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Aliases for MIR424 Gene

Subcategory (RNA class) for MIR424 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR424 Gene

  • MicroRNA 424 2 3 5
  • Hsa-Mir-424 3
  • MiRNA424 3
  • Mir-424 3
  • MIRN424 3
  • MIR322 3

External Ids for MIR424 Gene

Previous HGNC Symbols for MIR424 Gene

  • MIRN424

Previous GeneCards Identifiers for MIR424 Gene

  • GC0XM133521
  • GC0XM133523
  • GC0XM133681
  • GC0XM133686
  • GC0XM133696
  • GC0XM133713
  • GC0XM134549
  • GC0XM134556
  • GC0XM134566
  • GC0XM134571
  • GC0XM134576
  • GC0XM134581

Summaries for MIR424 Gene

Entrez Gene Summary for MIR424 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR424 Gene

MIR424 (MicroRNA 424) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR424 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR424 Gene

Genomics for MIR424 Gene

Regulatory Elements for MIR424 Gene

Enhancers for MIR424 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH134541 1.5 Ensembl ENCODE dbSUPER 0.7 -1.5 -1476 12 PKNOX1 ATF1 ARNT SIN3A GLI4 ZNF2 ZNF766 GLIS2 CBX5 ZNF143 ZNF75D MIR503HG MIR424 GC0XM134597 LINC00629
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR424 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR424 Gene

Chromosome:
X
Start:
134,546,614 bp from pter
End:
134,546,711 bp from pter
Size:
98 bases
Orientation:
Minus strand

Genomic View for MIR424 Gene

Genes around MIR424 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR424 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR424 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR424 Gene

Proteins for MIR424 Gene

Post-translational modifications for MIR424 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR424 Gene

Domains & Families for MIR424 Gene

Gene Families for MIR424 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR424: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR424 Gene

Function for MIR424 Gene

Gene Ontology (GO) - Molecular Function for MIR424 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 21885851
genes like me logo Genes that share ontologies with MIR424: view

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR424
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR424 Gene

Localization for MIR424 Gene

Gene Ontology (GO) - Cellular Components for MIR424 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 25203061
genes like me logo Genes that share ontologies with MIR424: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR424 Gene

Pathways & Interactions for MIR424 Gene

SuperPathways for MIR424 Gene

No Data Available

Interacting Proteins for MIR424 Gene

Gene Ontology (GO) - Biological Process for MIR424 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001937 negative regulation of endothelial cell proliferation IDA 21885851
GO:0035195 gene silencing by miRNA IDA 21885851
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway IDA 21885851
GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway IDA 21885851
GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IDA 21885851
genes like me logo Genes that share ontologies with MIR424: view

No data available for Pathways by source and SIGNOR curated interactions for MIR424 Gene

Drugs & Compounds for MIR424 Gene

No Compound Related Data Available

Transcripts for MIR424 Gene

mRNA/cDNA for MIR424 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR424
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR424 Gene

No ASD Table

Relevant External Links for MIR424 Gene

GeneLoc Exon Structure for
MIR424
ECgene alternative splicing isoforms for
MIR424

Expression for MIR424 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR424 Gene:

MIR424
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR424 Gene

Orthologs for MIR424 Gene

Evolution for MIR424 Gene

ENSEMBL:
Gene Tree for MIR424 (if available)
TreeFam:
Gene Tree for MIR424 (if available)

No data available for Orthologs for MIR424 Gene

Paralogs for MIR424 Gene

No data available for Paralogs for MIR424 Gene

Variants for MIR424 Gene

Sequence variations from dbSNP and Humsavar for MIR424 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000401062 -- 134,548,235(+) AAGTT(-/AA)AGTCA upstream-variant-2KB
rs1003289199 -- 134,547,514(+) CACAG(A/C)AACTT upstream-variant-2KB
rs1005614992 -- 134,547,140(+) AAAAA(C/T)AAAAA upstream-variant-2KB
rs1009051285 -- 134,546,570(+) GGCCT(A/C)GCGGG nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB
rs1010330507 -- 134,547,633(+) GCCCT(C/T)TTTTT upstream-variant-2KB

Relevant External Links for MIR424 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR424

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR424 Gene

Disorders for MIR424 Gene

Relevant External Links for MIR424

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR424

No disorders were found for MIR424 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR424 Gene

Publications for MIR424 Gene

  1. MiR-424 Promotes Non-Small Cell Lung Cancer Progression and Metastasis through Regulating the Tumor Suppressor Gene TNFAIP1. (PMID: 28535539) Zhang M … Li W (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017) 3 60
  2. miR424-5p functions as an anti-oncogene in cervical cancer cell growth by targeting KDM5B via the Notch signaling pathway. (PMID: 28082020) Zhou Y … Zhao XL (Life sciences 2017) 3 60
  3. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 60
  4. MicroRNA-424 impairs ubiquitination to activate STAT3 and promote prostate tumor progression. (PMID: 27820701) Dallavalle C … Carbone GM (The Journal of clinical investigation 2016) 3 60
  5. MicroRNAs-424 and 206 are potential prognostic markers in spinal onset amyotrophic lateral sclerosis. (PMID: 27538595) de Andrade HM … França MC (Journal of the neurological sciences 2016) 3 60

Products for MIR424 Gene

Sources for MIR424 Gene

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