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Aliases for MIR421 Gene

Subcategory (RNA class) for MIR421 Gene


Quality Score for this RNA gene is


Aliases for MIR421 Gene

  • MicroRNA 421 2 3 5
  • Hsa-Mir-421 3
  • MIRN421 3

External Ids for MIR421 Gene

Previous HGNC Symbols for MIR421 Gene

  • MIRN421

Previous GeneCards Identifiers for MIR421 Gene

  • GC0XM073358
  • GC0XM073438

Summaries for MIR421 Gene

Entrez Gene Summary for MIR421 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR421 Gene

MIR421 (MicroRNA 421) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRNAs involved in DNA damage response and DNA Damage Response.

Additional gene information for MIR421 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR421 Gene

Genomics for MIR421 Gene

GeneHancer (GH) Regulatory Elements for MIR421 Gene

Promoters and enhancers for MIR421 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI074240 Enhancer 1 Ensembl ENCODE 13.2 -24.0 -23965 3 ELF3 FOXA2 THRB RARA CREM MIXL1 RXRA PPARG NFIL3 ETV4 GC0XP074243 RN7SL648P MIR374B MIR421 FTX ZCCHC13 MIR374A MIR545 JPX GC0XP074233
GH0XI074248 Enhancer 1 Ensembl ENCODE 13.2 -32.1 -32141 5 HDAC1 ELF3 FOXA2 FEZF1 ZBTB40 TCF12 ZNF121 ZSCAN5C FOS ZEB2 GC0XP074249 MIR374B MIR421 MIR374A MIR545 FTX JPX ENSG00000278421
GH0XI074246 Enhancer 0.6 ENCODE 13.2 -28.8 -28757 1.2 JUN CEBPB CEBPG EP300 FOSL1 JUND ATF4 FOS FOSL2 MIR374B MIR421 GC0XP074243 GC0XP074249 FTX
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR421 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR421 Gene

Genomic Locations for MIR421 Gene
85 bases
Minus strand

Genomic View for MIR421 Gene

Genes around MIR421 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR421 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR421 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR421 Gene

Proteins for MIR421 Gene

Post-translational modifications for MIR421 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR421 Gene

Domains & Families for MIR421 Gene

Gene Families for MIR421 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR421: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR421 Gene

Function for MIR421 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR421 Gene

Localization for MIR421 Gene

Gene Ontology (GO) - Cellular Components for MIR421 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR421: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR421 Gene

Pathways & Interactions for MIR421 Gene

genes like me logo Genes that share pathways with MIR421: view

Pathways by source for MIR421 Gene

Interacting Proteins for MIR421 Gene

Gene Ontology (GO) - Biological Process for MIR421 Gene


No data available for SIGNOR curated interactions for MIR421 Gene

Drugs & Compounds for MIR421 Gene

No Compound Related Data Available

Transcripts for MIR421 Gene

mRNA/cDNA for MIR421 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR421 Gene

No ASD Table

Relevant External Links for MIR421 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR421 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR421 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR421 Gene:

genes like me logo Genes that share expression patterns with MIR421: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR421 Gene

Orthologs for MIR421 Gene

Evolution for MIR421 Gene

Gene Tree for MIR421 (if available)
Gene Tree for MIR421 (if available)

No data available for Orthologs for MIR421 Gene

Paralogs for MIR421 Gene

No data available for Paralogs for MIR421 Gene

Variants for MIR421 Gene

Sequence variations from dbSNP and Humsavar for MIR421 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000002777 -- 74,219,524(-) C/T upstream_transcript_variant
rs1000033517 -- 74,218,756(-) A/G upstream_transcript_variant
rs1004138518 -- 74,218,503(-) G/A upstream_transcript_variant
rs1008055857 -- 74,219,346(-) G/T upstream_transcript_variant
rs1013069137 -- 74,218,345(-) T/C downstream_transcript_variant

Additional Variant Information for MIR421 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR421 Gene

Disorders for MIR421 Gene

Additional Disease Information for MIR421

No disorders were found for MIR421 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR421 Gene

Publications for MIR421 Gene

  1. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 58
  2. microRNA 421 induces apoptosis of c-33a cervical cancer cells via down-regulation of Bcl-xL. (PMID: 27886335) Lai XJ … Hu LD (Genetics and molecular research : GMR 2016) 3 58
  3. MicroRNA-421 inhibits breast cancer metastasis by targeting metastasis associated 1. (PMID: 27583980) Pan Y … Yang W (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016) 3 58
  4. MicroRNA-421 Gene Polymorphism in Gastric Carcinoma. (PMID: 27133200) Jin X … Yu N (Medical science monitor : international medical journal of experimental and clinical research 2016) 3 58
  5. MicroRNA-421 regulated by HIF-1α promotes metastasis, inhibits apoptosis, and induces cisplatin resistance by targeting E-cadherin and caspase-3 in gastric cancer. (PMID: 27016414) Ge X … Li J (Oncotarget 2016) 3 58

Products for MIR421 Gene

Sources for MIR421 Gene

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