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Aliases for MIR423 Gene

Subcategory (RNA class) for MIR423 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR423 Gene

  • MicroRNA 423 2 3
  • NSRP1 4 5
  • Nuclear Speckle Splicing Regulatory Protein 1 5
  • Coiled-Coil Domain-Containing Protein 55 4
  • Nuclear Speckle-Related Protein 70 4
  • Hsa-Mir-423 3
  • Mir-423 3
  • MIRN423 3
  • CCDC55 4
  • NSRP70 4

External Ids for MIR423 Gene

Previous HGNC Symbols for MIR423 Gene

  • MIRN423

Previous GeneCards Identifiers for MIR423 Gene

  • GC17P025471
  • GC17P028444

Summaries for MIR423 Gene

Entrez Gene Summary for MIR423 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR423 Gene

MIR423 (MicroRNA 423) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR423 include Transposition Of The Great Arteries. Among its related pathways are MicroRNAs in cancer.

UniProtKB/Swiss-Prot for MIR423 Gene

  • RNA-binding protein that mediates pre-mRNA alternative splicing regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR423 Gene

Genomics for MIR423 Gene

Regulatory Elements for MIR423 Gene

Enhancers for MIR423 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F030089 0.3 FANTOM5 11.4 -25.9 -25896 0.4 CTCF ESRRA SAP130 ARID4B RAD21 DNMT3B YY1 POLR2A NR2F6 THAP11 MIR423 NSRP1 GC17M030070
GH17F030093 0.6 Ensembl ENCODE 11.4 -21.8 -21820 0.6 CTCF ZNF654 WRNIP1 TRIM22 REST ZNF2 RAD21 IKZF1 ZNF512 ZNF143 NSRP1 MIR423 GC17M030070
GH17F030091 1 ENCODE 11.4 -23.4 -23405 0.5 JUND RFX5 NSRP1 MIR423 GC17M030070
GH17F030263 0.9 Ensembl ENCODE 11.1 +148.8 148791 1.7 OVOL3 FEZF1 ZNF843 YY1 OSR2 ZNF664 ZNF121 ATF3 WT1 SP7 BLMH SLC6A4 RNU6-1267P MIR423 NSRP1 CPD TBC1D29 LRRC37BP1 CORO6 GC17M030249
GH17F030270 0.4 ENCODE 11 +156.3 156305 1.9 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 BLMH ENSG00000252112 TMIGD1 SLC6A4 MIR423 NSRP1 LRRC37BP1 RNU6-1267P GC17M030249
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR423 on UCSC Golden Path with GeneCards custom track

Promoters for MIR423 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001343788 1780 2600 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 FOS ZNF263

Genomic Location for MIR423 Gene

Chromosome:
17
Start:
30,115,521 bp from pter
End:
30,186,475 bp from pter
Size:
70,955 bases
Orientation:
Plus strand

Genomic View for MIR423 Gene

Genes around MIR423 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR423 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR423 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR423 Gene

Proteins for MIR423 Gene

  • Protein details for MIR423 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0G5-NSRP1_HUMAN
    Recommended name:
    Nuclear speckle splicing regulatory protein 1
    Protein Accession:
    Q9H0G5
    Secondary Accessions:
    • Q6FI71

    Protein attributes for MIR423 Gene

    Size:
    558 amino acids
    Molecular mass:
    66390 Da
    Quaternary structure:
    • Interacts (via C-terminus) with SRSF1. Interacts (via C-terminus) with SRSF2.
    • Interacts (via C-terminus) with SRSF1. Interacts (via C-terminus) with SRSF2.

neXtProt entry for MIR423 Gene

Post-translational modifications for MIR423 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MIR423 Gene

Domains & Families for MIR423 Gene

Gene Families for MIR423 Gene

Protein Domains for MIR423 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9H0G5

UniProtKB/Swiss-Prot:

NSRP1_HUMAN :
  • Belongs to the NSRP1 family.
Family:
  • Belongs to the NSRP1 family.
genes like me logo Genes that share domains with MIR423: view

No data available for Suggested Antigen Peptide Sequences for MIR423 Gene

Function for MIR423 Gene

Molecular function for MIR423 Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein that mediates pre-mRNA alternative splicing regulation.
UniProtKB/Swiss-Prot Induction:
Up-regulated in motile T-cells.

Gene Ontology (GO) - Molecular Function for MIR423 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0003729 mRNA binding IDA --
GO:0005515 protein binding IPI --
GO:0044822 poly(A) RNA binding IDA --
genes like me logo Genes that share ontologies with MIR423: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR423 Gene

Localization for MIR423 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR423 Gene

Nucleus. Nucleus speckle. Note=Colocalizes with splicing factors SRSF1 and SRSF2 in speckles.

