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Aliases for MIR422A Gene

Subcategory (RNA class) for MIR422A Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR422A Gene

  • MicroRNA 422a 2 3 5
  • Hsa-Mir-422a 3
  • MiR-422a 3
  • MIRN422A 3

External Ids for MIR422A Gene

Previous HGNC Symbols for MIR422A Gene

  • MIRN422A

Previous GeneCards Identifiers for MIR422A Gene

  • GC15M061952
  • GC15M064163

Summaries for MIR422A Gene

Entrez Gene Summary for MIR422A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR422A Gene

MIR422A (MicroRNA 422a) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR422A Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR422A

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR422A Gene

Genomics for MIR422A Gene

Regulatory Elements for MIR422A Gene

Enhancers for MIR422A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G063891 2 FANTOM5 Ensembl ENCODE dbSUPER 11.5 -23.5 -23486 6.8 HDGF PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 SIN3A FEZF1 ZNF2 ZNF766 DAPK2 HERC1 TRIP4 MIR422A ENSG00000259498 USP3-AS1 RPS27L USP3 ENSG00000275785 LOC101928988
GH15G063841 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.9 +28.3 28315 3.3 HDGF ATF1 ARNT ZNF766 ELK1 GATA2 SMARCB1 ZNF592 MEF2D CREB3 HERC1 MIR422A DAPK2 USP3-AS1 USP3 GC15M063862
GH15G063984 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.6 -115.7 -115662 3.7 HDAC1 PKNOX1 ZSCAN4 ZBTB40 RARA ZNF121 GATA2 RELB ETV6 IKZF2 DAPK2 HERC1 MIR422A USP3 TRIP4 LOC101928988
GH15G064008 1.4 Ensembl ENCODE dbSUPER 11.4 -139.4 -139387 3.2 HDGF PKNOX1 ZNF133 SIN3A GLIS2 ZNF143 ZNF207 FOS TBX21 GLIS1 DAPK2 MIR422A HERC1 LOC101928988
GH15G064003 1.4 Ensembl ENCODE dbSUPER 11.4 -133.8 -133843 1.8 SIN3A ZNF48 FOS KLF13 DEK SMARCB1 ZNF592 MBD2 SMARCA4 STAT3 HERC1 DAPK2 ZNF609 MIR422A LOC101928988
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR422A on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR422A Gene

Chromosome:
15
Start:
63,870,930 bp from pter
End:
63,871,019 bp from pter
Size:
90 bases
Orientation:
Minus strand

Genomic View for MIR422A Gene

Genes around MIR422A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR422A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR422A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR422A Gene

ORGUL Member Location for MIR422A Gene

ORGUL Member Location for MIR422A gene

Proteins for MIR422A Gene

Post-translational modifications for MIR422A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR422A Gene

Domains & Families for MIR422A Gene

Gene Families for MIR422A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR422A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR422A Gene

Function for MIR422A Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR422A Gene

Localization for MIR422A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR422A Gene

Pathways & Interactions for MIR422A Gene

SuperPathways for MIR422A Gene

No Data Available

Interacting Proteins for MIR422A Gene

Gene Ontology (GO) - Biological Process for MIR422A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR422A Gene

Drugs & Compounds for MIR422A Gene

No Compound Related Data Available

Transcripts for MIR422A Gene

fRNAdb Secondary structures for MIR422A Gene

  • FR118799

mRNA/cDNA for MIR422A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR422A Gene

No ASD Table

Relevant External Links for MIR422A Gene

GeneLoc Exon Structure for
MIR422A
ECgene alternative splicing isoforms for
MIR422A

Expression for MIR422A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR422A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR422A Gene:

MIR422A
genes like me logo Genes that share expression patterns with MIR422A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR422A Gene

Orthologs for MIR422A Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR422A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-422a 35
  • 100 (a)
OneToOne
Species where no ortholog for MIR422A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR422A Gene

ENSEMBL:
Gene Tree for MIR422A (if available)
TreeFam:
Gene Tree for MIR422A (if available)

Paralogs for MIR422A Gene

No data available for Paralogs for MIR422A Gene

Variants for MIR422A Gene

Sequence variations from dbSNP and Humsavar for MIR422A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1002184065 -- 63,871,606(+) AGACC(C/T)TCTGG upstream-variant-2KB
rs1002213842 -- 63,871,789(+) GCAGG(C/G)AGATC upstream-variant-2KB
rs1003222924 -- 63,870,584(+) CCCTC(C/T)GAAGC downstream-variant-500B
rs1004382824 -- 63,872,794(+) GCCTA(G/T)GGGGA upstream-variant-2KB
rs1004647315 -- 63,872,187(+) CTCCT(A/G/T)TGTGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR422A Gene

Variant ID Type Subtype PubMed ID
esv3636720 CNV loss 21293372
esv3636721 CNV gain 21293372

Relevant External Links for MIR422A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR422A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR422A Gene

Disorders for MIR422A Gene

Relevant External Links for MIR422A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR422A

No disorders were found for MIR422A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR422A Gene

Publications for MIR422A Gene

  1. Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells. (PMID: 15325244) Kasashima K. … Kozu T. (Biochem. Biophys. Res. Commun. 2004) 1 3 64
  2. miR-422a Inhibits Glioma Proliferation and Invasion by Targeting IGF1 and IGF1R. (PMID: 28277190) Wang H. … Lin Z. (Oncol. Res. 2017) 3 64
  3. Overexpression of miR-422a inhibits cell proliferation and invasion, and enhances chemosensitivity in osteosarcoma cells. (PMID: 27779704) Liu M. … Wang Y. (Oncol. Rep. 2016) 3 64
  4. miR-422a is an independent prognostic factor and functions as a potential tumor suppressor in colorectal cancer. (PMID: 27350737) Zheng G.X. … Wang C.X. (World J. Gastroenterol. 2016) 3 64
  5. Screening and preliminary validation of miRNAs with the regulation of hTERT in colorectal cancer. (PMID: 25845814) Qin Y.Z. … Ge L.Y. (Oncol. Rep. 2015) 3 64

Products for MIR422A Gene

Sources for MIR422A Gene

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