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Aliases for MIR421 Gene

Subcategory (RNA class) for MIR421 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR421 Gene

  • MicroRNA 421 2 3
  • Hsa-Mir-421 3
  • MIRN421 3

External Ids for MIR421 Gene

Previous HGNC Symbols for MIR421 Gene

  • MIRN421

Previous GeneCards Identifiers for MIR421 Gene

  • GC0XM073358
  • GC0XM073438

Summaries for MIR421 Gene

Entrez Gene Summary for MIR421 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR421 Gene

MIR421 (MicroRNA 421) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRNAs involved in DDR.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR421 Gene

Genomics for MIR421 Gene

Genomic Location for MIR421 Gene

Start:
74,218,373 bp from pter
End:
74,218,484 bp from pter
Size:
112 bases
Orientation:
Minus strand

Genomic View for MIR421 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR421 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR421 Gene

No data available for Regulatory Elements for MIR421 Gene

Proteins for MIR421 Gene

Post-translational modifications for MIR421 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR421 Gene

Domains for MIR421 Gene

Gene Families for MIR421 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR421: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR421 Gene

Function for MIR421 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR421 Gene

Localization for MIR421 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR421 Gene

Pathways for MIR421 Gene

SuperPathways for MIR421 Gene

Superpath Contained pathways
1 miRNAs involved in DDR
genes like me logo Genes that share pathways with MIR421: view

Pathways by source for MIR421 Gene

1 BioSystems pathway for MIR421 Gene

Interacting Proteins for MIR421 Gene

Gene Ontology (GO) - Biological Process for MIR421 Gene

None

Transcripts for MIR421 Gene

mRNA/cDNA for MIR421 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR421 Gene

No ASD Table

Relevant External Links for MIR421 Gene

GeneLoc Exon Structure for
MIR421
ECgene alternative splicing isoforms for
MIR421

Expression for MIR421 Gene

mRNA expression in normal human tissues for MIR421 Gene

genes like me logo Genes that share expressions with MIR421: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIR421 Gene

Orthologs for MIR421 Gene

Evolution for MIR421 Gene

ENSEMBL:
Gene Tree for MIR421 (if available)
TreeFam:
Gene Tree for MIR421 (if available)

No data available for Orthologs for MIR421 Gene

Paralogs for MIR421 Gene

No data available for Paralogs for MIR421 Gene

Variants for MIR421 Gene

Relevant External Links for MIR421 Gene

HapMap Linkage Disequilibrium report
MIR421

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for MIR421 Gene

Disorders for MIR421 Gene

No disorders were found for MIR421 Gene.

No data available for UniProtKB/Swiss-Prot for MIR421 Gene

Publications for MIR421 Gene

  1. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  2. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3
  3. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  4. Increased expression of miR-421 in human gastric carcinoma and its clinical association. (PMID: 19802518) Jiang Z. … Zhang Y. (J. Gastroenterol. 2010) 3
  5. ATM is down-regulated by N-Myc-regulated microRNA-421. (PMID: 20080624) Hu H. … Gatti R.A. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3

Products for MIR421 Gene

Sources for MIR421 Gene

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