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Aliases for MIR425 Gene

Subcategory (RNA class) for MIR425 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR425 Gene

  • MicroRNA 425 2 3 5
  • Hsa-Mir-425 3
  • Mir-425 3
  • MIRN425 3

External Ids for MIR425 Gene

Previous HGNC Symbols for MIR425 Gene

  • MIRN425

Previous GeneCards Identifiers for MIR425 Gene

  • GC03M049049
  • GC03M049053
  • GC03M049057
  • GC03M049070
  • GC03M049079
  • GC03M049084
  • GC03M049089
  • GC03M049095

Summaries for MIR425 Gene

Entrez Gene Summary for MIR425 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR425 Gene

MIR425 (MicroRNA 425) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR425 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR425

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR425 Gene

Genomics for MIR425 Gene

Regulatory Elements for MIR425 Gene

Enhancers for MIR425 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G049338 1.9 FANTOM5 ENCODE dbSUPER 10.5 -325.8 -325816 14.7 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC AMT QRICH1 IMPDH2 DALRD3 RHOA WDR6 NICN1 USP4 ENSG00000230454 RHOA-IT1
GH03G048971 0.5 dbSUPER 10.9 +48.2 48189 1.1 GLIS1 ZNF394 PRDM10 ZIC2 WDR6 MIR191 MIR425 NDUFAF3 DALRD3 IMPDH2 QRICH1 QARS NICN1 PIR49221
GH03G048769 0.4 ENCODE 9.6 +249.9 249867 1.3 PRDM1 PRKAR2A PRKAR2A-AS1 NCKIPSD COL7A1 PFKFB4 UCN2 QARS QRICH1 DALRD3 MIR191
GH03G049016 1.4 ENCODE dbSUPER 0.7 0.0 -27 6.8 CREB3L1 AGO1 ZFP64 FEZF1 YY1 ZNF143 SP3 NFYC ZFP41 ZNF610 WDR6 AMT ENSG00000223343 QRICH1 CCDC71 P4HTM ENSG00000235236 ARIH2 QARS ARIH2OS
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR425 on UCSC Golden Path with GeneCards custom track

Promoters for MIR425 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000303947 734 201 BCOR MLLT1 REST
ENSR00000303946 -1366 2801 MLX CREB3L1 AGO1 ZFP64 FEZF1 YY1 ZNF143 SP3 NFYC ZFP41
ENSR00000152177 1834 1201 ATF1 AGO1 ZNF133 ARID4B SIN3A ZNF48 ZNF121 GLIS2 ELK1 FOS

Genomic Location for MIR425 Gene

Chromosome:
3
Start:
49,020,148 bp from pter
End:
49,020,234 bp from pter
Size:
87 bases
Orientation:
Minus strand

Genomic View for MIR425 Gene

Genes around MIR425 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR425 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR425 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR425 Gene

ORGUL Member Location for MIR425 Gene

ORGUL Member Location for MIR425 gene

Proteins for MIR425 Gene

Post-translational modifications for MIR425 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR425 Gene

Domains & Families for MIR425 Gene

Gene Families for MIR425 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR425: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR425 Gene

Function for MIR425 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR425 Gene

Localization for MIR425 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR425 Gene

Pathways & Interactions for MIR425 Gene

SuperPathways for MIR425 Gene

No Data Available

Interacting Proteins for MIR425 Gene

Gene Ontology (GO) - Biological Process for MIR425 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR425 Gene

Drugs & Compounds for MIR425 Gene

No Compound Related Data Available

Transcripts for MIR425 Gene

fRNAdb Secondary structures for MIR425 Gene

  • FR402885

mRNA/cDNA for MIR425 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR425 Gene

No ASD Table

Relevant External Links for MIR425 Gene

GeneLoc Exon Structure for
MIR425
ECgene alternative splicing isoforms for
MIR425

Expression for MIR425 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR425 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR425 Gene:

MIR425
genes like me logo Genes that share expression patterns with MIR425: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR425 Gene

Orthologs for MIR425 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR425 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-425 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-425 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir425 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-425 35
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-425 35
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-425 35
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-425 35
  • 74 (a)
OneToOne
Species where no ortholog for MIR425 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR425 Gene

ENSEMBL:
Gene Tree for MIR425 (if available)
TreeFam:
Gene Tree for MIR425 (if available)

Paralogs for MIR425 Gene

No data available for Paralogs for MIR425 Gene

Variants for MIR425 Gene

Sequence variations from dbSNP and Humsavar for MIR425 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs121918136 Pathogenic 49,022,146(+) AGCCA(C/T)GGCCA intron-variant, upstream-variant-2KB, reference, missense
rs567032648 Likely pathogenic 49,022,175(+) GCTTG(C/G/T)ACCGA intron-variant, upstream-variant-2KB, reference, missense
rs573066357 Uncertain significance 49,021,904(+) TCCCC(C/T)GGGAC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs74601553 Uncertain significance 49,022,018(+) GGGCC(C/G)GTCGA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs75749590 Uncertain significance 49,022,019(+) GGCCG(C/G)TCGAG intron-variant, upstream-variant-2KB, utr-variant-5-prime

Relevant External Links for MIR425 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR425

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR425 Gene

Disorders for MIR425 Gene

Relevant External Links for MIR425

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR425

No disorders were found for MIR425 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR425 Gene

Publications for MIR425 Gene

  1. Clustering and conservation patterns of human microRNAs. (PMID: 15891114) Altuvia Y. … Margalit H. (Nucleic Acids Res. 2005) 1 3 64
  2. A pancreatic islet-specific microRNA regulates insulin secretion. (PMID: 15538371) Poy M.N. … Stoffel M. (Nature 2004) 1 3 64
  3. MicoRNA-425-5p is a potential prognostic biomarker for cervical cancer. (PMID: 27166306) Sun L. … Mu N. (Ann. Clin. Biochem. 2017) 3 64
  4. MicroRNA-425-5p regulates chemoresistance in colorectal cancer cells via regulation of Programmed Cell Death 10. (PMID: 26647742) Zhang Y. … Wang T. (J. Cell. Mol. Med. 2016) 3 64
  5. Identification of valid reference genes for microRNA expression studies in a hepatitis B virus replicating liver cell line. (PMID: 26801621) Jacobsen K.S. … Hogh B. (BMC Res Notes 2016) 3 64

Products for MIR425 Gene

Sources for MIR425 Gene

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