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Aliases for MIR425 Gene

Subcategory (RNA class) for MIR425 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR425 Gene

  • MicroRNA 425 2 3 5
  • Hsa-Mir-425 3
  • Mir-425 3
  • MIRN425 3

External Ids for MIR425 Gene

Previous HGNC Symbols for MIR425 Gene

  • MIRN425

Previous GeneCards Identifiers for MIR425 Gene

  • GC03M049049
  • GC03M049053
  • GC03M049057
  • GC03M049070
  • GC03M049079
  • GC03M049084
  • GC03M049089

Summaries for MIR425 Gene

Entrez Gene Summary for MIR425 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR425 Gene

MIR425 (MicroRNA 425) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR425 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR425

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR425 Gene

Genomics for MIR425 Gene

Regulatory Elements for MIR425 Gene

Enhancers for MIR425 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F049338 0.7 FANTOM5 ENCODE 10.5 -325.8 -325816 14.7 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 AMT QRICH1 BSN-AS1 IMPDH2 LOC105377080 DALRD3 RHOA C3orf84 PHF5EP WDR6
GH03F048769 1 Ensembl ENCODE 9.6 +249.9 249867 1.3 PRDM1 PRKAR2A PRKAR2A-AS1 NCKIPSD COL7A1 MIR711 PFKFB4 UCN2 MIR6890 QARS QRICH1
GH03F049016 0.2 ENCODE 0.8 0.0 -27 6.8 PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF207 WDR6 AMT BSN-AS1 LOC105377080 C3orf84 RPL17P16 NDUFB1P1 PHF5EP RN7SL664P NICN1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR425 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR425 Gene

Chromosome:
3
Start:
49,020,148 bp from pter
End:
49,020,234 bp from pter
Size:
87 bases
Orientation:
Minus strand

Genomic View for MIR425 Gene

Genes around MIR425 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR425 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR425 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR425 Gene

ORGUL Member Location for MIR425 Gene

ORGUL Member Location for MIR425 gene

Proteins for MIR425 Gene

Post-translational modifications for MIR425 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR425 Gene

Domains & Families for MIR425 Gene

Gene Families for MIR425 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR425: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR425 Gene

Function for MIR425 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR425 Gene

Localization for MIR425 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR425 Gene

Pathways & Interactions for MIR425 Gene

SuperPathways for MIR425 Gene

No Data Available

Interacting Proteins for MIR425 Gene

Gene Ontology (GO) - Biological Process for MIR425 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR425 Gene

Transcripts for MIR425 Gene

fRNAdb Secondary structures for MIR425 Gene

  • FR402885

mRNA/cDNA for MIR425 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR425 Gene

No ASD Table

Relevant External Links for MIR425 Gene

GeneLoc Exon Structure for
MIR425
ECgene alternative splicing isoforms for
MIR425

Expression for MIR425 Gene

mRNA expression in normal human tissues for MIR425 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR425 Gene:

MIR425
genes like me logo Genes that share expression patterns with MIR425: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR425 Gene

Orthologs for MIR425 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR425 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-425 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-425 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir425 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-425 35
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-425 35
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-425 35
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-425 35
  • 74 (a)
OneToOne
Species where no ortholog for MIR425 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR425 Gene

ENSEMBL:
Gene Tree for MIR425 (if available)
TreeFam:
Gene Tree for MIR425 (if available)

Paralogs for MIR425 Gene

No data available for Paralogs for MIR425 Gene

Variants for MIR425 Gene

Sequence variations from dbSNP and Humsavar for MIR425 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs121918136 Pathogenic 49,022,146(+) AGCCA(C/T)GGCCA intron-variant, upstream-variant-2KB, reference, missense
rs567032648 Likely pathogenic 49,022,175(+) GCTTG(C/G/T)ACCGA intron-variant, upstream-variant-2KB, reference, missense
rs113821860 -- 49,020,287(+) AACCC(G/T)CAGTC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs114259611 -- 49,021,546(+) ACCAC(A/C)TGGCC intron-variant, upstream-variant-2KB
rs11706445 -- 49,020,547(+) AGGAA(A/C)TGAGA intron-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime

Relevant External Links for MIR425 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR425

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR425 Gene

Disorders for MIR425 Gene

Relevant External Links for MIR425

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR425

No disorders were found for MIR425 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR425 Gene

Publications for MIR425 Gene

  1. Clustering and conservation patterns of human microRNAs. (PMID: 15891114) Altuvia Y. … Margalit H. (Nucleic Acids Res. 2005) 1 3 64
  2. A pancreatic islet-specific microRNA regulates insulin secretion. (PMID: 15538371) Poy M.N. … Stoffel M. (Nature 2004) 1 3 64
  3. Identification of valid reference genes for microRNA expression studies in a hepatitis B virus replicating liver cell line. (PMID: 26801621) Jacobsen K.S. … Hogh B. (BMC Res Notes 2016) 3 64
  4. CTNNA3 is a tumor suppressor in hepatocellular carcinomas and is inhibited by miR-425. (PMID: 26882563) He B. … Zhang H.Q. (Oncotarget 2016) 3 64
  5. miR-425 inhibits melanoma metastasis through repression of PI3K-Akt pathway by targeting IGF-1. (PMID: 26463631) Liu P. … Hu Z. (Biomed. Pharmacother. 2015) 3 64

Products for MIR425 Gene

Sources for MIR425 Gene

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