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Aliases for MIR424 Gene

Subcategory (RNA class) for MIR424 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR424 Gene

  • MicroRNA 424 2 3 5
  • Hsa-Mir-424 3
  • MiRNA424 3
  • Mir-424 3
  • MIRN424 3
  • MIR322 3

External Ids for MIR424 Gene

Previous HGNC Symbols for MIR424 Gene

  • MIRN424

Previous GeneCards Identifiers for MIR424 Gene

  • GC0XM133521
  • GC0XM133523
  • GC0XM133681
  • GC0XM133686
  • GC0XM133696
  • GC0XM133713
  • GC0XM134549
  • GC0XM134556

Summaries for MIR424 Gene

Entrez Gene Summary for MIR424 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR424 Gene

MIR424 (MicroRNA 424) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRNAs involved in DDR.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR424 Gene

Genomics for MIR424 Gene

Regulatory Elements for MIR424 Gene

Promoters for MIR424 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIR424 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR424 Gene

Chromosome:
X
Start:
134,546,611 bp from pter
End:
134,546,721 bp from pter
Size:
111 bases
Orientation:
Minus strand

Genomic View for MIR424 Gene

Genes around MIR424 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR424 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR424 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR424 Gene

Proteins for MIR424 Gene

Post-translational modifications for MIR424 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR424 Gene

Domains & Families for MIR424 Gene

Gene Families for MIR424 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR424: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR424 Gene

Function for MIR424 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR424 Gene

Localization for MIR424 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR424 Gene

Pathways & Interactions for MIR424 Gene

SuperPathways for MIR424 Gene

Superpath Contained pathways
1 miRNAs involved in DDR
genes like me logo Genes that share pathways with MIR424: view

Pathways by source for MIR424 Gene

1 BioSystems pathway for MIR424 Gene

Interacting Proteins for MIR424 Gene

Gene Ontology (GO) - Biological Process for MIR424 Gene

None

No data available for SIGNOR curated interactions for MIR424 Gene

Drugs & Compounds for MIR424 Gene

No Compound Related Data Available

Transcripts for MIR424 Gene

mRNA/cDNA for MIR424 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR424 Gene

No ASD Table

Relevant External Links for MIR424 Gene

GeneLoc Exon Structure for
MIR424
ECgene alternative splicing isoforms for
MIR424

Expression for MIR424 Gene

No Expression Related Data Available

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR424 Gene

Orthologs for MIR424 Gene

Evolution for MIR424 Gene

ENSEMBL:
Gene Tree for MIR424 (if available)
TreeFam:
Gene Tree for MIR424 (if available)

No data available for Orthologs for MIR424 Gene

Paralogs for MIR424 Gene

No data available for Paralogs for MIR424 Gene

Variants for MIR424 Gene

Relevant External Links for MIR424 Gene

HapMap Linkage Disequilibrium report
MIR424

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR424 Gene

Disorders for MIR424 Gene

Relevant External Links for MIR424

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR424

No disorders were found for MIR424 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR424 Gene

Publications for MIR424 Gene

  1. Regulation of myofibroblast differentiation by miR-424 during epithelial-to-mesenchymal transition. (PMID: 25524739) Xiao X. … Liu L. (Arch. Biochem. Biophys. 2015) 3
  2. miRs-138 and -424 control palmitoylation-dependent CD95-mediated cell death by targeting acyl protein thioesterases 1 and 2 in CLL. (PMID: 25670628) Berg V. … Frenzel L.P. (Blood 2015) 3
  3. MicroRNA-424 may function as a tumor suppressor in endometrial carcinoma cells by targeting E2F7. (PMID: 25708247) Li Q. … Xiao Y.B. (Oncol. Rep. 2015) 3
  4. TWIST1-Induced miR-424 Reversibly Drives Mesenchymal Programming while Inhibiting Tumor Initiation. (PMID: 25716682) Drasin D.J. … Ford H.L. (Cancer Res. 2015) 3
  5. miR-424 levels in hair shaft are increased in psoriatic patients. (PMID: 24628460) Tsuru Y. … Ihn H. (J. Dermatol. 2014) 3

Products for MIR424 Gene

Sources for MIR424 Gene

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