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Aliases for MIR423 Gene

Subcategory (RNA class) for MIR423 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR423 Gene

  • MicroRNA 423 2 3
  • Hsa-Mir-423 3
  • MIRN423 3

External Ids for MIR423 Gene

ORGUL Members for MIR423 Gene

Previous Symbols for MIR423 Gene

  • MIRN423

Summaries for MIR423 Gene

Entrez Gene Summary for MIR423 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR423 Gene

MIR423 (MicroRNA 423) is a RNA Gene, and belongs to miRNA RNA class. Diseases associated with MIR423 include esophageal cancer and transposition of the great arteries. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR423 Gene

Genomics for MIR423 Gene

Genomic Location for MIR423 Gene

Start:
30,117,079 bp from pter
End:
30,117,172 bp from pter
Size:
94 bases
Orientation:
Plus strand

Genomic View for MIR423 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR423 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR423 Gene

No data available for Regulatory Elements for MIR423 Gene

Proteins for MIR423 Gene

Post-translational modifications for MIR423 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR423 Gene

Domains for MIR423 Gene

Gene Families for MIR423 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs
genes like me logo Genes that share domains with MIR423: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for MIR423 Gene

Function for MIR423 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR423 Gene

Localization for MIR423 Gene

No data available for Gene Ontology (GO) - Cellular Components for MIR423 Gene

Pathways for MIR423 Gene

SuperPathways for MIR423 Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR423: view

Pathways by source for MIR423 Gene

1 KEGG pathway for MIR423 Gene

Interacting Proteins for MIR423 Gene

Gene Ontology (GO) - Biological Process for MIR423 Gene

None

Transcripts for MIR423 Gene

mRNA/cDNA for MIR423 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR423 Gene

No ASD Table

Relevant External Links for MIR423 Gene

GeneLoc Exon Structure for
MIR423
ECgene alternative splicing isoforms for
MIR423

Expression for MIR423 Gene

No Expression Related Data Available

Orthologs for MIR423 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR423 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-423 37
  • 76 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-423 37
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-423a 37
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir423 37
  • 76 (a)
OneToOne
Species with no ortholog for MIR423:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR423 Gene

ENSEMBL:
Gene Tree for MIR423 (if available)
TreeFam:
Gene Tree for MIR423 (if available)

Paralogs for MIR423 Gene

No data available for Paralogs for MIR423 Gene

Variants for MIR423 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR423 Gene

Variant ID Type Subtype PubMed ID
nsv908042 CNV Loss 21882294

Relevant External Links for MIR423 Gene

HapMap Linkage Disequilibrium report
MIR423

No data available for Sequence variations from dbSNP and Humsavar for MIR423 Gene

Disorders for MIR423 Gene

Relevant External Links for MIR423

Genetic Association Database (GAD)
MIR423
Human Genome Epidemiology (HuGE) Navigator
MIR423
genes like me logo Genes that share disorders with MIR423: view

No data available for UniProtKB/Swiss-Prot for MIR423 Gene

Publications for MIR423 Gene

  1. Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. (PMID: 19138993) Ye Y. … Wu X. (Cancer Prev Res (Phila) 2008) 3 49
  2. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PMID: 19851984) Clague J. … Wu X. (Mol. Carcinog. 2010) 3 49
  3. Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women. (PMID: 19950226) Kontorovich T. … Friedman E. (Int. J. Cancer 2010) 3 49
  4. Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma. (PMID: 20732906) Lin J. … Wu X. (Carcinogenesis 2010) 3 49
  5. MicroRNA-423 promotes cell growth and regulates G(1)/S transition by targeting p21Cip1/Waf1 in hepatocellular carcinoma. (PMID: 21890460) Lin J. … He X. (Carcinogenesis 2011) 3

Products for MIR423 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MIR423
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MIR423
    • Block miRNA regulation of MIR423 using miScript Target Protectors

    Sources for MIR423 Gene

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