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Aliases for MIR421 Gene

Subcategory (RNA class) for MIR421 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR421 Gene

  • MicroRNA 421 2 3 5
  • Hsa-Mir-421 3
  • MIRN421 3

External Ids for MIR421 Gene

Previous HGNC Symbols for MIR421 Gene

  • MIRN421

Previous GeneCards Identifiers for MIR421 Gene

  • GC0XM073358
  • GC0XM073438

Summaries for MIR421 Gene

Entrez Gene Summary for MIR421 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR421 Gene

MIR421 (MicroRNA 421) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are DNA damage response and miRNAs involved in DDR.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR421 Gene

Genomics for MIR421 Gene

Regulatory Elements for MIR421 Gene

Enhancers for MIR421 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF074246 1.1 ENCODE 13.2 -28.8 -28758 1.2 JUND JUN CEBPB EP300 MIR374B MIR421 GC0XP074243 GC0XP074249
GH0XF074240 0.9 Ensembl ENCODE 13.2 -24.0 -23966 3.0 ELF3 THRB RARA CREM MIXL1 ZNF263 PPARG CEBPA ETV4 SOX13 MIR374B MIR421 FTX ZCCHC13 MIR374A MIR545 JPX ENSG00000271430 RN7SL648P
GH0XF074248 1.2 Ensembl ENCODE 13.2 -32.2 -32203 5.1 ELF3 FEZF1 ZBTB40 ZNF121 ZEB2 ZNF843 SMARCA4 CEBPA GLIS1 KDM1A MIR374B MIR421 MIR374A MIR545 FTX JPX ENSG00000271430 GC0XP074249 ENSG00000278421
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR421 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR421 Gene

Chromosome:
X
Start:
74,218,377 bp from pter
End:
74,218,461 bp from pter
Size:
85 bases
Orientation:
Minus strand

Genomic View for MIR421 Gene

Genes around MIR421 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR421 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR421 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR421 Gene

Proteins for MIR421 Gene

Post-translational modifications for MIR421 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR421 Gene

Domains & Families for MIR421 Gene

Gene Families for MIR421 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR421: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR421 Gene

Function for MIR421 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR421 Gene

Localization for MIR421 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR421 Gene

Pathways & Interactions for MIR421 Gene

genes like me logo Genes that share pathways with MIR421: view

Pathways by source for MIR421 Gene

2 BioSystems pathways for MIR421 Gene

Interacting Proteins for MIR421 Gene

Gene Ontology (GO) - Biological Process for MIR421 Gene

None

No data available for SIGNOR curated interactions for MIR421 Gene

Transcripts for MIR421 Gene

mRNA/cDNA for MIR421 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR421 Gene

No ASD Table

Relevant External Links for MIR421 Gene

GeneLoc Exon Structure for
MIR421
ECgene alternative splicing isoforms for
MIR421

Expression for MIR421 Gene

mRNA expression in normal human tissues for MIR421 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR421 Gene:

MIR421
genes like me logo Genes that share expression patterns with MIR421: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR421 Gene

Orthologs for MIR421 Gene

Evolution for MIR421 Gene

ENSEMBL:
Gene Tree for MIR421 (if available)
TreeFam:
Gene Tree for MIR421 (if available)

No data available for Orthologs for MIR421 Gene

Paralogs for MIR421 Gene

No data available for Paralogs for MIR421 Gene

Variants for MIR421 Gene

Sequence variations from dbSNP and Humsavar for MIR421 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs12841109 -- 74,220,410(+) attta(A/G)agagg intron-variant, upstream-variant-2KB
rs12842361 -- 74,220,420(+) gtttg(G/T)gttaa intron-variant, upstream-variant-2KB
rs1341326 -- 74,219,632(-) GGGAA(A/G)TTTTC intron-variant, upstream-variant-2KB
rs144570538 -- 74,218,218(+) CTCCA(C/T)TTGAT intron-variant, downstream-variant-500B, upstream-variant-2KB
rs145641369 -- 74,218,848(+) AGTTT(A/C)AGTCA intron-variant, downstream-variant-500B, upstream-variant-2KB

Relevant External Links for MIR421 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR421

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR421 Gene

Disorders for MIR421 Gene

Relevant External Links for MIR421

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR421

No disorders were found for MIR421 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR421 Gene

Publications for MIR421 Gene

  1. MicroRNA-421 is a new potential diagnosis biomarker with higher sensitivity and specificity than carcinoembryonic antigen and cancer antigen 125 in gastric cancer. (PMID: 25510566) Wu J. … Wang J. (Biomarkers 2015) 3 64
  2. Level of circulated microRNA-421 in gastric carcinoma and related mechanisms. (PMID: 26823741) Zhao G. … Zhao J. (Int J Clin Exp Pathol 2015) 3 64
  3. Correlation between microRNA-421 expression level and prognosis of gastric cancer. (PMID: 26823855) Liu H. … Feng Y. (Int J Clin Exp Pathol 2015) 3 64
  4. MiR-421 regulates apoptosis of BGC-823 gastric cancer cells by targeting caspase-3. (PMID: 25041019) Wu J.H. … Wang J.J. (Asian Pac. J. Cancer Prev. 2014) 3 64
  5. Angiotensin-converting enzyme 2 is subject to post-transcriptional regulation by miR-421. (PMID: 24564768) Lambert D.W. … Turner A.J. (Clin. Sci. 2014) 3 64

Products for MIR421 Gene

Sources for MIR421 Gene

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