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Aliases for MIR423 Gene

Subcategory (RNA class) for MIR423 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR423 Gene

  • MicroRNA 423 2 3 5
  • Hsa-Mir-423 3
  • Mir-423 3
  • MIRN423 3

External Ids for MIR423 Gene

ORGUL Members for MIR423 Gene

Previous HGNC Symbols for MIR423 Gene

  • MIRN423

Previous GeneCards Identifiers for MIR423 Gene

  • GC17P025471
  • GC17P028444

Summaries for MIR423 Gene

Entrez Gene Summary for MIR423 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR423 Gene

MIR423 (MicroRNA 423) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR423 include Transposition Of The Great Arteries. Among its related pathways are MicroRNAs in cancer.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR423 Gene

Genomics for MIR423 Gene

Regulatory Elements for MIR423 Gene


Promoters for MIR423 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000092957 121 2001 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 FOS ZNF263

Genomic Location for MIR423 Gene

Chromosome:
17
Start:
30,117,079 bp from pter
End:
30,117,172 bp from pter
Size:
94 bases
Orientation:
Plus strand

Genomic View for MIR423 Gene

Genes around MIR423 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR423 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR423 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR423 Gene

Proteins for MIR423 Gene

Post-translational modifications for MIR423 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR423 Gene

Domains & Families for MIR423 Gene

Gene Families for MIR423 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR423: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR423 Gene

Function for MIR423 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR423 Gene

Localization for MIR423 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR423 Gene

Pathways & Interactions for MIR423 Gene

SuperPathways for MIR423 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR423: view

Pathways by source for MIR423 Gene

1 KEGG pathway for MIR423 Gene

Interacting Proteins for MIR423 Gene

Gene Ontology (GO) - Biological Process for MIR423 Gene

None

No data available for SIGNOR curated interactions for MIR423 Gene

Transcripts for MIR423 Gene

mRNA/cDNA for MIR423 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR423 Gene

No ASD Table

Relevant External Links for MIR423 Gene

GeneLoc Exon Structure for
MIR423
ECgene alternative splicing isoforms for
MIR423

Expression for MIR423 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR423 Gene:

MIR423
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR423 Gene

Orthologs for MIR423 Gene

Evolution for MIR423 Gene

ENSEMBL:
Gene Tree for MIR423 (if available)
TreeFam:
Gene Tree for MIR423 (if available)

No data available for Orthologs for MIR423 Gene

Paralogs for MIR423 Gene

No data available for Paralogs for MIR423 Gene

Variants for MIR423 Gene

Sequence variations from dbSNP and Humsavar for MIR423 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000221662 -- 30,116,946(+) ATGCG(C/G)TGGAA intron-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime
rs1002382108 -- 30,116,979(+) GGTAG(A/G)GACGG intron-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime
rs1004736069 -- 30,116,711(+) ACCAT(A/G)GAAGT downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime
rs1004877979 -- 30,117,283(+) TCCCG(C/T)CCTTC intron-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime
rs1008153560 -- 30,116,220(+) GAACC(C/T)GGGAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR423 Gene

Variant ID Type Subtype PubMed ID
dgv5518n54 CNV loss 21841781

Relevant External Links for MIR423 Gene

Human Gene Mutation Database (HGMD)
MIR423
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR423

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR423 Gene

Disorders for MIR423 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR423 Gene - From: GeneCards

Disorder Aliases PubMed IDs
transposition of the great arteries
  • dextro-looped transposition of the great arteries
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR423

Genetic Association Database (GAD)
MIR423
Human Genome Epidemiology (HuGE) Navigator
MIR423
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR423
genes like me logo Genes that share disorders with MIR423: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR423 Gene

Publications for MIR423 Gene

  1. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PMID: 19851984) Clague J. … Wu X. (Mol. Carcinog. 2010) 3 46 64
  2. Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women. (PMID: 19950226) Kontorovich T. … Friedman E. (Int. J. Cancer 2010) 3 46 64
  3. Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma. (PMID: 20732906) Lin J. … Wu X. (Carcinogenesis 2010) 3 46 64
  4. Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. (PMID: 19138993) Ye Y. … Wu X. (Cancer Prev Res (Phila) 2008) 3 46 64
  5. miR-423-5p knockdown enhances the sensitivity of glioma stem cells to apigenin through the mitochondrial pathway. (PMID: 28381178) Wan Y. … Zhou S. (Tumour Biol. 2017) 3 64

Products for MIR423 Gene

Sources for MIR423 Gene

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