomic Location for MIR425 Gene

Chromosome:
3
Start:
49,020,148 bp from pter
End:
49,020,234 bp from pter
Size:
87 bases
Orientation:
Minus strand

Genomic View for MIR425 Gene

Genes around MIR425 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR425 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR425 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR425 Gene

ORGUL Member Location for MIR425 Gene

ORGUL Member Location for MIR425 gene

Proteins for MIR425 Gene

Post-translational modifications for MIR425 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR425 Gene

Domains & Families for MIR425 Gene

Gene Families for MIR425 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR425: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR425 Gene

Function for MIR425 Gene

Phenotypes From GWAS Catalog for MIR425 Gene

Gene Ontology (GO) - Molecular Function for MIR425 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 27185878
genes like me logo Genes that share ontologies with MIR425: view

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR425
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR425 Gene

Localization for MIR425 Gene

Gene Ontology (GO) - Cellular Components for MIR425 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR425: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR425 Gene

Pathways & Interactions for MIR425 Gene

SuperPathways for MIR425 Gene

No Data Available

Interacting Proteins for MIR425 Gene

Gene Ontology (GO) - Biological Process for MIR425 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IGI 27185878
genes like me logo Genes that share ontologies with MIR425: view

No data available for Pathways by source and SIGNOR curated interactions for MIR425 Gene

Drugs & Compounds for MIR425 Gene

No Compound Related Data Available

Transcripts for MIR425 Gene

fRNAdb Secondary structures for MIR425 Gene

  • FR402885

mRNA/cDNA for MIR425 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR425
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR425 Gene

No ASD Table

Relevant External Links for MIR425 Gene

GeneLoc Exon Structure for
MIR425
ECgene alternative splicing isoforms for
MIR425

Expression for MIR425 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR425 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR425 Gene:

MIR425
genes like me logo Genes that share expression patterns with MIR425: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR425 Gene

Orthologs for MIR425 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR425 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-425 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-425 34
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir425 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-425 34
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-425 34
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-425 34
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-425 34
  • 74 (a)
OneToOne
Species where no ortholog for MIR425 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR425 Gene

ENSEMBL:
Gene Tree for MIR425 (if available)
TreeFam:
Gene Tree for MIR425 (if available)

Paralogs for MIR425 Gene

No data available for Paralogs for MIR425 Gene

Variants for MIR425 Gene

Sequence variations from dbSNP and Humsavar for MIR425 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs121918136 Pathogenic 49,022,146(+) AGCCA(C/T)GGCCA intron-variant, upstream-variant-2KB, reference, missense
rs567032648 Likely pathogenic 49,022,175(+) GCTTG(C/G/T)ACCGA intron-variant, upstream-variant-2KB, reference, missense
rs573066357 Uncertain significance 49,021,904(+) TCCCC(C/T)GGGAC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs74601553 Uncertain significance 49,022,018(+) GGGCC(C/G)GTCGA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs75749590 Uncertain significance 49,022,019(+) GGCCG(C/G)TCGAG intron-variant, upstream-variant-2KB, utr-variant-5-prime

Relevant External Links for MIR425 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR425

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR425 Gene

Disorders for MIR425 Gene

Relevant External Links for MIR425

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR425

No disorders were found for MIR425 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR425 Gene

Publications for MIR425 Gene

  1. Clustering and conservation patterns of human microRNAs. (PMID: 15891114) Altuvia Y … Margalit H (Nucleic acids research 2005) 1 3 60
  2. A pancreatic islet-specific microRNA regulates insulin secretion. (PMID: 15538371) Poy MN … Stoffel M (Nature 2004) 1 3 60
  3. A panel of microRNA signature in serum for colorectal cancer diagnosis. (PMID: 28177881) Zhu M … Liu P (Oncotarget 2017) 3 60
  4. MicoRNA-425-5p is a potential prognostic biomarker for cervical cancer. (PMID: 27166306) Sun L … Mu N (Annals of clinical biochemistry 2017) 3 60
  5. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 60

Products for MIR425 Gene

Sources for MIR425 Gene

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