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Aliases for MIR425 Gene

Subcategory (RNA class) for MIR425 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR425 Gene

  • MicroRNA 425 2 3
  • Hsa-Mir-425 3
  • MIRN425 3

External Ids for MIR425 Gene

Previous Symbols for MIR425 Gene

  • MIRN425

Summaries for MIR425 Gene

Entrez Gene Summary for MIR425 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR425 Gene

MIR425 (MicroRNA 425) is an RNA Gene, and belongs to the miRNA class.

fRNAdb sequence ontologies for MIR425 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR425

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR425 Gene

Genomics for MIR425 Gene

Genomic Location for MIR425 Gene

Start:
49,020,148 bp from pter
End:
49,020,234 bp from pter
Size:
87 bases
Orientation:
Minus strand

Genomic View for MIR425 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR425 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR425 Gene

ORGUL Member Location for MIR425 Gene

ORGUL Member Location for MIR425 gene

No data available for Regulatory Elements for MIR425 Gene

Proteins for MIR425 Gene

Post-translational modifications for MIR425 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR425 Gene

Domains for MIR425 Gene

Gene Families for MIR425 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR425: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR425 Gene

Function for MIR425 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR425 Gene

Localization for MIR425 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR425 Gene

Pathways for MIR425 Gene

SuperPathways for MIR425 Gene

No Data Available

Interacting Proteins for MIR425 Gene

Gene Ontology (GO) - Biological Process for MIR425 Gene

None

No data available for Pathways by source for MIR425 Gene

Transcripts for MIR425 Gene

fRNAdb Secondary structures for MIR425 Gene

  • FR402885

mRNA/cDNA for MIR425 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR425 Gene

No ASD Table

Relevant External Links for MIR425 Gene

GeneLoc Exon Structure for
MIR425
ECgene alternative splicing isoforms for
MIR425

Expression for MIR425 Gene

mRNA expression in normal human tissues for MIR425 Gene

genes like me logo Genes that share expressions with MIR425: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIR425 Gene

Orthologs for MIR425 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR425 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-425 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-425 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-425 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir425 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-425 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-425 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-425 36
  • 74 (a)
OneToOne
Species with no ortholog for MIR425:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR425 Gene

ENSEMBL:
Gene Tree for MIR425 (if available)
TreeFam:
Gene Tree for MIR425 (if available)

Paralogs for MIR425 Gene

No data available for Paralogs for MIR425 Gene

Variants for MIR425 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR425 Gene

Variant ID Type Subtype PubMed ID
nsv876764 CNV Loss 21882294

Relevant External Links for MIR425 Gene

HapMap Linkage Disequilibrium report
MIR425

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MIR425 Gene

Disorders for MIR425 Gene

No disorders were found for MIR425 Gene.

No data available for UniProtKB/Swiss-Prot for MIR425 Gene

Publications for MIR425 Gene

  1. A pancreatic islet-specific microRNA regulates insulin secretion. (PMID: 15538371) Poy M.N. … Stoffel M. (Nature 2004) 3
  2. Clustering and conservation patterns of human microRNAs. (PMID: 15891114) Altuvia Y. … Margalit H. (Nucleic Acids Res. 2005) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  4. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  5. Patterns of known and novel small RNAs in human cervical cancer. (PMID: 17616659) Lui W.O. … Fire A. (Cancer Res. 2007) 3

Products for MIR425 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MIR425
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MIR425
    • Block miRNA regulation of MIR425 using miScript Target Protectors

    Sources for MIR425 Gene

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