Gene Ontology (GO) - Cellular Components for MIR423 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0016607 nuclear speck IEA --
GO:0030529 intracellular ribonucleoprotein complex IDA --
genes like me logo Genes that share ontologies with MIR423: view

No data available for Subcellular locations from COMPARTMENTS for MIR423 Gene

Pathways & Interactions for MIR423 Gene

SuperPathways for MIR423 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR423: view

Pathways by source for MIR423 Gene

1 KEGG pathway for MIR423 Gene

Gene Ontology (GO) - Biological Process for MIR423 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0006913 nucleocytoplasmic transport IDA --
GO:0008380 RNA splicing IEA --
GO:0032502 developmental process IMP --
genes like me logo Genes that share ontologies with MIR423: view

No data available for SIGNOR curated interactions for MIR423 Gene

Transcripts for MIR423 Gene

mRNA/cDNA for MIR423 Gene

(18) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR423 Gene

No ASD Table

Relevant External Links for MIR423 Gene

GeneLoc Exon Structure for
MIR423
ECgene alternative splicing isoforms for
MIR423

Expression for MIR423 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR423 Gene:

MIR423

mRNA Expression by UniProt/SwissProt for MIR423 Gene:

Q9H0G5-NSRP1_HUMAN
Tissue specificity: Expressed in dendritic cells, T-cells, B-cells and natural killer cells. Expressed in secondary lymphoid organs such as spleen and mesenteric, axillary and brachial lymph nodes.

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR423 Gene

Orthologs for MIR423 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR423 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC55 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NSRP1 35
  • 84 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NSRP1 35
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc55 35
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NSRP1 35
  • 62 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NSRP1 35
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves NSRP1 35
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NSRP1 35
  • 54 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nsrp1 35
  • 41 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG15747 35
  • 30 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ccdc-55 35
  • 28 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4847 35
  • 49 (a)
OneToOne
Species where no ortholog for MIR423 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR423 Gene

ENSEMBL:
Gene Tree for MIR423 (if available)
TreeFam:
Gene Tree for MIR423 (if available)

Paralogs for MIR423 Gene

Pseudogenes.org Pseudogenes for MIR423 Gene

genes like me logo Genes that share paralogs with MIR423: view

No data available for Paralogs for MIR423 Gene

Variants for MIR423 Gene

Sequence variations from dbSNP and Humsavar for MIR423 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs111240087 -- 30,115,146(+) TCACT(C/T)TAATG upstream-variant-2KB
rs112170621 -- 30,117,187(+) TCCCC(A/G/T)CTTGG intron-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime
rs140633248 -- 30,115,666(+) TAATC(A/C)CAGCA intron-variant, upstream-variant-2KB
rs143222423 -- 30,117,430(+) TTTTG(A/C)TGCGG intron-variant, downstream-variant-500B, upstream-variant-2KB
rs144290802 -- 30,115,881(+) TGCCA(C/T)TGCAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR423 Gene

Variant ID Type Subtype PubMed ID
dgv5518n54 CNV loss 21841781

Relevant External Links for MIR423 Gene

Human Gene Mutation Database (HGMD)
MIR423
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR423

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR423 Gene

Disorders for MIR423 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR423 Gene - From: GeneCards

Disorder Aliases PubMed IDs
transposition of the great arteries
  • transposition of the great arteries, dextro-looped 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR423

Genetic Association Database (GAD)
MIR423
Human Genome Epidemiology (HuGE) Navigator
MIR423
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR423
genes like me logo Genes that share disorders with MIR423: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR423 Gene

Publications for MIR423 Gene

  1. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PMID: 19851984) Clague J. … Wu X. (Mol. Carcinog. 2010) 3 46 64
  2. Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women. (PMID: 19950226) Kontorovich T. … Friedman E. (Int. J. Cancer 2010) 3 46 64
  3. Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma. (PMID: 20732906) Lin J. … Wu X. (Carcinogenesis 2010) 3 46 64
  4. Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. (PMID: 19138993) Ye Y. … Wu X. (Cancer Prev Res (Phila) 2008) 3 46 64
  5. Disease specific enrichment of circulating let-7 family microRNA in MuSK+ myasthenia gravis. (PMID: 26943954) Punga T. … Punga A.R. (J. Neuroimmunol. 2016) 3 64

Products for MIR423 Gene

Sources for MIR423 Gene

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