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Aliases for MIR423 Gene

Subcategory (RNA class) for MIR423 Gene


Quality Score for this RNA gene is


Aliases for MIR423 Gene

  • MicroRNA 423 2 3 5
  • Hsa-Mir-423 3
  • Mir-423 3
  • MIRN423 3

External Ids for MIR423 Gene

ORGUL Members for MIR423 Gene

Previous HGNC Symbols for MIR423 Gene

  • MIRN423

Previous GeneCards Identifiers for MIR423 Gene

  • GC17P025471
  • GC17P028444

Summaries for MIR423 Gene

Entrez Gene Summary for MIR423 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR423 Gene

MIR423 (MicroRNA 423) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR423 include Transposition Of The Great Arteries. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR423 Gene

Genomics for MIR423 Gene

Regulatory Elements for MIR423 Gene

Promoters for MIR423 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIR423 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR423 Gene

30,117,079 bp from pter
30,117,172 bp from pter
94 bases
Plus strand

Genomic View for MIR423 Gene

Genes around MIR423 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR423 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR423 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR423 Gene

Proteins for MIR423 Gene

Post-translational modifications for MIR423 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR423 Gene

Domains & Families for MIR423 Gene

Gene Families for MIR423 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR423: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR423 Gene

Function for MIR423 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR423 Gene

Localization for MIR423 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR423 Gene

Pathways & Interactions for MIR423 Gene

SuperPathways for MIR423 Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR423: view

Pathways by source for MIR423 Gene

1 KEGG pathway for MIR423 Gene

Interacting Proteins for MIR423 Gene

Gene Ontology (GO) - Biological Process for MIR423 Gene


No data available for SIGNOR curated interactions for MIR423 Gene

Drugs & Compounds for MIR423 Gene

No Compound Related Data Available

Transcripts for MIR423 Gene

mRNA/cDNA for MIR423 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR423 Gene

No ASD Table

Relevant External Links for MIR423 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR423 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR423 Gene

Orthologs for MIR423 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR423 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-423 36
  • 76 (a)
(Canis familiaris)
Mammalia cfa-mir-423a 36
  • 76 (a)
(Mus musculus)
Mammalia Mir423 36
  • 76 (a)
(Pan troglodytes)
Mammalia ptr-mir-423 36
  • 76 (a)
Species with no ortholog for MIR423:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR423 Gene

Gene Tree for MIR423 (if available)
Gene Tree for MIR423 (if available)

Paralogs for MIR423 Gene

No data available for Paralogs for MIR423 Gene

Variants for MIR423 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR423 Gene

Variant ID Type Subtype PubMed ID
nsv908042 CNV Loss 21882294

Relevant External Links for MIR423 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR423 Gene

Disorders for MIR423 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR423 Gene - From: GeneCards

Disorder Aliases PubMed IDs
transposition of the great arteries
  • transposition of the great arteries, dextro-looped 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR423

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MIR423: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR423 Gene

Publications for MIR423 Gene

  1. Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women. (PMID: 19950226) Kontorovich T. … Friedman E. (Int. J. Cancer 2010) 3 48 67
  2. Genetic analysis and preliminary function study of miR-423 in breast cancer. (PMID: 25663458) Zhao H. … Zhu Z. (Tumour Biol. 2015) 3
  3. MicroRNA-423-5p targets O-GlcNAc transferase to induce apoptosis in cardiomyocytes. (PMID: 25776937) Luo P. … Li G. (Mol Med Rep 2015) 3
  4. The significance of detection of serum miR-423-5p and miR-484 for diagnosis of colorectal cancer. (PMID: 25807655) Lu X. … Lu J. (Clin. Lab. 2015) 3
  5. The polymorphism of rs6505162 in the MIR423 coding region and recurrent pregnancy loss. (PMID: 25926693) Su X. … Xia H.F. (Reproduction 2015) 3

Products for MIR423 Gene

Sources for MIR423 Gene