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Aliases for MIR423 Gene

Subcategory (RNA class) for MIR423 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR423 Gene

  • MicroRNA 423 2 3 5
  • Hsa-Mir-423 3
  • Mir-423 3
  • MIRN423 3

External Ids for MIR423 Gene

ORGUL Members for MIR423 Gene

Previous HGNC Symbols for MIR423 Gene

  • MIRN423

Previous GeneCards Identifiers for MIR423 Gene

  • GC17P025471
  • GC17P028444

Summaries for MIR423 Gene

Entrez Gene Summary for MIR423 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR423 Gene

MIR423 (MicroRNA 423) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR423 include Vulvar Intraepithelial Neoplasia and Transposition Of The Great Arteries. Among its related pathways are MicroRNAs in cancer.

Additional gene information for MIR423 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR423 Gene

Genomics for MIR423 Gene

GeneHancer (GH) Regulatory Elements for MIR423 Gene

Promoters and enhancers for MIR423 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I030116 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.4 364 2.6 PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 POLR2B ENSG00000265394 ENSG00000266919 GC17P030118 PIR49703 MIR423 NSRP1 MIR3184 NUFIP2 CORO6 ENSG00000264456
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR423 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR423 Gene

Genomic Locations for MIR423 Gene
chr17:30,117,079-30,117,172
(GRCh38/hg38)
Size:
94 bases
Orientation:
Plus strand
chr17:28,444,097-28,444,190
(GRCh37/hg19)

Genomic View for MIR423 Gene

Genes around MIR423 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR423 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR423 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR423 Gene

Proteins for MIR423 Gene

Post-translational modifications for MIR423 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR423 Gene

Domains & Families for MIR423 Gene

Gene Families for MIR423 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR423: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR423 Gene

Function for MIR423 Gene

Gene Ontology (GO) - Molecular Function for MIR423 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20190813
genes like me logo Genes that share ontologies with MIR423: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR423 Gene

Localization for MIR423 Gene

Gene Ontology (GO) - Cellular Components for MIR423 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR423: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR423 Gene

Pathways & Interactions for MIR423 Gene

SuperPathways for MIR423 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR423: view

Pathways by source for MIR423 Gene

1 KEGG pathway for MIR423 Gene

Interacting Proteins for MIR423 Gene

Gene Ontology (GO) - Biological Process for MIR423 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 20190813
genes like me logo Genes that share ontologies with MIR423: view

No data available for SIGNOR curated interactions for MIR423 Gene

Drugs & Compounds for MIR423 Gene

No Compound Related Data Available

Transcripts for MIR423 Gene

mRNA/cDNA for MIR423 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR423 Gene

No ASD Table

Relevant External Links for MIR423 Gene

GeneLoc Exon Structure for
MIR423
ECgene alternative splicing isoforms for
MIR423

Expression for MIR423 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR423 Gene:

MIR423
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR423 Gene

Orthologs for MIR423 Gene

Evolution for MIR423 Gene

ENSEMBL:
Gene Tree for MIR423 (if available)
TreeFam:
Gene Tree for MIR423 (if available)

No data available for Orthologs for MIR423 Gene

Paralogs for MIR423 Gene

No data available for Paralogs for MIR423 Gene

Variants for MIR423 Gene

Sequence variations from dbSNP and Humsavar for MIR423 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000221662 -- 30,116,946(+) C/G upstream_transcript_variant
rs1002382108 -- 30,116,979(+) A/G upstream_transcript_variant
rs1004736069 -- 30,116,711(+) A/G upstream_transcript_variant
rs1004877979 -- 30,117,283(+) C/T downstream_transcript_variant
rs1008153560 -- 30,116,220(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR423 Gene

Variant ID Type Subtype PubMed ID
dgv5518n54 CNV loss 21841781

Additional Variant Information for MIR423 Gene

Human Gene Mutation Database (HGMD)
MIR423
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR423

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR423 Gene

Disorders for MIR423 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR423 Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
vulvar intraepithelial neoplasia
  • vulvar intraepithelial tumor
transposition of the great arteries
  • transposition of the great arteries, dextro-looped 1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR423

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR423: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR423 Gene

Publications for MIR423 Gene

  1. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PMID: 19851984) Clague J … Wu X (Molecular carcinogenesis 2010) 3 44 58
  2. Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women. (PMID: 19950226) Kontorovich T … Friedman E (International journal of cancer 2010) 3 44 58
  3. Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma. (PMID: 20732906) Lin J … Wu X (Carcinogenesis 2010) 3 44 58
  4. Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. (PMID: 19138993) Ye Y … Wu X (Cancer prevention research (Philadelphia, Pa.) 2008) 3 44 58
  5. Targeting miR-423-5p Reverses Exercise Training-Induced HCN4 Channel Remodeling and Sinus Bradycardia. (PMID: 28821541) D'Souza A … Boyett MR (Circulation research 2017) 3 58

Products for MIR423 Gene

Sources for MIR423 Gene

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